Cysteinyl-tRNA deacylation can be uncoupled from protein synthesis

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  David, Alexandre ^a   Das, Suman R ^a   Gibbs, James S ^a   Bennink, Jack R ^a   Yewdell, Jonathan W ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOACYL TRANSFER RNA; CYSTEINE TRANSFER RNA; LEUCINE TRANSFER RNA; LYSINE TRANSFER RNA; METHIONINE TRANSFER RNA; SERINE TRANSFER RNA; AMINO ACID TRANSFER RNA LIGASE; ARSENIC TRIOXIDE; ARSENOUS ACID DERIVATIVE; CYSTEINE;

ARTICLE; CELL MIGRATION; CELL SPECIFICITY; COMPLEX FORMATION; CONTROLLED STUDY; DEACYLATION; HELA CELL; INTERMETHOD COMPARISON; ISOTOPE LABELING; MOLECULAR INTERACTION; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN SYNTHESIS; TRANSLATION INITIATION; TRANSLATION REGULATION; ACYLATION; DRUG EFFECT; FLUORESCENCE MICROSCOPY; HUMAN; METABOLISM; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS;

ACYLATION; AMINO ACYL-TRNA SYNTHETASES; ARSENITES; CYSTEINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HELA CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; PROTEIN BIOSYNTHESIS; RNA, TRANSFER, CYS;

EID: 84863407818     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033072     Document Type: Article

References (20)

1. Netzer N, Goodenbour JM, David A, Dittmar KA, Jones RB, et al. (2009) Innate immune and chemically triggered oxidative stress modifies translational fidelity. Nature 462: 522-526.
2. Jones TE, Alexander RW, Pan T, (2011) Misacylation of specific nonmethionyl tRNAs by a bacterial methionyl-tRNA synthetase. Proc Natl Acad Sci U S A 108: 6933-6938.
3. Schimmel P, Ribas de Pouplana L, (2001) Formation of two classes of tRNA synthetases in relation to editing functions and genetic code. Cold Spring Harb Symp Quant Biol 66: 161-166.
4. David A, Netzer N, Strader MB, Das SR, Chen CY, et al. (2011) RNA-binding targets aminoacyl-tRNA-synthetases to translating ribosomes. J Biol Chem.
5. Stapulionis R, Deutscher MP, (1995) A channeled tRNA cycle during mammalian protein synthesis. Proc Natl Acad Sci U S A 92: 7158-7161.
6. Stephens SB, Dodd RD, Brewer JW, Lager PJ, Keene JD, et al. (2005) Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation. Mol Biol Cell 16: 5819-5831.
7. Kappen LS, Suzuki H, Goldberg IH, (1973) Inhibition of reticulocyte peptide-chain initiation by pactamycin: accumulation of inactive ribosomal initiation complexes. Proc Natl Acad Sci U S A 70: 22-26.
8. Kedersha N, Anderson P, (2002) Stress granules: sites of mRNA triage that regulate mRNA stability and translatability. Biochem Soc Trans 30: 963-969.
9. Chen LC, Casadevall A, (1999) Labeling of proteins with [35S]methionine and/or [35S]cysteine in the absence of cells. Anal Biochem 269: 179-188.
10. Quevillon S, Robinson JC, Berthonneau E, Siatecka M, Mirande M, (1999) Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. J Mol Biol 285: 183-195.
11. Aspen AJ, Hoagland MB, (1978) Uncoupling of amino acid turnover on transfer RNA from protein synthesis in HeLa cells. Biochim Biophys Acta 518: 482-496.
12. Stephens SB, Nicchitta CV, (2008) Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. Mol Biol Cell 19: 623-632.
13. Eldred EW, Schimmel PR, (1972) Rapid deacylation by isoleucyl transfer ribonucleic acid synthetase of isoleucine-specific transfer ribonucleic acid aminoacylated with valine. J Biol Chem 247: 2961-2964.
14. Schreier AA, Schimmel PR, (1972) Transfer ribonucleic acid synthetase catalyzed deacylation of aminoacyl transfer ribonucleic acid in the absence of adenosine monophosphate and pyrophosphate. Biochemistry 11: 1582-1589.
15. Ruan B, Soll D, (2005) The bacterial YbaK protein is a Cys-tRNAPro and Cys-tRNA Cys deacylase. J Biol Chem 280: 25887-25891.
16. Chen W, Yewdell JW, Levine RL, Bennink JR, (1999) Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants. Journal of Experimental Medicine 189: 1757-1764.
17. Meadows L, Wang W, den Haan JMM, Blokland E, Reinhardus C, et al. (1997) The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. Immunity 6: 273-281.
18. Staschke KA, Dey S, Zaborske JM, Palam LR, McClintick JN, et al. (2010) Integration of General Amino Acid Control and Target of Rapamycin (TOR) Regulatory Pathways in Nitrogen Assimilation in Yeast. Journal of Biological Chemistry 285: 16893-16911.
19. Lerner RS, Nicchitta CV, (2006) mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation. Rna 12: 775-789.
20. Varshney U, Lee CP, RajBhandary UL, (1991) Direct analysis of aminoacylation levels of tRNAs in vivo. Application to studying recognition of Escherichia coli initiator tRNA mutants by glutaminyl-tRNA synthetase. J Biol Chem 266: 24712-24718.