Younger genes are less likely to be essential than older genes, and duplicates are less likely to be essential than singletons of the same age

Molecular Biology and Evolution

Volumn 29, Issue 7, 2012, Pages 1703-1706

  Chen, Wei Hua ^a   Trachana, Kalliopi ^a   Lercher, Martin J ^b   Bork, Peer ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

gene essentiality; linking genotype to phenotype; mouse; phyletic age; yeast

Indexed keywords

ARTICLE; GENE; GENE DUPLICATION; GENETIC LINKAGE; GENOTYPE; NONHUMAN; PHENOTYPE; YEAST;

ANIMALS; DROSOPHILA MELANOGASTER; EVOLUTION, MOLECULAR; GENES, DUPLICATE; GENES, ESSENTIAL; MICE; SACCHAROMYCES CEREVISIAE;

EID: 84863602540     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/mss014     Document Type: Article

References (17)

1. Blake JA, Bult CJ, Kadin JA, Richardson JE, Eppig JT. Mouse Genome Database G. 2011. The Mouse Genome Database (MGD):premier model organism resource for mammalian genomics and genetics. Nucleic Acids Res. 39:D842-D848.
2. Chen S, Zhang YE, Long M. 2010. New genes in Drosophila quickly become essential. Science 330:1682-1685.
3. Chen WH, Minguez P, Lercher MJ, Bork P. 2012. OGEE: An online gene essentiality database. Nucleic Acids Res. 40:D901-D906.
4. Cherry JM, Ball C, Weng S, et al. (11 co-authors). 1997. Genetic and physical maps of Saccharomyces cerevisiae. Nature 387:67-73. (Pubitemid 27334668)
5. Enright AJ, Van Dongen S, Ouzounis CA. 2002. An efficient algorithm for large-scale detection of protein families. Nucleic Acids Res. 30:1575-1584. (Pubitemid 34679732)
6. Gu Z, Steinmetz LM, Gu X, Scharfe C, Davis RW, Li WH. 2003. Role of duplicate genes in genetic robustness against null mutations. Nature 421:63-66. (Pubitemid 36077084)
7. Hao L, Ge X, Wan H, Hu S, Lercher M, Yu J, Chen W-H. 2010. Human functional genetic studies are biased against the medically most relevant primate-specific genes. BMC Evol Biol. 10:316.
8. Jeong H, Mason SP, Barabasi AL, Oltvai ZN. 2001. Lethality and centrality in protein networks. Nature 411:41-42. (Pubitemid 32428180)
9. Kelly DE, Lamb DC, Kelly SL. 2001. Genome-wide generation of yeast gene deletion strains. Comp Funct Genomics. 2:236-242. (Pubitemid 32815977)
10. Liang H, Li WH. 2009. Functional compensation by duplicated genes in mouse. Trends Genet. 25:441-442.
11. Liao B-Y, Zhang J. 2007. Mouse duplicate genes are as essential as singletons. Trends Genet. 23:378-381. (Pubitemid 47090192)
12. Makino T, Hokamp K, McLysaght A. 2009. The complex relationship of gene duplication and essentiality. Trends Genet. 25:152-155.
13. Ohno S. 1970. Evolution by gene duplication. New York:Springer-Verlag.
14. Simpson EH. 1951. The interpretation of interaction in contingency tables. J R Stat Soc Ser B. 13:238-241.
15. Su Z, Gu X. 2008. Predicting the proportion of essential genes in mouse duplicates based on biased mouse knockout genes. J Mol Evol. 67:705-709.
16. Wolf YI, Novichkov PS, Karev GP, Koonin EV, Lipman DJ. 2009. Inaugural article:the universal distribution of evolutionary rates of genes and distinct characteristics of eukaryotic genes of different apparent ages. Proc Natl Acad Sci U S A. 106:7273-7280.
17. Zotenko E, Mestre J, O'Leary DP, Przytycka TM. 2008. Why do hubs in the yeast protein interaction network tend to be essential:reexamining the connection between the network topology and essentiality. PLoS Comput Biol. 4:e1000140.