Investigation of parameters highlighting drug induced small changes of the T-wave's morphology for drug safety studies

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volumn , Issue , 2011, Pages 3796-3799

  Baas, Tobias ^a   Grafe, Ksenija ^a   Khawaja, Antoun ^b   Dössel, Olaf ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b Biosigna   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL STUDY; CONTROL STUDIES; DESCRIPTORS; DRUG SAFETY; FOOD AND DRUG ADMINISTRATION; HEART RATES; MOXIFLOXACIN; SINGLE-DOSE;

ELECTROCARDIOGRAPHY;

MORPHOLOGY;

ANTIINFECTIVE AGENT; HETEROCYCLIC COMPOUND; MOXIFLOXACIN; QUINOLINE DERIVATIVE;

ARTICLE; ELECTROCARDIOGRAPHY; FEMALE; FOOD AND DRUG ADMINISTRATION; HEART VENTRICLE TACHYCARDIA; HUMAN; MALE; METHODOLOGY; PATHOPHYSIOLOGY; TORSADE DES POINTES; UNITED STATES;

ANTI-INFECTIVE AGENTS; AZA COMPOUNDS; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; MALE; QUINOLINES; TACHYCARDIA, VENTRICULAR; TORSADES DE POINTES; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 84863564070     PISSN: 1557170X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2011.6090769     Document Type: Conference Paper

References (6)

1. W. Zareba, Drug induced QT prolongation, Cardiology Journal, vol. 14 2007 pp 523-533.
2. US Food and Drug Administration, Guidance for Industry: E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs, http://www.fda.gov/downloads/RegulatoryInformation/ Guidances/ucm129357.pdf, 2005
3. J. P. Couderc, "Measurement and regulation of cardiac ventricular repolarization: from the QT interval to repolarization morphology", Phil. Trans. R. Soc. A, vol 367 2009 pp 1283-1299.
4. C. Graff, J. Matz, E. B. Christensen, M. P. Andersen, J. K. Kanters, E. Toft, S. Pehrson, T. B. Hardahl, J. Nielsen, and J. J. Struijk, "Quantitative Analysis of T-wave Morphology Increases Confidence in Drug-Induced Cardiac Repolarization Abnormalities: Evidence From the Investigational IKr Inhibitor Lu 35-138", J Clin Pharmacol, vol 49 2009 pp 1331-1342.
5. J. P. Couderc, "A scientific repository to support the research and development of technologies related to quantitative electrocardiography: The Telemetric and Holter ECG Warehouse (THEW)", Cardiology Journal, vol 17 2010 pp 416-419.
6. T. Baas, F. Gravenhorst, R. Fischer, A. Khawaja, and O. Dössel, "Comparison of three T-Wave Delineation Algorithms based on Wavelet Filterbank, Correlation and PCA", Computing in Cardiology, vol 37 2010 pp 361-364.