Activated hepatic stellate cells: Negative regulators of hepatocyte proliferation in liver diseases

Hepatology

Volumn 56, Issue 1, 2012, Pages 389-391

  Chung, Chuhan ^a   Iwakiri, Yasuko ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; SEROTONIN 2B RECEPTOR; TRANSCRIPTION FACTOR JUND; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL PROLIFERATION; DNA SYNTHESIS; LIVER CELL; LIVER CIRRHOSIS; LIVER INJURY; LIVER REGENERATION; NONHUMAN; PATHOPHYSIOLOGY; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RECEPTOR BINDING; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; STELLATE CELL; THROMBOCYTE AGGREGATION;

EID: 84863527283     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25761     Document Type: Article

References (14)

1. Wallace K, Burt AD, Wright MC. Liver fibrosis. Biochem J 2008; 411: 1-18.
2. Marshall A, Rushbrook S, Davies SE, Morris LS, Scott IS, Vowler SL, et al. Relation between hepatocyte G1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection. Gastroenterology 2005; 128: 33-42.
3. Roskams T. Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene 2006; 25: 3818-3822.
4. Ebrahimkhani MR, Oakley F, Murphy LB, Mann J, Moles A, Perugorria MJ, et al. Stimulating healthy tissue regeneration by targeting the 5-HTB receptor in chronic liver disease. Nat Med 2011; 17: 1668-1673.
5. Seuwen K, Pouyssegur J. Serotonin as a growth factor. Biochem Pharmacol 1990; 39: 985-990.
6. Fanburg BL, Lee SL. A new role for an old molecule: serotonin as a mitogen. Am J Physiol 1997; 272: L795-L806.
7. Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, et al. Platelet-derived serotonin mediates liver regeneration. Science 2006; 312: 104-107.
8. Ruddell RG, Oakley F, Hussain Z, Yeung I, Bryan-Lluka LJ, Ramm GA, et al. A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Am J Pathol 2006; 169: 861-876.
9. Nocito A, Georgiev P, Dahm F, Jochum W, Bader M, Graf R, et al. Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice. HEPATOLOGY 2007; 45: 369-376.
10. Balasubramanian S, Paulose CS. Induction of DNA synthesis in primary cultures of rat hepatocytes by serotonin: possible involvement of serotonin S2 receptor. HEPATOLOGY 1998; 27: 62-66.
11. Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 2010; 176: 2-13.
12. Wanless IR, Wong F, Blendis LM, Greig P, Heathcote EJ, Levy G. Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension. HEPATOLOGY 1995; 21: 1238-1247.
13. Palmer MJ. Leads for the treatment of pulmonary hypertension. Expert Opin Ther Pat 2009; 19: 575-592.
14. Porvasnik SL, Germain S, Embury J, Gannon KS, Jacques V, Murray J, et al. PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. J Pharmacol Exp Ther 2010; 334: 364-372.