Production of active human glucocerebrosidase in seeds of Arabidopsis thaliana complex-glycan-deficient (cgl) plants

Glycobiology

Volumn 22, Issue 4, 2012, Pages 492-503

  He, Xu ^a   Galpin, Jason D ^a   Tropak, Michael B ^b   Mahuran, Don ^b,c   Haselhorst, Thomas ^d   Von Itzstein, Mark ^d   Kolarich, Daniel ^e   Packer, Nicolle H ^e   Miao, Yansong ^f   Jiang, Liwen ^f   Grabowski, Gregory A ^g   Clarke, Lorne A ^h   Kermode, Allison R ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d GRIFFITH UNIVERSITY   (Australia)

^e MACQUARIE UNIVERSITY   (Australia)

^f CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^g UNIVERSITY OF CINCINNATI   (United States)

^h UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Arabidopsis cgl mutant; Gaucher disease; human glucocerebrosidase; mannose terminated N glycans; N glycosylation

Indexed keywords

AMINO ACID DERIVATIVE; CHAPERONE; FUCOSE; GLUCOSYLCERAMIDASE; GLYCAN; IMIGLUCERASE; ISOFAGOMINE; MANNOSE; N ACETYLGLUCOSAMINYLTRANSFERASE; N ACETYLGLUCOSAMINYLTRANSFERASE I; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; XYLOSE;

ANIMAL CELL; APOPLAST; ARABIDOPSIS; ARTICLE; DRUG MANUFACTURE; ENZYME KINETICS; ENZYME PURIFICATION; GENE CASSETTE; GENE EXPRESSION; GENE MUTATION; MACROPHAGE; MOUSE; NONHUMAN; PLANT PARENCHYMA CELL; PLANT SEED; PRIORITY JOURNAL; SEED STORAGE; STRUCTURE ANALYSIS; THERMOSTABILITY;

ANIMALS; ARABIDOPSIS; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; CELLS, CULTURED; ENZYME STABILITY; GLUCOSYLCERAMIDASE; GLYCOSYLATION; HUMANS; KINETICS; MACROPHAGES; MANNOSE; MICE; MOLECULAR SEQUENCE DATA; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; SEEDS;

ARABIDOPSIS; ARABIDOPSIS THALIANA;

EID: 84863398445     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwr157     Document Type: Article

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