Correlation between hMLH1-93G/A gene polymorphism and colorectal cancer

Chinese Journal of Gastroenterology

Volumn 16, Issue 4, 2011, Pages 214-217

  Zhang, Lili ^a   Cao, Jun ^a   Shen, Weidong ^a   Zhu, Hao ^a   Shen, Yonghua ^a   Zou, Xiaoping ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Alleles; Colorectal neoplasms; DNA mismatch repair; Genes, hMLH1; Genotype; Polymorphism, single nucleotide

Indexed keywords

PROTEIN MLH1;

ARTICLE; CANCER STAGING; COLORECTAL CANCER; CONTROLLED STUDY; DNA POLYMORPHISM; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; LYMPH NODE METASTASIS;

EID: 84863392491     PISSN: 10087125     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1008-7125.2011.04.006     Document Type: Article

References (17)

1. de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer, 2004, 4 (10): 769-780.
2. Kunkel T A, Erie D A. DNA mismatch repair. Annu Rev Biochem, 2005, 74: 681-710.
3. 2008, 11 (5): 462-464.
4. Fengju S, Guanglin W, Kexin C. Incidence of colon cancer in Tianjin, China, 1981-2000. Asia Pac J Public Health, 2005, 17: 22-25.
5. Zheng S, Cai S R. Colorectal cancer epidemiology and prevention study in China. Chinese-German J Clin Oncol, 2003, 2 (2): 72-75.
6. Marth G, Yeh R, Minton M, et al. Single-nucleotide polymorphisms in the public domain: how useful are they? Nat Genet, 2001, 27 (4): 371-372.
7. Alexander D D, Cushing C A, Lowe K A, et al. Metaanalysis of animal fat or animal protein intake and colorectal cancer. Am J Clin Nutr, 2009, 89 (5): 1402-1409.
8. Mei Q, Yan H L, Ding F X, et al. Single-nucleotide polymorphisms of mismatch repair genes in healthy Chinese individuals and sporadic colorectal cancer patients. Cancer Genet Cytogenet, 2006, 171 (1): 17-23.
9. Ito E, Yanagisawa Y, Iwahashi Y, et al. A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1. Biochem Biophys Res Commun, 1999, 256 (3): 488-494.
10. Campbell P T, Curtin K, Ulrich C M, et al. Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors. Gut, 2009, 58 (5): 661-667.
11. Park S H, Lee G Y, Jeon H S, et al. -93G-->A polymorphism of hMLH1 and risk of primary lung cancer. Int J Cancer, 2004, 112 (4): 678-682.
12. Arita M, Zhong X, Min Z, et al. Multiple sites required for expression in 5'-flanking region of the hMLH1 gene. Gene, 2003, 306: 57-65.
13. Lee K M, Choi J Y, Kang C, et al. Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk. Clin Cancer Res, 2005, 11 (12): 4620-4626.
14. Yu J H, Bigler J, Whitton J, et al. Mismatch repair polymorphisms and colorectal polyps: hMLH1-93G >A variant modifies risk associated with smoking. Am J Gastroenterol, 2006, 101 (6): 1313-1319.
15. Mei M, Liu D, Dong S, et al. The MLH1 -93 promoter variant influences gene expression. Cancer Epidemiol, 2010, 34 (1): 93-95.
16. Brenner C, Deplus R, Didelot C, et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J, 2005, 24 (2): 336-346.
17. Brenner C, Fuks F. DNA methyltransferases: facts, clues, mysteries. Curr Top Microbiol Immunol, 2006, 301: 45-66.