Reduced GABA concentration in attention-deficit/hyperactivity disorder

Archives of General Psychiatry

Volumn 69, Issue 7, 2012, Pages 750-753

  Edden, Richard A E ^a,b   Crocetti, Deana ^b   Zhu, He ^a,b   Gilbert, Donald L ^c   Mostofsky, Stewart H ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID;

ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GABAERGIC SYSTEM; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SCHOOL CHILD;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN; CHILD; CROSS-SECTIONAL STUDIES; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE;

EID: 84863545490     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archgenpsychiatry.2011.2280     Document Type: Article

References (22)

1. Tannock R. Attention deficit hyperactivity disorder: advances in cognitive, neurobiological, and genetic research. J Child Psychol Psychiatry. 1998;39(1):65-99. (Pubitemid 28059670)
2. Brown RT, Freeman WS, Perrin JM, Stein MT, Amler RW, Feldman HM, Pierce K, Wolraich ML. Prevalence and assessment of attention-deficit/hyperactivity disorder in primary care settings. Pediatrics. 2001;107(3):E43. Accessed March 29, 2012.
3. Barkley RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull. 1997;121(1):65-94. (Pubitemid 127705285)
4. Boy F, Evans CJ, Edden RA, Lawrence AD, Singh KD, Husain M, Sumner P. Dorsolateral prefrontal γ-aminobutyric acid in men predicts individual differences in rash impulsivity. Biol Psychiatry. 2011;70(9):866-872.
5. Boy F, Evans CJ, Edden RA, Singh KD, Husain M, Sumner P. Individual differences in subconscious motor control predicted by GABA concentration in SMA. Curr Biol. 2010;20(19):1779-1785.
6. Marenco S, Savostyanova AA, van der Veen JW, Geramita M, Stern A, Barnett AS, Kolachana B, Radulescu E, Zhang F, Callicott JH, Straub RE, Shen J, Weinberger DR. Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT. Neuropsychopharmacology. 2010;35(8):1708-1717.
7. Rothman DL, Petroff OA, Behar KL, Mattson RH. Localized 1H NMR measurements of γ-aminobutyric acid in human brain in vivo. Proc Natl Acad Sci U S A. 1993;90(12):5662-5666. (Pubitemid 23176221)
8. Mescher M, Merkle H, Kirsch J, Garwood M, Gruetter R. Simultaneous in vivo spectral editing and water suppression. NMR Biomed. 1998;11(6):266-272. (Pubitemid 28465190)
9. Sumner P, Edden RA, Bompas A, Evans CJ, Singh KD. More GABA, less distraction: a neurochemical predictor of motor decision speed. Nat Neurosci. 2010;13(7):825-827.
10. Gilbert DL, Isaacs KM, Augusta M, Macneil LK, Mostofsky SH. Motor cortex inhibition: a marker of ADHD behavior and motor development in children. Neurology. 2011;76(7):615-621.
11. Ziemann U, Lönnecker S, Steinhoff BJ, Paulus W. The effect of lorazepam on the motor cortical excitability in man. Exp Brain Res. 1996;109(1):127-135. (Pubitemid 26119972)
12. Biederman J, Faraone SV, Keenan K, Benjamin J, Krifcher B, Moore C, Sprich- Buckminster S, Ugaglia K, Jellinek MS, Steingard R, Spencer T, Norman D, Kolodny R, Kraus I, Perrin J, Keller MB, Tsuang MT. Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder: patterns of comorbidity in probands and relatives psychiatrically and pediatrically referred samples. Arch Gen Psychiatry. 1992;49(9):728-738.
13. Faraone SV, Biederman J, Chen WJ, Milberger S, Warburton R, Tsuang MT. Genetic heterogeneity in attention-deficit hyperactivity disorder (ADHD): gender, psychiatric comorbidity, and maternal ADHD. J Abnorm Psychol. 1995;104(2):334-345.
14. Petersen AC. A self-report measure of pubertal status: reliability, validity, and initial norms. J Youth Adolesc. 1988;17(1):117-133.
15. Evans CJ, McGonigle DJ, Edden RA. Diurnal stability of γ-aminobutyric acid concentration in visual and sensorimotor cortex. J Magn Reson Imaging. 2010;31(1):204-209.
16. Puts NA, Edden RA, Evans CJ, McGlone F, McGonigle DJ. Regionally specific human GABA concentration correlates with tactile discrimination thresholds. J Neurosci. 2011;31(46):16556-16560.
17. Tkác I, Starcuk Z, Choi IY, Gruetter R. In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med. 1999;41(4):649-656. (Pubitemid 29205710)
18. Muthukumaraswamy SD, Edden RA, Jones DK, Swettenham JB, Singh KD. Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans. Proc Natl Acad Sci U S A. 2009;106(20):8356- 8361.
19. Anderson SA, Qiu M, Bulfone A, Eisenstat DD, Meneses J, Pedersen R, Rubenstein JL. Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons. Neuron. 1997;19(1):27-37. (Pubitemid 27332991)
20. Courvoisie H, Hooper SR, Fine C, Kwock L, Castillo M. Neurometabolic functioning and neuropsychological correlates in children with ADHD-H: preliminary findings. J Neuropsychiatry Clin Neurosci. 2004;16(1):63-69. (Pubitemid 38233365)
21. Hammerness P, Biederman J, Petty C, Henin A, Moore CM. Brain biochemical effects of methylphenidate treatment using proton magnetic spectroscopy in youth with attention-deficit hyperactivity disorder: a controlled pilot study. CNS Neurosci Ther. 2012;18(1):34-40.
22. Perlov E, Philipsen A, Matthies S, Drieling T, Maier S, Bubl E, Hesslinger B, Buechert M, Henning J, Ebert D, Tebartz Van Elst L. Spectroscopic findings in attention-deficit/hyperactivity disorder: review and meta-analysis. World J Biol Psychiatry. 2009;10(4, pt 2):355-365.