Vaccine programmes must consider their effect on general resistance

BMJ (Online)

Volumn 345, Issue 7864, 2012, Pages

  Aaby, Peter ^a   Whittle, Hilton ^b   Benn, Christine Stabell ^a,c  

^a Studies of the Epidemiology of Epilepsy in Demographic Surveillance Systems   (Guinea-Bissau)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; DIPHTHERIA PERTUSSIS TETANUS VACCINE; INACTIVATED VACCINE; MEASLES VACCINE; PNEUMOCOCCUS VACCINE; RETINOL; ROTAVIRUS VACCINE;

ARTICLE; BCG VACCINATION; CELLULAR IMMUNITY; CHILD HEALTH CARE; CHILDHOOD MORTALITY; DIPHTHERIA; DRUG EFFICACY; DRUG SAFETY; HEALTH CARE FINANCING; HEALTH CARE POLICY; HUMAN; INFECTION CONTROL; INFECTION PREVENTION; INFECTION RESISTANCE; LOWEST INCOME GROUP; MEASLES; MEASLES VACCINATION; NONHUMAN; PERTUSSIS; PNEUMOCOCCAL INFECTION; PREVENTIVE HEALTH SERVICE; PRIORITY JOURNAL; PUBLIC HEALTH PROBLEM; RISK REDUCTION; ROTAVIRUS INFECTION; SURVIVAL RATE; TETANUS; TH1 CELL; TH2 CELL; TUBERCULOSIS; VIRUS STRAIN; VITAMIN SUPPLEMENTATION;

EID: 84863567200     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.e3769     Document Type: Article

References (23)

1. Horton R, Das P. The vaccine paradox. Lancet 2011;378:296-8.
2. Moxon ER, Das P, Greenwood B, Heymann DL, Horton R, Levine OS, Plotkin S, et al. A call for action for the new decade of vaccines. Lancet 2011;378:298-302.
3. Aaby P, Jensen H, Samb B, Cisse B, Sodeman M, Jakobsen M, et al. Differences in female-male mortality after high-titre measles vaccine and association with subsequent vaccination with diphtheria-tetanus-pertussis and inactivated poliovirus: a re-analysis of the West African studies. Lancet 2003;361:2183-8. (Pubitemid 36782551)
4. Lucero MG, Dulalia VE, Nillos LT, Williams G, Parreño RAN, Nohynek H, et al. Pneumococcal conjugate vaccines for preventing vaccine-type invasive pneumococcal disease and x-ray defined pneumonia in children less than two years of age. Cochrane Database Syst Rev 2009:4:CD004977.
5. Aaby P, Martins CL, Garly ML, Bale C, Andersen A, Rodrigues A, et al. Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial. BMJ 2010;341:c6495.
6. Biering-Sørensen S, Aaby P, Roth A, Ravn H, Napirna BM, Rodrigues A, et al. Small randomised trial among low-birth-weight children of Bacillus Calmette-Guérin vaccination at first health center contact. Pediatr Inf Dis J 2012;31:306-8.
7. Aaby P, Roth A, Ravn H, Napirna BM, Rodrigues A, Lisse IM, et al. Randomised trial of BCG vaccination at birth to low-birth-weight children: beneficial non-specific effects in the neonatal period? J Infect Dis 2011:204:245-51.
8. Benn CS, Fisker A, Roth A, Diness BR, Lausch KR, Ravn H, et al. Randomised trial of vitamin A supplementation and BCG vaccination at birth to low-birth-weight children. BMJ 2010;340:c1101.
9. Aaby P, Ibrahim S, Libman M, Jensen H. The sequence of vaccinations and increased female mortality after high-titre measles vaccine: trials from rural Sudan and Kinshasa. Vaccine 2006;24:2764-71.
10. Aaby P, Jensen H, Gomes J, Fernandes M, Lisse IM. The introduction of diphtheria-tetanus-pertussis vaccine and child mortality in rural Guinea-Bissau: an observational study. Int J Epidemiol 2004,33:374-80. (Pubitemid 38578839)
11. Benn CS, Aaby P, Nielsen J, Binka FN, Ross DA. Does vitamin A supplementation interact with routine vaccinations? An analysis of the Ghana vitamin A supplementation trial. Am J Clin Nutr 2009;90:629-39.
12. Aaby P, Ravn H, Roth A, Rodrigues A, Lisse IM, Diness BR, et al. Early diphtheria-tetanus-pertussis vaccination associated with increased female mortality in a cohort of low-birth-weight children. An observational study within a randomised trial. Arch Dis Child 2012 Feb 13. [Epub ahead of print].
13. Welsh RM, Selin LH. No one is naïve: the significance of heterologous T-cell immunity. Nat Rev Immunol 2002;2:417-26. (Pubitemid 37328749)
14. Shann F. Heterologous immunity and the non-specific effects of vaccines. A major medical advance? Pedr Infect Dis J 2004;23:555-8. (Pubitemid 38802303)
15. Kristensen I, Aaby P, Jensen H. Routine vaccinations and child survival: follow up study in Guinea-Bissau, West Africa. BMJ 2000;321:1435-8.
16. Shann F. The non-specific effects of vaccines. Arch Dis Child 2010;95:662-7.
17. Mathurin KS, Martens GW, Kornfeld H, Welsh RM. CD4 T-cell-mediated heterologous immunity between mycobacteria and poxviruses. J Virol 2009;83:3528-39.
18. Kasongo Project Team. Influence of measles vaccination on survival pattern of 7-35-month-old children in Kasongo, Zaire. Lancet 1981;i:764-7.
19. Aaby P, Bukh J, Lisse IM, Smits AJ. Measles vaccination and reduction in child mortality: a community study from Guinea-Bissau. J Infect 1984;8:13-21. (Pubitemid 14223302)
20. Desgrées du Loû A, Pison G, Aaby P. The role of immunizations in the recent decline in childhood mortality and the changes in the female/male mortality ratio in rural Senegal. Am J Epidemiol 1995;142:643-52.
21. Shann F, Nohynek H, Scott JA, Hesseling A, Flanagan KL, Working Group on Nonspecific Effects of Vaccines. Randomized trials to study the nonspecific effects of vaccines in children in low-income countries. Pediatr Infect Dis J 2010;29:457-61.
22. De Quadros CA, Izurieta H, Venczel L, Carrasco P. Measles eradication in the Americas: progress to date. J Infect Dis 2004;189(suppl 1):S227.
23. Roth A, Benn CB, Ravn H, Rodrigues A, Lisse IM, Yazdanbakhsh M, et al. Effect of revaccination with BCG in early childhood on mortality: randomised trial in Guinea-Bissau. BMJ 2010;340:c809.