A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens

Supportive Care in Cancer

Volumn 20, Issue 5, 2012, Pages 933-939

  Kashiwazaki, Haruhiko ^a   Matsushita, Takae ^a   Sugita, Junichi ^b   Shigematsu, Akio ^b   Kasashi, Kumiko ^b   Yamazaki, Yutaka ^a   Kanehira, Takashi ^a   Kondo, Takeshi ^b   Endo, Tomoyuki ^b   Tanaka, Junji ^b   Hashino, Satoshi ^b   Nishio, Mitsufumi ^b   Imamura, Masahiro ^b   Kitagawa, Yoshimasa ^a   Inoue, Nobuo ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Hematopoietic stem cell transplantation; Oral mucositis; Reduced intensity regimens

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; ETOPOSIDE; FLUDARABINE; MELPHALAN; METHOTREXATE; NARCOTIC ANALGESIC AGENT; TACROLIMUS;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGE; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CONVENTIONAL STEM CELL TRANSPLANTATION; DISEASE DURATION; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; INCIDENCE; INTERMETHOD COMPARISON; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MOUTH PAIN; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NEUTROPENIA; ORAL MUCOSITIS; PRIORITY JOURNAL; REDUCED INTENSITY CONDITIONING; RETROSPECTIVE STUDY; REVIEW; RISK FACTOR; STEM CELL TRANSPLANTATION; T CELL LEUKEMIA; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; AGE FACTORS; AGED; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STOMATITIS; TIME FACTORS; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 84863441963     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-011-1164-2     Document Type: Review

References (19)

1. Takahashi K, Soga Y, Murayama Y, Udagawa M, Nishimoto H, Sugiura Y, Maeda Y, Tanimoto M, Takashiba S (2010) Oral mucositis in patients receiving reduced-intensity regimens for allogeneic hematopoietic cell transplantation: comparison with conventional regimen. Support Care Canc 18:115-119
2. Vokurka S, Steinerova K, Karas M, Koza V (2009) Characteristics and risk factors of oral mucositis after allogeneic stem cell transplantation with FLU/MEL conditioning regimen in context with BU/CY2. Bone Marrow Transplant 44:601-605
3. Langner S, Staber P, Schub N, Gramatzki M, Grothe W, Behre G et al (2008) Palifermin reduces incidence and severity of oral mucositis in allogeneic stem-cell transplant recipients. Bone Marrow Transplant 42:275-279
4. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer- Jensen M et al (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100:1995-2025
5. Sonis ST, Oster G, Fuchs H, Bellm L, Bradford WZ, Edelsberg J et al (2001) Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol 19:2201-2005
6. Giralt S, Estey E, Albitar M et al (1997) Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy. Blood 89:4531-4536
7. Slavin S, Nagler A, Naparstek E et al (1998) Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 91:756-763
8. Mohty M, Faucher C, Vey N et al (2000) High rate of secondary viral and bacterial infections in patients undergoing allogeneic bone marrow mini-transplantation. Bone Marrow Transplant 26:251-255
9. Mohty M, Jacot W, Faucher C et al (2003) Infectious complications following allogeneic HLA-identical sibling transplantation with antithymocyte globulin-based reduced intensity preparative regimen. Leukemia 17:2168-2177
10. Toubai T, Tanaka J, Mori A et al (2004) Efficacy of etoposide, cyclophosphamide, and total body irradiation in allogeneic bone marrow transplantation for adult patients with hematological malignancies. Clin Transplant 18:552-557
11. Shigematsu A, Yamamoto S, Sugita J, Kondo T et al (2010) Increased risk of bacterial infection after engraftment in patients treated with allogeneic bone marrow transplantation following reduced-intensity conditioning regimen. Transpl Infect Dis 12 (5):412-420
12. Shigematsu A, Kondo T, Yamamoto S et al (2008) Excellent outcome of allogeneic hematopoietic stem cell transplantation using a conditioning regimen with medium-dose VP-16, cyclophosphamide and total-body irradiation for adult patients with acute lymphoblastic leukemia. Biol Blood Marrow Transplant 14:568-575
13. U.S. National Cancer Institute Common Terminology Criteria for Adverse Events v3-0 (CTCAE).
14. Gori E, Arpinati M, Bonifazi F, Errico A, Mega A, Alberani F et al (2007) Cryotherapy in the prevention of oral mucositis in patients receiving low-dose methotrexate following myeloablative allogeneic stem cell transplantation: a prospective randomized study of the Gruppo Italiano Trapianto di Midollo Osseo nurses group. Bone Marrow Transplant 39:347-352
15. Robien K, Schubert M, Bruemmer B, Lloid M, Potter J, Ulrich C (2004) Predictors of oral mucositis in patients receiving hematopoietic cell transplants for chronic myelogenous leukemia. J Clin Oncol 22:1268
16. Junghanss C, Marr KA, Carter RA et al (2002) Incidence and outcome of bacterial and fungal infections following nonmyeloablative compared with myeloablative allogeneic hematopoietic stem cell transplantation: a matched control study. Biol Blood Marrow Transplant 8:512-525
17. Hori A, Kami M, Kim SW et al (2004) Development of early neutropenic fever, with or without bacterial infection, is still a significant complication after reduced-intensity stem cell transplantation. Biol Blood Marrow Transplant 10:65-72
18. Vagliano L, Feraut C et al. (2011) Incidence and severity of oral mucositis in patients undergoing haematopoietic SCT (HSCT)- results of a multicentre study. Bone Marrow Transplant (in press)
19. Sonis ST (1998) Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol 34:39-43