The flavonoids casticin and artemetin are poorly extracted and are unstable in an artemisia annua tea infusion

Planta Medica

Volumn 78, Issue 10, 2012, Pages 1024-1026

  Weathers, Pamela J ^a   Towler, Melissa J ^a  

^a WORCESTER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Artemisia annua; artemisinin; Asteraceae; casticin; Compositae; malaria; stability; tea infusion

Indexed keywords

ARTEMETIN; ARTEMISININ; CASTICIN; FLAVONOID; UNCLASSIFIED DRUG;

ARTEMISIA ANNUA; ARTICLE; DRUG DETERMINATION; DRUG EXCRETION; DRUG POTENCY; MASS FRAGMENTOGRAPHY; ROOM TEMPERATURE;

ARTEMISIA ANNUA; ARTEMISININS; BEVERAGES; DRUG STABILITY; DRUG SYNERGISM; FLAVONOIDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MOLECULAR STRUCTURE; PLANT LEAVES; TEMPERATURE; TIME FACTORS;

ARTEMISIA ANNUA; ASTERACEAE; PLASMODIUM FALCIPARUM;

EID: 84863602369     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1314949     Document Type: Article

References (11)

1. Hsu E. The history of qinghao in the Chinese material medica. Trans R Soc Trop Med Hyg: 2006; 100 505 508
2. de Ridder S, van der Kooy F, Verpoorte R. Artemisia annua as a self-treatment for malaria in developing countries. J Ethnopharmacol: 2008; 120 302 314 (Pubitemid 50328629)
3. Efferth T. Artemisinin: a versatile weapon from traditional Chinese medicine. Herbal drugs: ethnomedicine to modern medicine. Berlin, Heidelberg Springer-Verlag: 2009; 173 194
4. Firestone GL, Sundar SN. Anticancer activities of artemisinin and its bioactive derivatives. Expert Rev Mol Med: 2009; 11 e32
5. Ferreira JFS, Luthria DL, Sasaki T, Heyerick A. Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. Molecules: 2010; 15 3135 3170
6. Ferreira J, Peaden P, Keiser J. In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asiminatriloba, and Fumaria officinalis. Parasitol Res: 2011; 109 1585 1592
7. Elford BC, Roberts MF, Phillipson D, Wilson RJM. Potentiation of the antimalarial activity of quinghaosu by methoxylated flavones. Trans R Soc Trop Med: 1987; 81 434 436
8. Liu KCSC, Yang S-L, Roberts MF, Elford BC, Phillipson JD. Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. Plant Cell Rep: 1992; 11 637 640
9. van der Kooy F, Verpoorte R. The content of artemisinin in the Artemisia annua tea infusion. Planta Med: 2011; 77 1754 1756
10. Carbonara T, Pascale R, Argentieri MP, Papadia P, Fanizzi FP, Villanova L, Avato P. Phytochemical analysis of a herbal tea from Artemisia annua L. J Pharm Biomed Anal: 2012; 62 79 86
11. Weathers PJ, Arsenault PR, Covello PS, McMickle A, Teoh KH, Reed DW. Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases. Phytochem Rev: 2011; 10 173 183