Morphometric and immunohistochemical study of cholangiolocellular carcinoma: Comparison with non-neoplastic cholangiole, interlobular duct and septal duct

Journal of Hepato-Biliary-Pancreatic Sciences

Volumn 19, Issue 3, 2012, Pages 289-296

  Maeno, Sawako ^a   Kondo, Fukuo ^a   Sano, Keiji ^a   Takada, Tadahiro ^a   Asano, Takehide ^b  

^a TEIKYO UNIVERSITY   (Japan)

^b SAKURA NATIONAL HOSPITAL   (Japan)

Author keywords

Cholangiole; Cholangiolocellular carcinoma; Immunohistochemistry; Interlobular duct; Morphometry

Indexed keywords

ALPHA FETOPROTEIN; CELL MARKER; CYTOKERATIN 7; EPITHELIAL MEMBRANE ANTIGEN; MUCIN 1; PROTEIN HEP PAR 1; PROTEINASE ACTIVATED RECEPTOR 1; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHOLANGIOLOCELLULAR CARCINOMA; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CANCER; MALE; MORPHOMETRICS;

AGED; AGED, 80 AND OVER; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CHOLANGIOCARCINOMA; DIAGNOSIS, DIFFERENTIAL; FEMALE; HEPATOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-19; KERATIN-7; LIVER NEOPLASMS; MALE; MIDDLE AGED; MUCIN-1; PROTO-ONCOGENE PROTEINS C-KIT; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 84863478787     PISSN: 18686974     EISSN: 18686982     Source Type: Journal    
DOI: 10.1007/s00534-011-0483-5     Document Type: Article

References (17)

1. Steiner PE, Higginson J. Cholangiolocellular carcinoma of the liver. Cancer. 1959;12:753-9.
2. Nakanuma Y, Leong ASY, Sripa B, Ponchon T, Vatanasapt V, Ishak KG. Intrahepatic cholangiocarcinoma. In: Hamilton SR, Altonen LA, editors. World health organization classification of tumors. Pathology and genetics of tumours of the digestive sys-tem. Lyon: International Agency for Research on Cancer; 2000. p. 173-80.
3. Theise ND, Nakashima O, Park YN, Nakanuma Y. Combined hepatocellular-cholangiocarcinoma. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. World health organization classification of tumors. WHO classification of tumors of the digestive system. Lyon: International Agency for Research on Cancer; 2010. p. 225-7
4. Liver Cancer Study Group of Japan. The general rules for the clinical and pathological study of primary liver cancer. 5th ed. Revised version. Tokyo: Kanehara; 2009. p. 46.
5. Shiota K, Taguchi J, Nakashima O, Nakashima M, Kojiro M. Clinicopathologic study on cholangiolocellular carcinoma. Oncol Rep. 2001;8(2):263-8.
6. Komuta M, Spee B, Vander Borght S, De Vos R, Verslype C, Aerts R, et al. Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. Hepatology. 2008;47:1544-56.
7. Kozaka K, Sasaki M, Fujii T, Harada K, Zen Y, Sato Y, et al. A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive pro-liferating bile ductules: 'bile ductular carcinoma'. Histopathology. 2007;51:390-400.
8. Motosugi U, Ichikawa T, Nakajima H, Araki T, Matsuda M, Suzuki T, et al. Cholangiolocellular carcinoma of the liver: imaging findings. J Comput Assist Tomogr. 2009;33:682-8.
9. Asayama Y, Tajima T, Okamoto D, Nishie A, Ishigami K, Ushijima Y, et al. Imaging of cholangiolocellular carcinoma of the liver. Eur J Radiol. 2010;75:e120-5.
10. Fukukura Y, Hamanoue M, Fujiyoshi F, Sasaki M, Haruta K, Inoue H,etal. Cholangiolocellular carcinoma of the liver: CT and MR findings. J Comput Assist Tomogr. 2000;24:809-12.
11. Desmet VJ, Roskams T, De Vos R. Normal anatomy in gall bladder and bile ducts. In: LaRusso N, editor. Vol 6 of the series. Gastroenterology and Hepatology. The comprehensive visual reference. Philadelphia: Current Medicine; 1997. p. 1-29.
12. Roskams T, Desmet VJ, Verslype C. Development, structure and function of the liver. In: Burt AD, Portman BC, Ferrel LD, edi-tors. MacSween's pathology of the liver. 5th ed. Philadelphia: Churchill Livingstone Elsevier; 2007. p. 1-73.
13. Abramoff MD, Magalhaes PJ, Ram SJ. Image processing with Image J. Biophotonics Int. 2004;11:36-42.
14. Theise ND, Yao JL, Harada K, Hytiroglou P, Portmann B, Thung SN, et al. Hepatic ''stem cell'' malignacies in adults four cases. Histopathology. 2003;43:263-71.
15. Kondo F, Wada K, Kondo Y. Morphometric analysis ofhepato-cellular carcinoma. Virchows Arch A Pathol Anat Histopathol. 1988;413:425-30.
16. Shibuya M, Kondo F, Sano K, Takada T, Asano T. Immunohis-tochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma. J Hepatobiliary Pancreat Sci. 2011;18:537-43.
17. Nakano M. Histopathological characteristic of cholangiolocellu-lar carcinoma. Tan To Sui (Biliary Tract and Pancreas). 2004;25:343-9. (in Japanese).