Thrombotic events after discontinuing dabigatran: Rebound or resumption?

BMJ (Online)

Volumn 345, Issue 7864, 2012, Pages

  Thorne, Katie M ^a   Dee, Stephen ^b   Jayathissa, Sisira ^b  

^a WELLINGTON HOSPITAL   (New Zealand)

^b HUTT HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; DABIGATRAN; HEPARIN; RIVAROXABAN; XIMELAGATRAN; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE; DRUG DERIVATIVE; N ((2 (((4 (AMINOIMINOMETHYL)PHENYL)AMINO)METHYL) 1 METHYL 1H BENZIMIDAZOL 5 YL)CARBONYL) N 2 PYRIDINYL BETA ALANINE; N-((2-(((4-(AMINOIMINOMETHYL)PHENYL)AMINO)METHYL)-1-METHYL-1H-BENZIMIDAZOL-5-YL)CARBONYL)-N-2-PYRIDINYL-BETA-ALANINE;

DEEP VEIN THROMBOSIS; DRUG SAFETY; DRUG SURVEILLANCE PROGRAM; DRUG WITHDRAWAL; GASTROINTESTINAL SYMPTOM; HEART ATRIUM FIBRILLATION; HEART LEFT VENTRICLE FAILURE; HUMAN; HYPERCOAGULABILITY; KIDNEY DISEASE; LETTER; MIDDLE CEREBRAL ARTERY; PRIORITY JOURNAL; REBOUND; STROKE; TRANSIENT ISCHEMIC ATTACK; AGED; MIDDLE AGED; PATHOLOGY; RECURRENT DISEASE; THROMBOSIS;

AGED, 80 AND OVER; ANTICOAGULANTS; BENZIMIDAZOLES; BETA-ALANINE; HUMANS; MIDDLE AGED; RECURRENCE; THROMBOSIS;

EID: 84863600252     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.e4469     Document Type: Letter

References (5)

1. Delamothe T. From rags to riches: the atrial fibrillation story. BMJ 2012;344:e3871. (7 June.)
2. Eriksson BI, Dahl OE, Rosencher AA, Kurth C, VanDijk SP, Frostick P, et al. Oral dabigatran etexalite vs subcutaneous enoxapirin for the prevention of venous thromboembolism after total knee replacement: the REMODEL randomised trial. J Thromb Haemost 2007;5:2178-85. (Pubitemid 47617868)
3. Hermans C, Claeys D. Review of the rebound phenomenon in new anticoagulant treatments. Curr Med Res Opin 2006;22:471-81.
4. Cundiff D. Clinical evidence for rebound hypercoagulability after discontinuing oral anticoagulants for venous thromboembolism. Medscape J Med 2008;10:258.
5. Hauptmann J. Pharmacokinetics of an emerging new class of anticoagulant/antithrombotic drugs. A review of small-molecule thrombin inhibitors. Eur J Clin Pharmacol 2002;57:751-8. (Pubitemid 34143330)