Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods

Mutagenesis

Volumn 27, Issue 4, 2012, Pages 453-462

  Herrmann, Kristin ^a   Engst, Wolfram ^a   Appel, Klaus E ^b   Monien, Bernhard H ^a   Glatt, Hansruedi ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1' HYDROXYMETHYLEUGENOL; 3' HYDROXYMETHYLISOEUGENOL; ALKENYLBENZENE DERIVATIVE; BENZENE DERIVATIVE; CARCINOGEN; METHYLEUGENOL; MUTAGENIC AGENT; N2 (METHYLISOEUGENOL 3' YL) 2' DEOXYGUANOSINE; N6 (METHYLISOEUGENOL 3' YL) 2' DEOXYADENOSINE; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 1A2; SULFOTRANSFERASE 1A3; SULFOTRANSFERASE 1C1; SULFOTRANSFERASE 1C2; SULFOTRANSFERASE 1C3; SULFOTRANSFERASE 1D1; SULFOTRANSFERASE 1E1; SULFOTRANSFERASE 2A1; SULFOTRANSFERASE 2B1B; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA ADDUCT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN; HYDROXYLATION; METABOLITE; MOUSE; MUTAGEN TESTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA TYPHIMURIUM; SENSITIVITY AND SPECIFICITY; SPICE; SULFATION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; EUGENOL; GENE EXPRESSION REGULATION; HUMANS; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MUTAGENICITY TESTS; MUTAGENS; RATS; SALMONELLA TYPHIMURIUM; SULFOTRANSFERASES; TANDEM MASS SPECTROMETRY;

ANIMALIA; MURINAE; MUS; RATTUS; SALMONELLA TYPHIMURIUM;

EID: 84863458837     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/ges004     Document Type: Article

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