Editorial: Is histamine the missing link in chronic inflammation?

Journal of Leukocyte Biology

Volumn 92, Issue 1, 2012, Pages 4-6

  Tiligada, Ekaterini ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Chemotaxis; Histamine receptors; Immune cells; Immunomodulation; Skin; T cell polarization

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; HISTAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; HISTAMINE H4 RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 27; MESSENGER RNA;

ALLERGY; CELL INFILTRATION; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CHRONIC INFLAMMATION; DEGRANULATION; DOWN REGULATION; ECZEMA; EDITORIAL; ERYTHEMA; GASTROINTESTINAL DISEASE; HOMEOSTASIS; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IMMUNOREGULATION; KERATINOCYTE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PRURITUS; PSORIASIS; REGULATORY T LYMPHOCYTE; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SKIN INFLAMMATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; HISTAMINE; HISTAMINE AGONISTS; HUMANS; INTERLEUKINS; RECEPTORS, HISTAMINE;

EID: 84863430461     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0212093     Document Type: Editorial

References (11)

1. Tiligada, E., Zampeli, E., Sander, K., Stark, H. (2009) Histamine H3 and H4 receptors as novel drug targets. Expert Opin. Investig. Drugs 18, 1519-1531.
2. Zampeli, E., Tiligada, E. (2009) The role of histamine H4 receptor in immune and inflammatory disorders. Br. J. Pharmacol. 157, 24-33.
3. Gschwandtner, M., Bunk, H., Köther, B., Thurmond, R. L., Kietzmann, M., Werfel, T., Bäumer, W., Gutzmer, R. (2012) Histamine down-regulates IL-27 production in antigen presenting cells. J. Leukoc. Biol. 92, 21-29.
4. O'Mahony, L., Akdis, M., Akdis, C. A. (2011) Regulation of the immune response and inflammation by histamine and histamine receptors. J. Allergy Clin. Immunol. 128, 1153-1162.
5. Alonso, M. N., Wong, M. T., Zhang, A. L., Winer, D., Suhoski, M. M., Tolentino, L. L., Gaitan, J., Davidson, M. G., Kung, T. H., Galel, D. M., Nadeau, K. C., Kim, J., Utz, P. J., Söderström, K., Engleman, E.G. (2011) TH1, TH2, and TH17 cells instruct monocytes to differentiate into specialized dendritic cell subsets. Blood 118, 3311-3320.
6. Gutzmer, R., Gschwandtner, M., Rossbach, K., Mommert, S., Werfel, T., Kietzmann, M., Baeumer, W. (2011) Pathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus. Front. Biosci. 3, 985-994.
7. Dijkstra, D., Leurs, R., Chazot, P., Shenton, F. C., Stark, H., Werfel, T., Gutzmer, R. (2007) Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. J. Allergy Clin. Immunol. 120, 300-307.
8. Fujimoto, S., Komine, M., Karakawa, M., Uratsuji, H., Kagami, S., Tada, Y., Saeki, H., Ohtsuki, M., Tamaki, K. (2011) Histamine differentially regulates the production of Th1 and Th2 chemokines by keratinocytes through histamine H1 receptor. Cytokine 54, 191-199.
9. Rosethorne, E. M., Charlton, S. J. (2011) Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits _-arrestin without activating G proteins. Mol. Pharmacol. 79, 749-757.
10. Kyriakidis, D. A., Theodorou, M. C., Tiligada, E. (2012) Histamine in two component system-mediated bacterial signaling. Front. Biosci. 17, 1108-1119.
11. Zampeli, E., Thurmond, R. L., Tiligada, E. (2009) The histamine H4 receptor antagonist JNJ7777120 induces increases in the histamine content of the rat conjunctiva. Inflamm. Res. 58, 285-291.