Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function

Journal of Nephrology

Volumn 25, Issue 3, 2012, Pages 426-430

  Meng, Lei ^a   Yang, Ying ^a   Qi, Li Tong ^a   Wang, Xue jing ^a   Xu, Guo Bin ^a   Zhang, Bao Wei ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Cardiovascular events; Cystatin C; Predictor

Indexed keywords

CYSTATIN C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

AGED; ARTICLE; CARDIOVASCULAR DISEASE; CHINA; CHOLESTEROL BLOOD LEVEL; COMMUNITY HOSPITAL; CONTROLLED STUDY; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; PREDICTION; PROTEIN BLOOD LEVEL; RISK FACTOR; URBAN AREA;

AGED; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CHI-SQUARE DISTRIBUTION; CHINA; CROSS-SECTIONAL STUDIES; CYSTATIN C; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT; RISK FACTORS; UP-REGULATION;

EID: 84863336156     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/jn.5000020     Document Type: Article

References (15)

1. Levey AS, Eckardt KU, Tsukamoto Y, et al. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2005;67(6):2089-2100.
2. Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis. 2002;40(2):221-226.
3. Aucella F, Guida CC, Lauriola V, Vergura M. How to assess renal function in the geriatric population. J Nephrol. 2010;23(Suppl 15):S46-S54.
4. Shlipak MG, Sarnak MJ, Katz R, et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 2005;352(20):2049-2060.
5. Ix JH, Shlipak MG, Chertow GM, Whooley MA. Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul Study. Circulation. 2007;115(2):173-179.
6. Ma YC, Zuo L, Chen JH, et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol. 2006;17(10):2937-2944.
7. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296-1305.
8. Seliger SL, Davis C, Stehman-Breen C. Gender and the progression of renal disease. Curr Opin Nephrol Hypertens. 2001;10(2):219-225.
9. Perkins BA, Nelson RG, Ostrander BE, et al. Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration: results of a 4-year follow-up study. J Am Soc Nephrol. 2005;16(5):1404-1412.
10. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2)(Suppl 1):S1-S266
11. Shlipak MG, Katz R, Sarnak MJ, et al. Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med. 2006;145(4):237-246.
12. Madero M, Wassel CL, Peralta CA, et al; Health ABC Study. Cystatin C associates with arterial stiffness in older adults. J Am Soc Nephrol. 2009;20(5):1086-1093.
13. Koenig W, Twardella D, Brenner H, Rothenbacher D. Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate. Clin Chem. 2005;51(2):321-327.
14. Sarnak MJ, Katz R, Stehman-Breen CO, et al; Cardiovascular Health Study. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med. 2005;142(7):497-505.
15. O'Hare AM, Newman AB, Katz R, et al. Cystatin C and incident peripheral arterial disease events in the elderly: results from the Cardiovascular Health Study. Arch Intern Med. 2005;165(22):2666-2670.