Prolonged remission after long-term treatment with steroidogenesis inhibitors in Cushing's syndrome caused by ectopic ACTH secretion

European Journal of Endocrinology

Volumn 166, Issue 3, 2012, Pages 531-536

  Sharma, S T ^a   Nieman, L K ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; CYPROHEPTADINE; DEXAMETHASONE; HYDROCORTISONE; KETOCONAZOLE; METYRAPONE; MITOTANE;

ACTH SECRETING ADENOMA; ADRENAL CORTEX ATROPHY; ADRENAL HYPERPLASIA; ADRENAL INSUFFICIENCY; ADRENALECTOMY; ADULT; ARTICLE; BIOCHEMISTRY; CASE REPORT; CHRONIC DRUG ADMINISTRATION; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CUSHING SYNDROME; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFECT; DRUG WITHDRAWAL; ECTOPIC CORTICOTROPIN PRODUCTION; FEMALE; HUMAN; HYDROCORTISONE URINE LEVEL; HYPERCORTISOLISM; LOW DRUG DOSE; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RECURRENT DISEASE; REMISSION; SIDE EFFECT; STEROIDOGENESIS; TRANSSPHENOIDAL HYPOPHYSECTOMY;

ACTH SYNDROME, ECTOPIC; ADULT; CUSHING SYNDROME; FEMALE; HORMONE ANTAGONISTS; HUMANS; MALE; MIDDLE AGED; REMISSION INDUCTION; STEROIDS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84863394127     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-11-0949     Document Type: Article

References (21)

1. Ishibashi M, Shimada K, Abe K, Furue H & Yamaji T. Spontaneous remission in Cushing's disease. Archives of Internal Medicine 1993 153 251-255. (doi:10.1001/archinte.1993.00410020097009)
2. Dickstein G, Spindel A, Shechner C, Adawi F & Gutman H. Spontaneous remission in Cushing's disease. Archives of Internal Medicine 1991 151 185-189. (doi:10.1001/archinte.1991.00400010171028)
3. Taylor HC, McLean S & Monheim K. Resolution of Cushing's disease followed by secondary adrenal insufficiency after anticoagulant-associated pituitary hemorrhage: report of a case and review of the literature. Endocrine Practice 2003 9 147-151.
4. Pignatta AB, Diaz AG, Gomez R & Bruno OD. Spontaneous remission of Cushing's disease after disappearance of a micro-adenoma attached to the pituitary stalk. Pituitary 2004 7 45-49. (doi:10.1023/B:PITU.0000044626.25624. 48)
5. Meinardi JR, Wolffenbuttel BH & Dullaart RP. Cyclic Cushing's syndrome: a clinical challenge. European Journal of Endocrinology 2007 157 245-254. (doi:10.1530/EJE-07-0262)
6. Alexandraki K, Kaltas GA, Isidori AM, Akker SA, Drake WM, Chew SL, Monson JP, Besser GM & Grossman AB. The prevalence and characteristic features of cyclicity and variability in Cushing's disease. European Journal of Endocrinology 2009 160 1011-1018. (doi:10.1530/EJE-09-0046)
7. Beardwell CG, Adamson AR & Shalet SM. Prolonged remission in florid Cushing's syndrome following metyrapone treatment. Clinical Endocrinology 1981 14 485-492. (doi:10.1111/j.1365-2265.1981.tb00638.x)
8. Loh KC, Gupta R & Schlossberg AH. Spontaneous remission of ectopic Cushing's syndrome due to pheochromocytoma: a case report. European Journal of Endocrinology 1996 135 440-443. (doi:10.1530/eje.0.1350440)
9. Zemskova MS, Gundabolu B, Sinaii N, Chen CC, Carrasquilo JA, Whatley M, Chowdhary I, Gharib AM & Nieman LK. Utility of various functional and anatomic imaging modalities for detection of ectopic adrenocorticotropin- secreting tumors. Journal of Clinical Endocrinology and Metabolism 2010 95 1207-1219. (doi:10.1210/jc.2009-2282)
10. Nieman LK. Medical therapy of Cushing's disease. Pituitary 2002 5 77-82. (doi:10.1023/A:1022308429992)
11. Hutter AM & Kayhoe DE. Adrenal cortical carcinoma: results of treatment with o,p'-DDD in 138 patients. American Journal of Medicine 1966 41 581-592. (doi:10.1016/0002-9343(66) 90220-8)
12. Mizoguchi Y, Kajiume T, Miyagawa S, Okada S, Nichi Y &Kobayashi M. Steroid-dependent ACTH-produced thymic carcinoid: regulation of POMC gene expression by cortisol via methylation of its promoter region. Hormone Research 2007 67 257-262. (doi:10.1159/000098548)
13. Steen RE, Kapelrud H, Haug E & Frey H. In vivo and in vitro inhibition by ketoconazole of ACTH secretion from a human thymic carcinoid tumour. Acta Endocrinologica 1991 125 331-334.
14. Coates PJH, Doniach I, Howlett TA, Rees LH & Besser GM. An immunocytochemical study of 18 tumours causing ectopic Cushing's syndrome. Journal of Clinical Pathology 1986 39 955-960. (doi:10.1136/jcp.39.9.955)
15. Oliver RL, Davis JR & White A. Characterization of ACTH related peptides in ectopic Cushing's syndrome. Pituitary 2003 6 119-126. (doi:10.1023/B:PITU.0000011172.26649.df)
16. de Keyzer Y, Bertagna X, Lenne F, Girard F, Luton JP & Kahn A. Altered proopiomelanocortin gene expression in adrenocorticotropin- producing nonpituitary tumors. Journal of Clinical Investigation 1985 76 1892-1898. (doi:10.1172/JCI112184)
17. Newell-Price J. Proopiomelanocortin gene expression and DNA methylation: implications for Cushing's syndrome and beyond. Journal of Endocrinology 2003 177 365-372. (doi:10.1677/joe.0.1770365)
18. Kreiger DT, Amorosa L & Linick F. Cyproheptadine-induced remission of Cushing's disease. New England Journal of Medicine 1975 293 893-896. (doi:10.1056/NEJM197510302931802)
19. Barnes P, Shaw K & Ross E. Cushing's disease: successful treatment with cyproheptadine. Lancet 1977 1 1148-1149. (doi:10.1016/S0140-6736(77)92402- 3)
20. Schteingart DE. Drugs in the medical treatment of Cushing's syndrome. Expert Opinion on Emerging Drugs 2009 14 661-671. (doi:10.1517/ 14728210903413522)
21. Kamenicky P, Droumaguet C, Salenave S, Blanchard A, Jublanc C, Gautieer JF, Brailly-Tabard S, Leboulleux S, Schlumberger M, Baudin E, Chanson P & Young J. Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism 2011 96 2796-2804. (doi:10.1210/jc.2011-0536)