Potential inhibitory effect of LASSBio-596, a new thalidomide hybrid, on inflammatory corneal angiogenesis in rabbits

Ophthalmic Research

Volumn 48, Issue 4, 2012, Pages 177-185

  Ribeiro, Joao Crispim M L ^a,c   Vagnaldo Fechine, Francisco ^a   Ribeiro, Mariana Zaira M L ^a   Barreiro, Eliezer J ^b   Moreira Lima, Lidia ^b   Ricardo, Nagila M P S ^a   Amaral De Moraes, Maria Elisabete ^a   Odorico De Moraes, Manoel ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c NONE   (Brazil)

Author keywords

Inflammatory corneal angiogenesis; Rabbits; Thalidomide hybrid

Indexed keywords

ALKALINE CERAMIDASE; ANTIINFLAMMATORY AGENT; DEXAMETHASONE; EYE DROPS; LASS BIO 596; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUTERIZATION; COMPUTER PROGRAM; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; DRUG EFFECT; IMAGE ANALYSIS; INFLAMMATORY CORNEAL ANGIOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

EID: 84863530416     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000337137     Document Type: Article

References (27)

1. Hanahan D, Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-364. (Pubitemid 26272076)
2. Auerbach R, Lewis R, Shinners B, Kubai L, Akhtar N: Angiogenesis assays: a critical overview. Clin Chem 2003; 49: 32-40. (Pubitemid 36078551)
3. Papetti M, Herman IM: Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol 2002; 282: 947-970.
4. Folkman J: Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med 1995; 333: 1757-1763.
5. Carmeliet P: Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000; 6: 389-395. (Pubitemid 30208155)
6. Joussen AM, Beecken WD, Moromizato Y, Schwartz A, Kirchhof B, Poulaki V: Inhibition of inflammatory corneal angiogenesis by TNP-470. Invest Ophthalmol Vis Sci 2001; 42: 2510-2516. (Pubitemid 32954856)
7. Yoshida S, Yoshida A, Matsui H, Takada Y, Ishibashi T: Involvement of macrophage chemotactic protein-1 and interleukin-1beta during inflammatory but not basic fibroblast growth factor-dependent neovascularization in the mouse cornea. Lab Invest 2003; 83: 927-938. (Pubitemid 36899060)
8. Poulaki V, Mitsiades N, Kruse FE, Radetzky S, Iliaki E, Kirchhof B, et al: Activin a in the regulation of corneal neovascularization and vascular endothelial growth factor expression. Am J Pathol 2004; 164: 1293-1302. (Pubitemid 38387795)
9. Adamis AP, Aiello LP, D'Amato RA: Angiogenesis and ophthalmic disease. Angiogenesis 1999; 3: 9-14. (Pubitemid 129644776)
10. Lima LM, Castro P, Machado AL, Fraga CA, Lugnier C, de Moraes VL, et al: Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues. Bioorg Med Chem 2002; 10: 3067-3073. (Pubitemid 34761888)
11. Rocco PR, Momesso DP, Figueira RC, Ferreira HC, Cadete RA, Legora-Machado A, et al: Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury. Eur Respir J 2003; 22: 20-27. (Pubitemid 36896466)
12. Campos HS, Xisto DG, Oliveira MB, Teixeira I, Negri EM, Mauad T, et al: Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma. Braz J Med Biol Res 2006; 39: 283-287.
13. Fechine-Jamacaru FV, Fechine Junior JU, de Moraes Filho MO: Model of inflammatory angiogenesis in rabbit cornea induced by punctual alkaline cauterization. Acta Cir Bras 2005; 20: 64-73.
14. Edelman JL, Castro MR, Wen Y: Correlation of VEGF expression by leukocytes with the growth and regression of blood vessels in the rat cornea. Invest Ophthalmol Vis Sci 1999; 40: 1112-1123. (Pubitemid 29211448)
15. Usui T, Sugisaki K, Amano S, Jang WD, Nishiyama N, Kataoka K: New drug delivery for corneal neovascularization using polyion complex micelles. Cornea 2005; 24: 39-42.
16. Folkman J, Ingber DE: Angiostatic steroids. Method of discovery and mechanism of action. Ann Surg 1987; 206: 374-383.
17. Proia AD, Hirakata A, McInnes JS, Scroggs MW, Parikh I: The effect of angiostatic steroids and cyclodextrin tetradecasulfate on corneal neovascularization in the rat. Exp Eye Res 1993; 57: 693-698. (Pubitemid 24039473)
18. Rhen T, Cidlowski JA: Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 2005; 353: 1711-1723.
19. Nakao S, Hata Y, Miura M, Noda K, Kimura YN, Kawahara S, et al: Dexamethasone inhibits interleukin-1-induced corneal neovascularization: role of nuclear factor-Bactivated stromal cells in inflammatory angiogenesis. Am J Pathol 2007; 171: 1058-1065. (Pubitemid 47441002)
20. Macpherson GR, Franks M, Tomoaia-Cotisel A, Ando Y, Price DK, Figg WD: Current status of thalidomide and its role in the treatment of metastatic prostate cancer. Crit Rev Oncol Hematol 2003; 46: 49-57.
21. Eleutherakis-Papaiakovou V, Bamias A, Dimopoulos MA: Thalidomide in cancer medicine. Ann Oncol 2004; 15: 1151-1160. (Pubitemid 39199301)
22. Kenyon BM, Browne F, D'Amato RJ: Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp Eye Res 1997; 64: 971-978. (Pubitemid 27314772)
23. Gasparini G, Longo R, Fanelli M, Teicher BA: Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and open questions. J Clin Oncol 2005; 23: 1295-1311. (Pubitemid 46202288)
24. D'Amato RJ, Loughnan MS, Flynn E, Folkman J: Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA 1994; 91: 4082-4085. (Pubitemid 24139577)
25. Carvalho GMC, Oliveira VR, Soares RM, Azevedo SMFO, Lima LM, Barreiro EJ, et al: Can LASSBio 596 and dexamethasone treat acute lung and liver inflammation induced by microcystin-LR? Toxicon 2010; 56: 604-612.
26. Casquilho NV, Carvalho GMC, Alves JLCR, Machado MN, Soares RM, Azevedo SMFO, et al: LASSBio 596 per os avoids pulmonary and hepatic inflammation induced by microcystin-LR. Toxicon 2011; 58: 195-201.
27. Joussen AM, Germann T, Kirchhof B: Effect of thalidomide and structurally related compounds on corneal angiogenesis is comparable to their teratological potency. Graefes Arch Clin Exp Ophthalmol 1999; 237: 952-961. (Pubitemid 30021284)