Acute upper airway responses to hypoglossal nerve stimulation during sleep in obstructive sleep apnea

American Journal of Respiratory and Critical Care Medicine

Volumn 185, Issue 4, 2012, Pages 420-426

  Schwartz, Alan R ^a   Barnes, Maree ^b   Hillman, David ^c   Malhotra, Atul ^d   Kezirian, Eric ^e   Smith, Philip L ^a   Hoegh, Thomas ^f   Parrish, Daniel ^f   Eastwood, Peter R ^c,g  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b AUSTIN HOSPITAL   (Australia)

^c SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f Apnex Medical   (United States)

^g UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Electrical hypoglossal nerve stimulation; Obstructive sleep apnea; Pharynx; Titration; Upper airway

Indexed keywords

ADULT; AIRFLOW; AIRWAY; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY MASS; CLINICAL ARTICLE; DEVICES; DISEASE SEVERITY; ELECTRODE; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; ELECTROOCULOGRAPHY; ELECTROSTIMULATION THERAPY; FEMALE; HUMAN; HYPOGLOSSAL NERVE; IMPLANTATION; MALE; NECK; NERVE STIMULATION; NONREM SLEEP; OBESITY; OXYGEN SATURATION; PHARYNX; PNEUMOTACHYGRAPHY; POLYSOMNOGRAPHY; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; TITRIMETRY; TONGUE; TREATMENT RESPONSE; WAIST CIRCUMFERENCE;

ELECTRIC STIMULATION THERAPY; FEMALE; HUMANS; HYPOGLOSSAL NERVE; IMPLANTABLE NEUROSTIMULATORS; INHALATION; LEAST-SQUARES ANALYSIS; MALE; MIDDLE AGED; PULMONARY VENTILATION; SLEEP APNEA, OBSTRUCTIVE; TREATMENT OUTCOME;

EID: 84863393215     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201109-1614OC     Document Type: Article

References (37)

1. Remmers JE, deGroot WJ, Sauerland EK, Anch AM. Pathogenesis of upper airway occlusion during sleep. J Appl Physiol 1978;44:931-938. (Pubitemid 9158239)
2. Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ. The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls. J Physiol 2005;564:549-562. (Pubitemid 40585053)
3. Punjabi NM, O'Hearn DJ, Neubauer DN, Nieto FJ, Schwartz AR, Smith PL, Bandeen-Roche K. Modeling hypersomnolence in sleep-disordered breathing: a novel approach using survival analysis. Am J Respir Crit Care Med 1999;159:1703-1709. (Pubitemid 29275031)
4. Kribbs NB, Pack AI, Kline LR, Getsy JE, Schuett JS, Henry JN, Maislin G, Dinges DF. Effects of one night without nasal CPAP treatment on sleep and sleepiness in patients with obstructive sleep apnea. Am Rev Respir Dis 1993;147:1162-1168. (Pubitemid 23149873)
5. Punjabi NM, Polotsky VY. Disorders of glucose metabolism in sleep apnea. J Appl Physiol 2005;99:1998-2007. (Pubitemid 41547203)
6. Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005;365:1046-1053. (Pubitemid 40386782)
7. Basner RC. Continuous positive airway pressure for obstructive sleep apnea. N Engl J Med 2007;356:1751-1758. (Pubitemid 46661544)
8. Kribbs NB, Pack AI, Kline LR, Smith PL, Schwartz AR, Schubert NM, Redline S, Henry JN, Getsy JE, Dinges DF. Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea. Am Rev Respir Dis 1993;147:887-895. (Pubitemid 23093812)
9. Weaver TE, Kribbs NB, Pack AI, Kline LR, Chugh DK, Maislin G, Smith PL, Schwartz AR, Schubert NM, Gillen KA, et al. Night-tonight variability in CPAP use over the first three months of treatment. Sleep 1997;20:278-283. (Pubitemid 27276642)
10. Ng AT, Gotsopoulos H, Qian J, Cistulli PA. Effect of oral appliance therapy on upper airway collapsibility in obstructive sleep apnea. Am J Respir Crit Care Med 2003;168:238-241. (Pubitemid 36920980)
11. Schwartz AR, Schubert N, Rothman W, Godley F, Marsh B, Eisele D, Nadeau J, Permutt L, Gleadhill I, Smith PL. Effect of uvulopalatopharyngoplasty on upper airway collapsibility in obstructive sleep apnea. Am Rev Respir Dis 1992;145:527-532.
12. Schwartz AR, Gold AR, Schubert N, Stryzak A, Wise RA, Permutt S, Smith PL. Effect of weight loss on upper airway collapsibility in obstructive sleep apnea. Am Rev Respir Dis 1991;144:494-498.
13. Schwartz AR, Bennett ML, Smith PL, De Backer W, Hedner J, Boudewyns A, Van de HP, Ejnell H, Hochban W, Knaack L, et al. Therapeutic electrical stimulation of the hypoglossal nerve in obstructive sleep apnea. Arch Otolaryngol Head Neck Surg 2001;127: 1216-1223. (Pubitemid 32947452)
14. Oliven A, Odeh M, Geitini L, Oliven R, Steinfeld U, Schwartz AR, Tov N. Effect of co-activation of tongue protrusor and retractor muscles on pharyngeal lumen and airflow in sleep apnea patients. J Appl Physiol 2007;103:1662-1668. (Pubitemid 350033851)
15. Oliven A, Tov N, Geitini L, Steinfeld U, Oliven R, Schwartz AR, Odeh M. Effect of genioglossus contraction on pharyngeal lumen and airflow in sleep apnoea patients. Eur Respir J 2007;30:748-758. (Pubitemid 351194837)
16. Oliven A, O'Hearn DJ, Boudewyns A, Odeh M, De BW, Van de HP, Smith PL, Eisele DW, Allan L, Schneider H, et al. Upper airway response to electrical stimulation of the genioglossus in obstructive sleep apnea. J Appl Physiol 2003;95:2023-2029. (Pubitemid 37310388)
17. Oliven R, Tov N, Odeh M, Gaitini L, Steinfeld U, Schwartz AR, Oliven A. Interacting effects of genioglossus stimulation and mandibular advancement in sleep apnea. J Appl Physiol 2009;106:1668-1673.
18. Schwartz AR, Eisele DW, Hari A, Testerman R, Erickson D, Smith PL. Electrical stimulation of the lingual musculature in obstructive sleep apnea. J Appl Physiol 1996;81:643-652. (Pubitemid 26303214)
19. Eisele DW, Smith PL, Alam DS, Schwartz AR. Direct hypoglossal nerve stimulation in obstructive sleep apnea. Arch Otolaryngol Head Neck Surg 1997;123:57-61. (Pubitemid 27043659)
20. Kezirian EJ, Boudewyns A, Eisele DW, Schwartz AR, Smith PL, Van de Heyning PH, De Backer WA. Electrical stimulation of the hypoglossal nerve in the treatment of obstructive sleep apnea. Sleep Med Rev 2010;14:299-305.
21. Schwartz AR, Barnes M, Hillman DR, Kezirian EJ, Smith PL, Hoegh T, Parrish D, Eastwood PR. Acute effects of hypoglossal nerve stimulation on airflow and arousal. Am J Respir Crit Care Med 2011;183:A2728.
22. Schwartz AR, Barnes M, Hillman DR, Kezirian EJ, Malhotra A, Smith PL, Hoegh T, Parrish D. Upper airway responses to hypoglossal nerve stimulation during sleep in obstructive sleep apnea. Sleep 2011;34:A118.
23. Eastwood PR, Barnes M, Walsh JH, Maddison KJ, Hee G, Schwartz AR, Smith PL, Malhotra A, McEvoy RD, Wheatley JR, et al. Treating obstructive sleep apnea with hypoglossal nerve stimulation. Sleep 2011;34:1479-1486.
24. Iber C, Ancoli-Israel S, Chesson AL, Quan SF. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, 1st ed. Westchester, IL: American Academy of Sleep Medicine; 2007.
25. Schwartz AR, Smith PL, Wise RA, Bankman I, Permutt S. Effect of positive nasal pressure on upper airway pressure-flow relationships. J Appl Physiol 1989;66:1626-1634. (Pubitemid 19112967)
26. Dawson SV, Elliott EA. Wave-speed limitation on expiratory flow: a unifying concept. J Appl Physiol 1977;43:498-515. (Pubitemid 8190226)
27. Gold AR, Schwartz AR. The pharyngeal critical pressure. The whys and hows of using nasal continuous positive airway pressure diagnostically. Chest 1996;110:1077-1088. (Pubitemid 26347629)
28. Fuller D, Mateika JH, Fregosi RF. Co-activation of tongue protrudor and retractor muscles during chemoreceptor stimulation in the rat. J Physiol 1998;507:265-276. (Pubitemid 28102691)
29. Fuller D, Williams JS, Janssen PL, Fregosi RF. Effect of co-activation of tongue protrudor and retractor muscles on tongue movements and pharyngeal airflow mechanics in the rat. J Physiol (Lond) 1999;519(Pt 2):601-613. (Pubitemid 29430021)
30. Miki H, Hida W, Chonan T, Kikuchi Y, Takishima T. Effects of submental electrical stimulation during sleep on upper airway patency in patients with obstructive sleep apnea. Am Rev Respir Dis 1989;140: 1285-1289. (Pubitemid 19276210)
31. Decker MJ, Haaga J, Arnold JL, Atzberger D, Strohl KP. Functional electrical stimulation and respiration during sleep. J Appl Physiol 1993;75:1053-1061. (Pubitemid 23289590)
32. Edmonds LC, Daniels BK, Stanson AW, Sheedy PF, Shepard JWJ. The effects of transcutaneous electrical stimulation during wakefulness and sleep in patients with obstructive sleep apnea. Am Rev Respir Dis 1992;146:1030-1036.
33. Oliven A, Schnall RP, Pillar G, Gavriely N, Odeh M. Sublingual electrical stimulation of the tongue during wakefulness and sleep. Respir Physiol 2001;127:217-226. (Pubitemid 32720507)
34. Condos R, Norman RG, Krishnasamy I, Peduzzi N, Goldring RM, Rapoport DM. Flow limitation as a noninvasive assessment of residual upper-airway resistance during continuous positive airway pressure therapy of obstructive sleep apnea. Am J Respir Crit Care Med 1994;150:475-480.
35. Hosselet JJ, Norman RG, Ayappa I, Rapoport DM. Detection of flow limitation with a nasal cannula/pressure transducer system. Am J Respir Crit Care Med 1998;157:1461-1467.
36. McGinley BM, Schwartz AR, Schneider H, Kirkness JP, Smith PL, Patil SP. Upper airway neuromuscular compensation during sleep is defective in obstructive sleep apnea. J Appl Physiol 2008;105:197-205.
37. Patil SP, Schneider H, Marx JJ, Gladmon E, Schwartz AR, Smith PL. Neuromechanical control of upper airway patency during sleep. J Appl Physiol 2007;102:547-556. (Pubitemid 46220882)