Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: Results of a prospective, randomized international trial in lung transplantation

Journal of Heart and Lung Transplantation

Volumn 31, Issue 8, 2012, Pages 797-804

  Treede, Hendrik ^a   Glanville, Allan R ^b   Klepetko, Walter ^c   Aboyoun, Christina ^b   Vettorazzi, Eik ^d   Lama, Raffael ^e   Bravo, Carlos ^f   Knoop, Christiane ^g   Aubert, John David ^h   Reichenspurner, Hermann ^a  

^a UNIVERSITY HEART CENTER HAMBURG   (Germany)

^b ST VINCENT S HOSPITAL   (Australia)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^f HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^g ERASME HOSPITAL   (Belgium)

^h LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

bronchiolitis obliterans syndrome (BOS); calcineurin inhibitors; chronic rejection; immunosuppression; lung transplantation

Indexed keywords

CYCLOSPORIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; TACROLIMUS;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; BACTERIAL INFECTION; BRONCHIOLITIS OBLITERANS; CONTINUOUS INFUSION; CONTROLLED STUDY; CYTOLYSIS; CYTOPENIA; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RATE; KIDNEY FAILURE; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTICENTER STUDY; MYCOSIS; NEPHROTOXICITY; NEUROTOXICITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SURVIVAL; TREATMENT OUTCOME; VIRUS INFECTION;

ADULT; BRONCHIOLITIS OBLITERANS; CYCLOSPORINE; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INCIDENCE; INTERNATIONAL COOPERATION; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; SYNDROME; TACROLIMUS; TREATMENT OUTCOME;

EID: 84863337211     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2012.03.008     Document Type: Article

References (25)

1. J.D. Christie, L.B. Edwards, A.Y. Kucheryavaya The registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplantation report - 2010 J Heart Lung Transplant 29 2010 1104 1118
2. G.I. Snell, A. Boehler, A.R. Glanville Eleven years on: a clinical update of key areas of the 1996 lung allograft rejection working formulation J Heart Lung Transplant 26 2007 423 430
3. M. Estenne, J.R. Maurer, A. Boehler Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria J Heart Lung Transplant 21 2002 297 310
4. Toronto Lung Transplant Group Unilateral lung transplantation for pulmonary fibrosis N Engl J Med 314 1986 1140 1145
5. The U.S. Multicenter FK506 Liver Study Group A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression in liver transplantation N Engl J Med 331 1994 1110 1115
6. R.R. Hachem, R.D. Yusen, M.M. Chakinala A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation J Heart Lung Transplant 26 2007 1012 1018
7. R.J. Keenan, H. Konishi, A. Kawai Clinical trial of tacrolimus versus cyclosporine in lung transplantation Ann Thorac Surg 60 1995 580 584
8. H. Treede, W. Klepetko, H. Reichenspurner Tacrolimus versus cyclosporine after lung transplantation: a prospective, open, randomized two-center trial comparing two different immunosuppressive protocols J Heart Lung Transplant 20 2001 511 517
9. A. Zuckermann, H. Reichenspurner, T. Birsan Cyclosporine A versus tacrolimus in combination with mycophenolate mofetil and steroids as primary immunosuppression after lung transplantation: one-year results of a 2-center prospective randomized trial J Thorac Cardiovasc Surg 125 2003 891 900
10. K. Sarahrudi, M. Estenne, P. Corris International experience with conversion from cyclosporine to tacrolimus for acute and chronic lung allograft rejection J Thorac Cardiovasc Surg 127 2004 1126 1132
11. N.H. Sigal, C.S. Lin, J.J. Siekierka Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A Transplant Proc 23 suppl 2 1991 1 5
12. J. Cairn, T. Yek, N.R. Banner Time-related changes in pulmonary function after conversion to tacrolimus in bronchiolitis obliterans syndrome J Heart Lung Transplant 22 2003 50 57
13. K. McNeil, A.R. Glanville, T. Wahlers Comparison of mycophenolate mofetil and azathioprine for prevention of bronchiolitis obliterans syndrome in de novo lung transplant recipients Transplantation 81 2006 998 1003
14. D.J. Ross, P.F. Waters, M. Levine Mycophenolate mofetil versus azathioprine immunosuppressive regimens after lung transplantation: preliminary experience J Heart Lung Transplant 17 1998 768 774
15. A. Zuckermann, W. Klepetko, T. Birsan Comparison between mycophenolate mofetil- and azathioprine-based immunosuppressions in clinical lung transplantation J Heart Lung Transplant 18 1999 432 440
16. European Mycophenolate Mofetil Cooperative Study Group Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection Lancet 345 1995 1321 1325
17. The Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation Transplantation 61 1996 1029 1037
18. J. Kobashigawa, L. Miller, D. Renlund A randomized active-controlled trial of mycophenolate mofetil in heart transplant recipients Transplantation 66 1998 507 515
19. A.R. Glanville, C.L. Aboyoun, J.M. Morton Cyclosporine C2 target levels and acute cellular rejection after lung transplantation J Heart Lung Transplant 25 2006 928 934
20. K.F. Schulz, D.G. Altman, D. Moher CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials BMJ 340 2010 c332
21. J.D. Hosenpud, L.E. Bennett, B.M. Keck The registry of the International Society for Heart and Lung Transplantation: seventeenth official report - 2000 J Heart Lung Transplant 19 2000 909 931
22. H. Jiang, C. Wynn, F. Pan Tacrolimus and cyclosporine differ in their capacity to overcome ongoing allograft rejection as a result of their differential abilities to inhibit interleukin-10 production Transplantation 73 2002 1808 1817
23. A. Khanna, V. Cairns, J.D. Hosenpud Tacrolimus induces increased expression of transforming growth factor-beta1 in mammalian lymphoid as well as nonlymphoid cells Transplantation 67 1999 614 619
24. K.R. McCurry, D.B. Zaldonis, R.J. Keenan Long-term follow-up of a prospective randomized trial of tacrolimus versus cyclosporine in human lung transplantation Am J Transplant 2 suppl 3 2002 159
25. A.R. Glanville, C.L. Aboyoun, A. Havryk Severity of lymphocytic bronchiolitis predicts long-term outcome after lung transplantation Am J Respir Crit Care Med 177 2008 1033 1040