Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: An interventional case series

Clinical Ophthalmology

Volumn 6, Issue 1, 2012, Pages 721-726

  Comer, Grant M ^a   Stem, Maxwell S ^a   Saxe, Stephen J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Endophthalmitis; Fungal; Fusarium; Keratitis; Keratoplasty; Voriconazole

Indexed keywords

AMPHOTERICIN B DEOXYCHOLATE; DEXAMETHASONE; KETOCONAZOLE; NATAMYCIN; OFLOXACIN; PREDNISOLONE ACETATE; TOBRAMYCIN; VORICONAZOLE;

ADULT; ARTICLE; BLURRED VISION; CASE REPORT; CORNEA PERFORATION; CORNEA ULCER; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG MEGADOSE; DRUG WITHDRAWAL; EYE PAIN; EYE REDNESS; FEMALE; FUNGAL ENDOPHTHALMITIS; FUNGUS CULTURE; FUSARIOSIS; GRAFT REJECTION; HUMAN; KERATITIS; KERATOPLASTY; LENSECTOMY; MALE; SALVAGE THERAPY; VISUAL ACUITY; VITRECTOMY;

EID: 84863430540     PISSN: 11775467     EISSN: 11775483     Source Type: Journal    
DOI: 10.2147/OPTH.S31652     Document Type: Article

References (36)

1. Rosa RH Jr, Miller D, Alfonso EC. The changing spectrum of fungal keratitis in south Florida. Ophthalmology. 1994;101(6):1005-1013.
2. Keay L, Edwards K, Naduvilath T, et al. Microbial keratitis predisposing factors and morbidity. Ophthalmology. 2006;113(1):109-116.
3. Chang DC, Grant GB, O'Donnell K, et al. Multistate outbreak of Fusarium keratitis associated with use of a contact lens solution. JAMA. 2006;296(8):953-963.
4. Rosenberg KD, Flynn HW Jr, Alfonso EC, Miller D. Fusarium endophthalmitis following keratitis associated with contact lenses. Ophthalmic Surg Lasers Imaging. 2006;37(4):310-313.
5. Marangon FB, Miller D, Giaconi JA, Alfonso EC. In vitro investigation of voriconazole susceptibility for keratitis and endophthalmitis fungal pathogens. Am J Ophthalmol. 2004;137(5):820-825.
6. Pflugfelder SC, Flynn HW Jr, Zwickey TA, et al. Exogenous fungal endophthalmitis. Ophthalmology. 1988;95(1):19-30.
7. Gopinathan U, Ramakrishna T, Willcox M, et al. Enzymatic, clinical and histologic evaluation of corneal tissues in experimental fungal keratitis in rabbits. Exp Eye Res. 2001;72(4):433-442.
8. Jones BR, Jones DB, Lim AS, Bron AJ, Morgan G, Clayton YM. Corneal and intra-ocular infection due to Fusarium solani. Trans Ophthalmol Soc UK. 1970;89:757-779.
9. Patel AS, Hemady RK, Rodrigues M, Rajagopalan S, Elman MJ. Endogenous Fusarium endophthalmitis in a patient with acute lymphocytic leukemia. Am J Ophthalmol. 1994;117(3):363-368.
10. Dursun D, Fernandez V, Miller D, Alfonso EC. Advanced fusarium keratitis progressing to endophthalmitis. Cornea. 2003;22(4): 300-303.
11. Ferrer C, Alio J, Rodriguez A, Andreu M, Colom F. Endophthalmitis caused by Fusarium proliferatum. J Clin Microbiol. 2005;43(10): 5372-5375.
12. Rezai KA, Eliott D, Plous O, Vazquez JA, Abrams GW. Disseminated Fusarium infection presenting as bilateral endogenous endophthalmitis in a patient with acute myeloid leukemia. Arch Ophthalmol. 2005; 123(5):702-703.
13. Weissgold DJ, Orlin SE, Sulewski ME, Frayer WC, Eagle RC Jr. Delayed-onset fungal keratitis after endophthalmitis. Ophthalmology. 1998;105(2):258-262.
14. Proenca-Pina J, Ssi Yan Kai I, Bourcier T, Fabre M, Offret H, Labetoulle M. Fusarium keratitis and endophthalmitis associated with lens contact wear. Int Ophthalmol. 2010;30(1):103-107.
15. Tu EY, McCartney DL, Beatty RF, Springer KL, Levy J, Edward D. Successful treatment of resistant ocular fusariosis with posaconazole (SCH-56592). Am J Ophthalmol. 2007;143(2):222-227.
16. Bell NP, Karp CL, Alfonso EC, Schiffman J, Miller D. Effects of methylprednisolone and cyclosporine A on fungal growth in vitro. Cornea. 1999;18(3):306-313.
17. O'Day DM, Ray WA, Head WS, Robinson RD, Williams TE. Influence of corticosteroid on experimentally induced keratomycosis. Arch Ophthalmol. 1991;109(11):1601-1604.
18. Wong TY, Au Eong KG, Chan WK, Tseng PS. Fusarium keratitis following the use of topical antibiotic-corticosteroid therapy in traumatised eyes. Ann Acad Med Singapore. 1996;25(6):862-865.
19. Perry HD, Doshi SJ, Donnenfeld ED, Bai GS. Topical cyclosporin A in the management of therapeutic keratoplasty for mycotic keratitis. Cornea. 2002;21(2):161-163.
20. Rowsey JJ, Acers TE, Smith DL, Mohr JA, Newsom DL, Rodriguez J. Fusarium oxysporum endophthalmitis. Arch Ophthalmol. 1979;97(1): 103-105.
21. Goldblum D, Frueh BE, Zimmerli S, Böhnke M. Treatment of postkeratitis fusarium endophthalmitis with amphotericin B lipid complex. Cornea. 2000;19(6):853-856.
22. Reis A, Sundmacher R, Tintelnot K, Agostini H, Jensen HE, Althaus C. Successful treatment of ocular invasive mould infection (fusariosis) with the new antifungal agent voriconazole. Br J Ophthalmol. 2000; 84(8):932-933.
23. Breit SM, Hariprasad SM, Mieler WF, Shah GK, Mills MD, Grand MG. Management of endogenous fungal endophthalmitis with voriconazole and caspofungin. Am J Ophthalmol. 2005;139(1):135-140.
24. Shen YC, Wang CY, Tsai HY, Lee HN. Intracameral voriconazole injection in the treatment of fungal endophthalmitis resulting from keratitis. Am J Ophthalmol. 2010;149(6):916-921.
25. Durand ML, Kim IK, D'Amico DJ, et al. Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin. Am J Ophthalmol. 2005;140(3):552-554.
26. Klepser ME, Malone D, Lewis RE, Ernst EJ, Pfaller MA. Evaluation of voriconazole pharmacodynamics using time-kill methodology. Antimicrob Agents Chemother. 2000;44:1917-1920.
27. Hariprasad SM, Mieler WF, Holz ER, et al. Determination of vitreous, aqueous, and plasma concentration of orally administered voriconazole in humans. Arch Ophthalmol. 2004;122(1):42-47.
28. Hariprasad SM, Mieler WF, Lin TK, Sponsel WE, Graybill JR. Voriconazole in the treatment of fungal eye infections: a review of current literature. Br J Ophthalmol. Jul 2008;92(7):871-878.
29. Scott IU, Cruz-Villegas V, Flynn HW Jr, Miller D. Delayed-onset, bleb-associated endophthalmitis caused by Lecythophora mutabilis. Am J Ophthalmol. 2004;137(3):583-585.
30. Nehemy MB, Vasconcelos-Santos DV, Torqueti-Costa L, Magalhaes EP. Chronic endophthalmitis due to verticillum species after cataract surgery treated (or managed) with pars plana vitrectomy and oral and intravitreal voriconazole. Retina. 2006;26(2):225-227.
31. Sen P, Gopal L, Sen PR. Intravitreal voriconazole for drug-resistant fungal endophthalmitis: case series. Retina. 2006;26(8):935-939.
32. Kramer M, Kramer MR, Blau H, Bishara J, Axer-Siegel R, Weinberger D. Intravitreal voriconazole for the treatment of endogenous Aspergillus endophthalmitis. Ophthalmology. 2006;113(7):1184-1186.
33. Gao H, Pennesi ME, Shah K, et al. Intravitreal voriconazole: an electroretinographic and histopathologic study. Arch Ophthalmol. 2004; 122(11):130.
34. Shen Y-C, Wang M-Y, Wang CY, et al. Clearance of intravitreal voriconazole. Invest Ophthalmol Vis Sci. 2007;48:2238-2241.
35. Doft BH, Weiskopf J, Nilsson-Ehle I, Winquard LB Jr. Amphotericin clearance in vitrectomized versus nonvitrectomized eyes. Ophthalmology. 1985;92:1601-1605.
36. Vemulakonda GA, Hariprasad SM, Mieler WF, Prince RA, Shah GK, VanGelder RN. Aqueous and vitreous concentrations following topical administration of 1% voriconazole in humans. Arch Ophthalmol. 2008; 126(1):18-22.