Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis

Journal of Biological Chemistry

Volumn 287, Issue 28, 2012, Pages 23318-23331

  Shioda, Norifumi ^a   Ishikawa, Kiyoshi ^a   Tagashira, Hideaki ^a   Ishizuka, Toru ^a   Yawo, Hiromu ^a   Fukunaga, Kohji ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURVIVAL; CONTACT SURFACE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM CHAPERONE; ER STRESS; FRAMESHIFT; ISOFORMS; MITOCHONDRIAL ENERGY; OVER-EXPRESSION; PERINUCLEAR REGION; R-FUNCTIONS; RIBONUCLEOTIDES; SPLICE VARIANTS;

CALCIUM; CELL MEMBRANES; SUGARS;

CELL DEATH;

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CHAPERONE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; RIBONUCLEOTIDE; SIGMA1 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CALCIUM TRANSPORT; CELL NUCLEUS; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EXON; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SPLICING DEFECT; TISSUE DISTRIBUTION;

ADENOSINE TRIPHOSPHATE; ALTERNATIVE SPLICING; ANIMALS; APOPTOSIS; BRAIN; CALCIUM; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; IMMUNOBLOTTING; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; LUMINESCENT PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTORS, SIGMA; RNA INTERFERENCE;

EID: 84863612666     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.349142     Document Type: Article

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