A randomized, double-blind, placebo-controlled, crossover, dose-ranging multicenter study to determine the effect of sublingual nitroglycerin spray on exercise capacity in patients with chronic stable angina

Clinical Medicine Insights: Cardiology

Volumn 6, Issue , 2012, Pages 87-95

  Thadani, Udho ^a   Wittig, Thomas ^b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b Arzt für Allgemeinmedizin   (Germany)

Author keywords

Chronic stable angina; Optimal medical therapy; Sublingual nitroglycerin spray

Indexed keywords

GLYCERYL TRINITRATE; PLACEBO;

ADULT; AEROSOL; AGED; ARTICLE; CARDIOVERSION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; EXERCISE; EXERCISE DURATION; EXERCISE TOLERANCE; FEMALE; HEART ATRIUM FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPEN STUDY; OUTCOME ASSESSMENT; PHARMACOLOGIC STRESS TESTING; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; ST SEGMENT DEPRESSION; STABLE ANGINA PECTORIS; SYSTOLIC BLOOD PRESSURE; TIME; TIME TO ONSET ANGINA; TIME TO ONSET MODERATE ANGINA;

EID: 84863475925     PISSN: 11795468     EISSN: 11795468     Source Type: Journal    
DOI: 10.4137/CMC.S9132     Document Type: Article

References (35)

1. Beltrame JF, Weekes AJ, Morgan C, Tavella R, Spertus JA. The prevalence of weekly angina among patients with chronic stable angina in primary care practices. Arch Intern Med. 2009;169(16):1491-9.
2. Deedwania PC, Carbajal EV. Medical therapy versus myocardial revascularization in chronic coronary syndrome and stable angina. Am J Med. 2011;124(8):681-8.
3. Thadani U. Current medical management of chronic stable angina. J Cardiovasc Pharmacol Ther. 2004;9 Suppl 1:S11-29, quiz S98-S99.
4. Smith SC Jr, Allen J, Blair SN, et al. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update endorsed by the National Heart, Lung, and Blood Institute. J Am Coll Cardiol. 2006;47(10):2130-9.
5. Smith SC Jr, Benjamin EJ, Bonow RO, et al. AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2011 Update A Guideline From the American Heart Association and American College of Cardiology Foundation Endorsed by the World Heart Federation and the Preventive Cardiovascular Nurses Association. J Am Coll Cardiol. 2011;58(23):2432-46.
6. Fox K, Garcia MA, Ardissino D, et al. Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J. 2006;27(11):1341-81.
7. Katritsis DG, Ioannidis JP. Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis. Circulation. 2005;111(22):2906-12.
8. Boden WE, O'Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. New Engl J Med. 2007;356(15): 1503-16.
9. Weintraub WS, Spertus JA, Kolm P, et al. Effect of PCI on quality of life in patients with stable coronary disease. New Engl J Med. 2008; 359(7):677-87.
10. Boden WE, O'Rourke RA, Teo KK, et al. Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial Veterans Affairs Cooperative Studies Program no. 424. Am Heart J. 2006;151:1173-9.
11. Kones R. Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization. Vasc Health Risk Manag. 2010;6:749-74.
12. Graboys TB, Lown B. Cardiology patient page. Nitroglycerin: the "mini" wonder drug. Circulation. 2003;108(11):e78-9.
13. Kolenda KD. Glycerol trinitrate and coronary heart disease. Value of prophylactic administration within the scope of exercise therapy. Fortschr Med. 1998;116(20-1):41-2.
14. Kimchi A, Lee G, Amsterdam E, Fujii K, Krieg P, Mason DT. Increased exercise tolerance after nitroglycerin oral spray: a new and effective therapeutic modality in angina pectoris. Circulation. 1983;67(1):124-7.
15. Stuart RJ Jr, Ellestad MH. National survey of exercise stress testing facilities. Chest. 1980;77(1):94-7.
16. Parker JO, Vankoughnett KA, Farrell B. Nitroglycerin lingual spray: clinical efficacy and dose-response relation. Am J Cardiol. 1986;57(1):1-5.
17. Thadani U, Parker JO. Influence of glyceryl trinitrate during supine and upright exercise in patients with angina pectoris. Br Heart J. 1978; 40(11):1229-36.
18. Serruys PW, Unger F, Sousa JE, et al. Comparison of coronary-artery bypass surgery and stenting for the treatment of multivessel disease. New Engl J Med. 2001;344(15):1117-24.
19. Holubkov R, Laskey WK, Haviland A, et al. Angina 1 year after percutaneous coronary intervention: a report from the NHLBI Dynamic Registry. Am Heart J. 2002;144(5):826-33.
20. Gibbons RJ, Abrams J, Chatterjee K, et al. ACC/AHA 2002 guideline update for the management of patients with chronic stable angina-summary article: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable Angina). J Am Coll Cardiol. 2003;41(1):159-68.
21. Wittig T, Beuscher N. Increased physical performance following administration of glycerol trinitrate in spray form. Fortschritte der Medizin. 1999;117:109-13.
22. Fletcher GF, Froelicher VF, Hartley LH, Haskell WL, Pollock ML. Exercise standards. A statement for health professionals from the American Heart Association. Circulation. 1990;82(6):2286-322.
23. Skalidis EI, Vardas PE. Guidelines on the management of stable angina pectoris. Eur Heart J. 2006;27(21):2606, author reply 2606-7.
24. Hambrecht R, Walther C, Mobius-Winkler S, et al. Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial. Circulation. 2004;109(11):1371-8.
25. Taylor RS, Brown A, Ebrahim S, et al. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 2004;116(10):682-92.
26. Myers J. Cardiology patient pages. Exercise and cardiovascular health. Circulation. 2003;107(1):e2-5.
27. Thompson PD. Exercise prescription and proscription for patients with coronary artery disease. Circulation. 2005;112(15):2354-63.
28. Gardner AW, Montgomery PS, Ritti-Dias RM, Thadani U. Exercise performance, physical activity, and health-related quality of life in participants with stable angina. Angiology. 2011;62(6):461-6.
29. Thadani U, Lipicky RJ. Short and long-acting oral nitrates for stable angina pectoris. Cardiovasc Drugs Ther. 1994;8(4):611-23.
30. Thadani U. Management of patients with chronic stable angina at low risk for serious cardiac events. Am J Cardiol. 1997;79(12B):24-30.
31. Fraker TD Jr, Fihn SD, Gibbons RJ, et al. 2007 chronic angina focused update of the ACC/AHA 2002 Guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 Guidelines for the management of patients with chronic stable angina. Circulation. 2007;116(23):2762-72.
32. Daly C, Clemens F, Lopez-Sendon JL, et al. The impact of guideline compliant medical therapy on clinical outcome in patients with stable angina: findings from the Euro Heart Survey of stable angina. Eur Heart J. 2006;27(11):1298-304.
33. Lappe JM, Muhlestein JB, Lappe DL, et al. Improvements in 1-year cardiovascular clinical outcomes associated with a hospital-based discharge medication program. Ann Intern Med. 2004;141(6):446-53.
34. Frye RL, August P, Brooks MM, et al. A randomized trial of therapies for type 2 diabetes and coronary artery disease. New Engl J Med. 2009; 360(24):2503-15.
35. Carasso S, Markiewicz W. Medical treatment of patients with stable angina pectoris referred for coronary angiography: failure of treatment or failure to treat. Clin Cardiol. 2002;25(9):436-41.