Immune reconstitution following unmanipulated HLA-Mismatched/Haploidentical transplantation compared with HLA-identical sibling transplantation

Journal of Clinical Immunology

Volumn 32, Issue 2, 2012, Pages 268-280

  Chang, Ying Jun ^a   Zhao, Xiang Yu ^a   Huo, Ming Rui ^a   Xu, Lan Ping ^a   Liu, Dai Hong ^a   Liu, Kai Yan ^a   Huang, Xiao Jun ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

Haploidentical; Hematopoietic stem cell transplantation; HLA identical; Immune reconstitution

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; B LYMPHOCYTE; BLOOD TRANSFUSION; BONE MARROW TRANSPLANTATION; CANCER RELAPSE; CANCER SURVIVAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CHILD; CONTROLLED STUDY; CYTOMEGALOVIRUS; DENDRITIC CELL; FEMALE; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HLA IDENTICAL SIBLING TRANSPLANTATION; HLA MATCHING; HUMAN; HUMAN CELL; IMMUNE RECONSTITUTION; IMMUNITY; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MORTALITY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHOOL CHILD; TRANSPLANTATION; TREATMENT OUTCOME; UNMANIPULATED HLA MISMATCHED HAPLOIDENTICAL TRANSPLANTATION; ALLOTRANSPLANTATION; BIOSYNTHESIS; BLOOD DISEASE; COMPARATIVE STUDY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; IMMUNOLOGY; INFECTION; METABOLISM; MIDDLE AGED; SIBLING; T LYMPHOCYTE SUBPOPULATION; TIME;

CYTOKINE; HLA ANTIGEN;

ADULT; B-LYMPHOCYTES; CYTOKINES; DENDRITIC CELLS; FEMALE; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; HLA ANTIGENS; HUMANS; INFECTION; MALE; MIDDLE AGED; SIBLINGS; T-LYMPHOCYTE SUBSETS; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84863581382     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-011-9630-7     Document Type: Article

References (39)

1. Aversa F. Haploidentical haematopoietic stem cell transplantation for acute leukaemia in adults: experience in Europe and the United States. Bone Marrow Transplant. 2008;41:473-81. (Pubitemid 351386712)
2. Aversa F, Terenzi A, Tabilio A, et al. Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. J Clin Oncol. 2005;23:3447-54.
3. Huang XJ, Liu DH, Liu KY, et al. Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant. 2006;38:291-7.
4. Kang Y, Chao NJ, Aversa F. Unmanipulated or CD34 selected haplotype mismatched transplants. Curr Opin Hematol. 2008;15:561-7.
5. Lu DP, Dong L, Wu T, et al. Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation. Blood. 2006;107:3065-73.
6. Ruggeri L, Capanni M, Urbani E, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002;295:2097-100. (Pubitemid 34229476)
7. Shimazaki C, Ochiai N, Uchida R, et al. Non-T-cell-depleted HLA haploidentical stem cell transplantation in advanced hematologic malignancies based on the feto-maternal microchimerism. Blood. 2003;101:3334-6. (Pubitemid 36858033)
8. van Rood JJ, Loberiza Jr FR, Zhang MJ, et al. Effect of tolerance to noninherited maternal antigens on the occurrence of graftversus- host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling. Blood. 2002;99:1572-7. (Pubitemid 34533028)
9. Ichinohe T, Uchiyama T, Shimazaki C, et al. Feasibility of HLAhaploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism. Blood. 2004;104:3821-8. (Pubitemid 39564463)
10. Huang XJ, Chang YJ. Unmanipulated HLA-mismatched/haploidentical blood and marrow hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2011;17:197-204.
11. Aversa F, Tabilio A, Velardi A, et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl JMed. 1998;339:1186-93. (Pubitemid 28482127)
12. Chang YJ, Zhao XY, Huo MR, et al. Influence of lymphocyte recovery on outcome of haploidentical transplantation for hematologic malignancies. Medicine (Baltimore). 2009;88:322-30.
13. Porrata LF, Inwards DJ, Ansell SM, et al. Early lymphocyte recovery predicts superior survival after autologous stem cell transplantation in non-Hodgkin lymphoma: a prospective study. Biol Blood Marrow Transplant. 2008;14:807-16. (Pubitemid 351773157)
14. Ishaqi MK, Afzal S, Dupuis A, et al. Early lymphocyte recovery post-allogeneic hematopoietic stem cell transplantation is associated with significant graft-versus-leukemia effect without increase in graft-versus-host disease in pediatric acute lymphoblastic leukemia. Bone Marrow Transplant. 2008;41:245-52. (Pubitemid 351260378)
15. Hiwase DK, Hiwase S, Bailey M, et al. Higher infused lymphocyte dose predicts higher lymphocyte recovery, which in turn, predicts superior overall survival following autologous hematopoietic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant. 2008;14:116-24. (Pubitemid 350286748)
16. Xiao-Jun H, Lan-Ping X, Kai-Yan L, et al. HLA-mismatched/ haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for chronic myeloid leukemia: improved outcomes in patients in accelerated phase and blast crisis phase. Ann Med. 2008;40:444-55.
17. Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graftversus- host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med. 1980;69:204-17. (Pubitemid 10036817)
18. Sullivan KM, Agura E, Anasetti C, et al. Chronic graft-versus-host disease and other late complications of bone marrow transplantation. Semin Hematol. 1991;28:250-9.
19. Xiao-Jun H, Lan-Ping X, Kai-Yan L, et al. Partially matched related donor transplantation can achieve outcomes comparable with unrelated donor transplantation for patients with hematologic malignancies. Clin Cancer Res. 2009;15:4777-83.
20. Storek J, Dawson MA, Storer B, et al. Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation. Blood. 2001;97:3380-9.
21. Michie CA, McLean A, Alcock C, et al. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature. 1992;360:264-5.
22. Chang YJ, Zhao XY, Huo MR, et al. Expression profiles of adhesion molecules on naive T cells in bone marrow grafts of healthy donors treated with granulocyte colony-stimulating factor. Transpl Immunol. 2009;21:228-33.
23. Beckebaum S, Zhang X, Chen X, et al. Increased levels of interleukin- 10 in serum from patients with hepatocellular carcinoma correlate with profound numerical deficiencies and immature phenotype of circulating dendritic cell subsets. Clin Cancer Res. 2004;10:7260-9. (Pubitemid 39487713)
24. Chen H, Liu KY, Xu LP, et al. Application of real time polymerase chain reaction to the diagnosis and treatment of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhonghua Xue Ye Xue Za Zhi. 2009;30:77-81.
25. Kim DH, Sohn SK, Won DI, et al. Rapid helper T-cell recovery above 200×10 6/l at 3 months correlates to successful transplant outcomes after allogeneic stem cell transplantation. Bone Marrow Transplant. 2006;37:1119-28. (Pubitemid 43871522)
26. Koehl U, Bochennek K, Zimmermann SY, et al. Immune recovery in children undergoing allogeneic stem cell transplantation: absolute CD8+ CD3+ count reconstitution is associated with survival. Bone Marrow Transplant. 2007;39:269-78. (Pubitemid 46322633)
27. Geddes M, Storek J. Immune reconstitution following hematopoietic stem-cell transplantation. Best Pract Res Clin Haematol. 2007;20:329-48. (Pubitemid 46585969)
28. Storek J, Espino G, Dawson MA, et al. Low B-cell and monocyte counts on day 80 are associated with high infection rates between days 100 and 365 after allogeneic marrow transplantation. Blood. 2000;96:3290-3.
29. Luo XH, Huang XJ, Liu KY, et al. Protective immunity transferred by infusion of cytomegalovirus-specific CD8(+) T cells within donor grafts: its associations with cytomegalovirus reactivation following unmanipulated allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2010;16:994-1004.
30. Casazza JP, Betts MR, Price DA, et al. Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation. J Exp Med. 2006;203:2865-77. (Pubitemid 46026164)
31. Rissoan MC, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science. 1999;283:1183-6.
32. Porta MD, Rigolin GM, Alessandrino EP, et al. Dendritic cell recovery after allogeneic stem-cell transplantation in acute leukemia: correlations with clinical and transplant characteristics. Eur J Haematol. 2004;72:18-25. (Pubitemid 38161108)
33. Tanaka J, Asaka M, Imamura M. T-cell co-signalling molecules in graft-versus-host disease. Ann Hematol. 2000;79:283-90. (Pubitemid 30349018)
34. Harding FA, McArthur JG, Gross JA, et al. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature. 1992;356:607-9.
35. Berger M, Figari O, Bruno B, et al. Lymphocyte subsets recovery following allogeneic bone marrow transplantation (BMT): CD4+ cell count and transplant-related mortality. Bone Marrow Transplant. 2008;41:55-62.
36. Afzal S, Ishaqi MK, Dupuis A, et al. Early lymphocyte recovery after allogeneic hematopoietic SCT is associated with significant GVL effect in pediatric ALL but not acute myelogenous leukemia-update study. Bone Marrow Transplant. 2009;44:799-804.
37. Wang Y, Liu DH, Xu LP, et al. Superior graft-versus-leukemia effect associated with transplantation of haploidentical compared with HLA-identical sibling donor grafts for high-risk acute leukemia: an historic comparison. Biol Blood Marrow Transplant. 2011;17:821-30.
38. Passweg JR, Tichelli A, Meyer-Monard S, et al. Purified donor NK-lymphocyte infusion to consolidate engraftment after haploidentical stem cell transplantation. Leukemia. 2004;18:1835-8. (Pubitemid 39530014)
39. Bao L, Dunham K, Stamer M, et al. Expansion of cytomegalovirus pp 65 and IE-1 specific cytotoxic T lymphocytes for cytomegalovirus-specific immunotherapy following allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2008;14:1156-62.