COMT Val158Met genotype influences neurodegeneration within dopamineinnervated brain structures

Neurology

Volumn 78, Issue 21, 2012, Pages 1663-1669

  Gennatas, E D ^a   Cholfin, J A ^a   Zhou, J ^a   Crawford, R K ^a   Sasaki, D A ^a   Karydas, A ^a   Boxer, A L ^a   Bonasera, S J ^b   Rankin, K P ^a   Gorno Tempini, M L ^a   Rosen, H J ^a   Kramer, J H ^a   Weiner, M ^c   Miller, B L ^a   Seeley, W W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; METHIONINE; VALINE;

ADRENERGIC NERVE; ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; COGNITIVE DEFECT; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; FEMALE; FRONTAL VARIANT FRONTOTEMPORAL DEMENTIA; GENE DOSAGE; GENE FREQUENCY; GENE MUTATION; GENOTYPE; GRAY MATTER; HUMAN; HYPOTHESIS; INSULA; MAJOR CLINICAL STUDY; MALE; NERVE DEGENERATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; REGRESSION ANALYSIS; SEMANTIC DEMENTIA; SINGLE NUCLEOTIDE POLYMORPHISM; SYNAPSE; VENTRAL TEGMENTUM; VENTROMEDIAL PREFRONTAL CORTEX; VOXEL BASED MORPHOMETRY; ALLELE; BRAIN CORTEX; COMPARATIVE STUDY; DEMENTIA; FRONTOTEMPORAL DEMENTIA; GENETICS; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY;

AGED; ALLELES; ALZHEIMER DISEASE; CATECHOL O-METHYLTRANSFERASE; CEREBRAL CORTEX; DEMENTIA; DOPAMINE; FEMALE; FRONTOTEMPORAL DEMENTIA; FRONTOTEMPORAL LOBAR DEGENERATION; GENOTYPE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; METHIONINE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; VALINE;

EID: 84863607438     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3182574fa1     Document Type: Article

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