LC-MS/MS characterization of phospholipid content in daptomycin-susceptible and-resistant isolates of Staphylococcus aureus with mutations in mprF

Molecular Membrane Biology

Volumn 29, Issue 1, 2012, Pages 1-8

  Rubio, Aileen ^a   Moore, Jeff ^b   Varoglu, Mustafa ^a   Conrad, Mary ^a   Chu, Min ^a   Shaw, Walter ^b   Silverman, Jared A ^a  

^a CUBIST PHARMACEUTICALS INC   (United States)

^b Avanti Polar Lipids   (United States)

Author keywords

Daptomycin; Lysylphosphatidylglycerol; MprF; S. aureus resistance

Indexed keywords

DAPTOMYCIN; PHOSPHATIDYLGLYCEROL; PHOSPHOLIPID; SYNTHETASE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; BIOASSAY; CELL MEMBRANE; CYTOPLASM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SENSITIVITY ANALYSIS; STAPHYLOCOCCUS AUREUS;

AMINOACYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CHROMATOGRAPHY, LIQUID; DAPTOMYCIN; IONS; LYSINE; MICROBIAL SENSITIVITY TESTS; MUTATION; PHOSPHATIDYLGLYCEROLS; PHOSPHOLIPIDS; STAPHYLOCOCCUS AUREUS; TANDEM MASS SPECTROMETRY;

STAPHYLOCOCCUS AUREUS;

EID: 84863402669     PISSN: 09687688     EISSN: 14645203     Source Type: Journal    
DOI: 10.3109/09687688.2011.640948     Document Type: Article

References (17)

1. Arnaud M, Chastanet A, Debarbouille M. 2004. New vector for efficient allelic replacement in naturally nontransformable, low-GC-content, gram-positive bacteria. Appl Environ Microbiol 70:6887-6891. (Pubitemid 39518603)
2. Bligh EG, Dyer WJ. 1959. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917.
3. Chan HLY, Leung NWY, Hui AY, Wong VWS, Liew CT, Chim AML, Chan FKL, Hung LCT, Lee YT, Tam JSL, Lam CWKL, Sung JJY. 2005. A randomized, controlled trial of combination therapy for chronic hepatitis B: Comparing pegylated interferon-alpha2b and lamivudine with lamivudine alone. Ann Intern Med 142:240-250. (Pubitemid 40216241)
4. Chen PS, Toribara TY, Warner H. 1956. Microdetermination of phosphorus. Ann Chem 28:1756-1758.
5. Enoch DA, Bygott JM, Daly ML, Karas JA. 2007. Daptomycin. J Infect 55:205-213. (Pubitemid 47248484)
6. Ernst CM, Staubitz P, Mishra NN, Yang SJ, Hornig G, Kalbacher H, Bayer AS, Kraus D, Peschel A. 2009. The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion. PLoS Pathog 5:e1000660.
7. Fiske CH, Subbarow Y. 1925. The colorimetric determination of phosphorus. J Biol Chem 66:375-400.
8. Friedman L, Alder JD, Silverman JA. 2006. Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus. Antimicrob Agents Chemother 50:2137-2145. (Pubitemid 43807536)
9. Jones T, Yeaman MR, Sakoulas G, Yang SJ, Proctor RA, Sahl HG, Schrenzel J, Xiong YQ, Bayer AS. 2008. Failures in clinical treatment of Staphylococcus aureus infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding. Antimicrob Agents Chemother 52:269-278.
10. Kristian SA, Durr M, van Strijp JAG, Neumeister B, Peschel A. 2003. MprF-mediated lysinylation of phospholipids in Staphylococcus aureus leads to protection against oxygen-independent neutrophil killing. Infect Immun 71:546-549. (Pubitemid 36026063)
11. Luchansky JB, Muriana PM, Klaenhammer TR. 1988. Application of electroporation for transfer of plasmid DNA to Lactobacillus, Lactococcus, Leuconostoc, Listeria, Pediococcus, Bacillus, Staphylococcus, Enterococcus and Propionibacterium. Mol Microbiol 2:637-646.
12. Mishra NN, Yang SJ, Sawa A, Rubio A, Nast CC, Yeaman MR, Bayer AS. 2009. Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 53:2312-2318.
13. Rubio A, Conrad M, Haselbeck R, Kedar GC, Driver V, Finn J, Silverman J. 2010. Regulation of mprF by antisense restores daptomycin susceptibility to daptomycin-resistant isolates of Staphylococcus aureus. Antimicrob Agents Chemother 55:364-367.
14. Said-Salim B, Mathema B, Kreiswirth BN. 2003. Community-acquired methicillin-resistant Staphylococcus aureus: An emerging pathogen. Infect Control Hosp Epidemiol 24:451-455. (Pubitemid 36818516)
15. Silverman JA, Oliver N, Andrew T, Li T. 2001. Resistance studies with daptomycin. Antimicrob Agents Chemother 45:1799-1802. (Pubitemid 32466351)
16. Tally FP, Zeckel M, Wasilewski MM, Carini C, Berman CL, Drusano GL, Oleson FB Jr. 1999. Daptomycin: A novel agent for Gram-positive infections. Expert Opin Investig Drugs 8:1223-1238. (Pubitemid 29410579)
17. White DC, Frerman FE. 1967. Extraction, characterization, and cellular localization of the lipids of Staphylococcus aureus. J Bacteriol 94:1854-1867.