Phosphoprotein associated with glycosphingolipid microdomains 1 inhibits the proliferation and invasion of human prostate cancer cells in vitro through suppression of Ras activation

Oncology Reports

Volumn 28, Issue 2, 2012, Pages 606-614

  Yu, Wenjuan ^a,b   Wang, Yuewei ^a   Gong, Miaozi ^b   Pei, Fei ^b   Zheng, Jie ^b  

^a QINGDAO UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Cancer metastasis; Gene; PAG; Prostate cancer; RasGAP

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; F ACTIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID MICRODOMAIN 1; RAS PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER INVASION; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME REPRESSION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; PSEUDOPODIUM; SIGNAL TRANSDUCTION;

CELL GROWTH PROCESSES; CELL LINE, TUMOR; GLYCOSPHINGOLIPIDS; HUMANS; MALE; MEMBRANE MICRODOMAINS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; RAS PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84863443014     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1848     Document Type: Article

References (17)

1. Liu YX, Zheng J and Fang WG: Isolation and characterization of human prostate cancer cell subclones with different metastatic potential. Chin J Pathol 28: 361-364, 1999.
2. Svec A: Phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk-binding protein: a protein that matters. Pathol Res Pract 204: 785-792, 2008.
3. Brdickova N, Brdicka T, Andera L, Spicka J, Angelisova P, Milgram SL and Horejsi V: Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. FEBS Lett 507: 133-136, 2001. (Pubitemid 33001529)
4. Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, Nagai K, Tarakhovsky A and Okada M: Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature 404: 999-1003, 2000. (Pubitemid 30243594)
5. Takeuchi S, Takayama Y, Ogawa A, Tamura K and Okada M: Transmembrane phosphoprotein cbp positively regulates the activity of the carboxyl-terminal src kinase Csk. J Biol Chem 275: 29183-29186, 2000. (Pubitemid 32043785)
6. Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Hilgert I, Cerny J, Drbal K, Kuramitsu Y, Kornacker B, Horejsi V and Schraven B: Phosphoprotein associated with glycosphingolipid- enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med 191: 1591-1604, 2000. (Pubitemid 30257355)
7. Torgersen KM, Vang T, Abrahamsen H, Yaqub S, Horejsi V, Schraven B, Rolstad B, Mustelin T and Tasken K: Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts. J Biol Chem 276: 29313-29318, 2001.
8. Jiang LQ, Feng X, Zhou W, Knyazev PG, Ullrich A and Chen Z: Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation. Oncogene 25: 5495-5506, 2006. (Pubitemid 44344100)
9. Smida M, Posevitz-Fejfar A, Horejsi V, Schraven B and Lindquist JA: A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation. Blood 110: 596-615, 2007.
10. Durrheim GA, Garnett D, Dennehy KM and Beyers AD: Thy-1 associated pp85-90 is a potential docking site for SH2 domain-containing signal transduction molecules. Cell Biol Int 25: 33-42, 2001. (Pubitemid 32113485)
11. Sanchez-Margalet V and Najib S: Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling. Mol Cell Endocrinol 183: 113-121, 2001. (Pubitemid 32938517)
12. Huang KT, Chen YH and Walker AM: Inaccuracies in MTS assays: major distorting effects of medium, serum albumin, and fatty acids. Biotechniques 37: 406-412, 2004. (Pubitemid 39180914)
13. Simeoni L, Smida M, Posevitz V, Schraven B and Lindquist JA: Right time, right place: the organization of membrane proximal signaling. Semin Immunol 17: 35-49, 2005. (Pubitemid 39575980)
14. Cloutier JF, Chow LM and Veillette A: Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T lymphocytes. Mol Cell Biol 15: 5937-5944, 1995.
15. Itoh K, Sakakibara M, Yamasaki S, Takeuchi A, Arase H, Miyazaki M, Nakajima N, Okada M and Saito T: Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. J Immunol 168: 541-544, 2002. (Pubitemid 34049551)
16. Harder T and Simons K: Clusters of glycolipid and glycosylphosph atidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur J Immunol 29: 556-562, 1999. (Pubitemid 29078516)
17. Condeelis JS, Wyckoff JB, Bailly M, Pestell R, Lawrence D, Backer J and Segall JE: Lamellipodia in invasion. Semin Cancer Biol 11: 119-128, 2001. (Pubitemid 32423287)