The use of adipose tissue-derived stem cells within a dermal substitute improves skin regeneration by increasing neoangiogenesis and collagen synthesis

Plastic and Reconstructive Surgery

Volumn 130, Issue 1, 2012, Pages 53-63

  Meruane, Manuel A ^a,b   Rojas, Mariana ^a,b   Marcelain, Katherine ^a,b  

^a UNIVERSITY OF CHILE   (Chile)

^b Tabancura Clinic   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN;

ADIPOSE TISSUE; ANGIOGENESIS; ANIMAL; ARTICLE; BIOSYNTHESIS; COMPARATIVE STUDY; CYTOLOGY; DERMIS; DISEASE MODEL; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; INJURY; MALE; METHODOLOGY; PHYSIOLOGY; RAT; REGENERATION; SKIN; SPRAGUE DAWLEY RAT; STEM CELL TRANSPLANTATION; TRANSPLANTATION; WOUND HEALING;

ADIPOSE TISSUE; ANIMALS; COLLAGEN; DERMIS; DISEASE MODELS, ANIMAL; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; SKIN; SKIN PHYSIOLOGICAL PROCESSES; STEM CELL TRANSPLANTATION; WOUND HEALING; WOUNDS AND INJURIES;

EID: 84863432521     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/PRS.0b013e3182547e04     Document Type: Article

References (23)

1. Shevchenko RV, James SL, James SE. A review of tissueengineered skin bioconstructs available for skin reconstruction. J R Soc Interface 2010;7:229-258.
2. Burke JF, Yannas IV, Quinby WC Jr, Bondoc CC, Junk WK. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg. 1981;194: 413-428.
3. Komorowska-Timek E, Gabriel A, Bennett DC, et al. Artificial dermis as an alternative for coverage of complex scalp defects following excision of malignant tumors. Plast Reconstr Surg. 2005;115:1010-1017.
4. Jeng JC, Fidler PE, Sokolich JC, et al. Seven years' experience with Integra as a reconstructive tool. J Burn Care Res. 2007; 28:120-126.
5. Liu S, Zhang H, Zhang X, et al. Synergistic angiogenesis promoting effects of extracellular matrix scaffolds and adipose-derived stem cells during wound repair. Tissue Eng Part A 2011;17:725-739.
6. Altman A, Matthias N, Yan Y, et al. Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells. Biomaterials 2008;29:1431-1442.
7. Altman AM, Yan Y, Matthias N, et al. IFATS collection: Human adipose derived stem cells seeded on a silk fibroinchitosan scaffold enhance wound repair in a murine soft tissue injury model. Stem Cells 2009;27:250-258.
8. Orbay H, Takami Y, Hyakusoku H, Mizumo H. Acellular dermal matrix seeded with adipose-derived stem cells as a subcutaneous implant. Aesthetic Plast Surg. 2011;35:756-763.
9. Junqueira LC, Bignolas G, Bretani RR. Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J. 1979;11:447-455.
10. Young HE, Mancini ML, Wright RP, et al. Mesenchymal stem cells reside within the connective tissues of many organs. Dev Dyn. 1995;202:137-144.
11. Zuk PA, Zhu M, Mizumo H, et al. Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng. 2001;7:211-228.
12. Meruane M, Rojas M. Adipose tissue derived stem cells. Int J Morphol. 2010;28:879-889.
13. Nie C, Yang D, Morris SF. Local delivery of adipose-derived stem cells via acellular matrix as a scaffold: A new promising strategy to accelerate wound healing. Med Hypotheses 2009; 72:679-682.
14. Nambu M, Kishimoto S, Nakamura S, et al. Accelerated wound healing in healing-impaired db/db mice by autologous adipose tissue-derived stromal cells combined with atelocollagen matrix. Ann Plast Surg. 2009;62:317-321.
15. Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004;109:1292-1298.
16. Miranville A, Heeschen C, Sengenès C, Curat CA, Busse R, Bouloumié A. Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. Circulation 2004; 110:349-355.
17. Wang M, Crisostomo PR, Herring C, Meldrum KK, Meldrum DR. Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF and IGF-1 in response to TNF by a p38 MAPK-dependent mechanism. Am J Physiol Regul Integr Comp Physiol. 2006;291:R880-R884.
18. Lu F, Mizuno H, Uysal CA, Cai X, Ogawa R, Hyakusoku H. Improved viability of random pattern skin flaps through the use of adipose-derived stem cells. Plast Reconstr Surg. 2008; 121:50-58.
19. Egaña J, Danner S, Kremer M, et al. The use of glandularderived stem cells to improve vascularization in scaffold-mediated dermal regeneration. Biomaterials 2009;30:5918-5926.
20. Salem H, Ciba P, Rapoport D, et al. The influence of pancreas- derived stem cells on scaffold based skin regeneration. Biomaterials 2009;30:789-796.
21. Kim WS, Park BS, Sung JH, et al. Wound healing effect of adipose-derived stem cells: A critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci. 2007;48:15-24.
22. Kim WS, Park BS, Park SH, Kim HK, Sung JH. Antiwrinkle effect of adipose-derived stem cell: Activation of dermal fibroblast by secretory factors. J Dermatol Sci. 2009;53:96-102.
23. Park BS, Jang KA, Sung JH, et al. Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging. Dermatol Surg. 2008;34:1323-1326.