Novel fatty acid gentamicin salts as slow-release drug carrier systems for anti-infective protection of vascular biomaterials

Journal of Materials Science: Materials in Medicine

Volumn 23, Issue 7, 2012, Pages 1675-1683

  Obermeier, A ^a   Matl, F D ^a   Schwabe, J ^b   Zimmermann, A ^a   Kuhn K D ^c   Lakemeier, S ^d   Eisenhart Rothe, R V ^a   Stemberger, A ^a   Burgkart, R ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b ALFRIED KRUPP KRANKENHAUS   (Germany)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

^d UNIVERSITY HOSPITAL MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL GROWTH; BIOCOMPATIBLE COATINGS; DRUG CARRIER SYSTEMS; DRUG FORMULATIONS; DRUG RELEASE; DRUG RELEASE KINETICS; ELISA ASSAY; FATTY ACID SALTS; HAEMOCOMPATIBILITY; HIGH CONCENTRATION; IN-VITRO EVALUATION; LAURATE; SLOW RELEASE; SODIUM DODECYL SULFATE; VASCULAR PROSTHESIS;

BIOCOMPATIBILITY; BIOLOGICAL MATERIALS; POLYETHYLENE TEREPHTHALATES; SALTS; SODIUM SULFATE;

COATINGS;

ANTIINFECTIVE AGENT; DODECYL SULFATE SODIUM; GENTA L; GENTA P; GENTA SDS; GENTAMICIN; GENTAMICIN LAURATE; GENTAMICIN PALMITATE; GENTAMICIN SODIUM DODECYL SULFATE; LAURIC ACID; PALMITIC ACID; RIFAMPICIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; BLOOD VESSEL PROSTHESIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG COATING; DRUG EFFICACY; DRUG FORMULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; INFECTION PREVENTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTHESIS INFECTION; SLOW DRUG RELEASE; THROMBOELASTOGRAPHY;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; BIOCOMPATIBLE MATERIALS; BLOOD VESSEL PROSTHESIS; DRUG CARRIERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENTAMICINS; MICE; MICROSCOPY, ELECTRON, SCANNING;

BACTERIA (MICROORGANISMS);

EID: 84863335349     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-012-4631-5     Document Type: Article

References (16)

1. Saleem BR, Meerwaldt R, Tielliu IF, Verhoeven EL, van den Dungen JJ, Zeebregts CJ. Conservative treatment of vascular prosthetic graft infection is associated with high mortality. Am J Surg. 2010;200(1):47-52.
2. Twine CP, McLain AD. Graft type for femoro-popliteal bypass surgery. Cochrane Database Syst Rev. 2010;5:CD001487.
3. Vollmar J, Buettner-Ristow A. Diagnostic and clinical aspects of septic complications in vascular surgery (author's transl). Langenbecks Arch Chir. 1976;342:505-9.
4. Pounds LL, Montes-Walters M, Mayhall CG, Falk PS, Sanderson E, Hunter GC, et al. A changing pattern of infection after major vascular reconstructions. Vasc Endovascular Surg. 2005;39(6): 511-7. (Pubitemid 41790143)
5. Bandyk DF, Novotney ML, Back MR, Johnson BL, Schmacht DC. Expanded application of in situ replacement for prosthetic graft infection. J Vasc Surg. 2001;34(3):411-9.
6. Kaebnick HW, Bandyk DF, Bergamini TW, Towne JB. The microbiology of explanted vascular prostheses. Surgery. 1987; 102(4):756-62. (Pubitemid 18021247)
7. Lehnhardt FJ, Torsello G, Claeys LG, Pfeiffer M, Wachol-Drewek Z, Grundmann RT, et al. Systemic and local antibiotic prophylaxis in the prevention of prosthetic vascular graft infection: an experimental study. Eur J Vasc Endovasc Surg. 2002;23(2):127-33. (Pubitemid 41079475)
8. Turgut H, Sacar S, Kaleli I, Sacar M, Goksin I, Toprak S, et al. Systemic and local antibiotic prophylaxis in the prevention of Staphylococcus epidermidis graft infection. BMC Infect Dis. 2005;5:91.
9. Vogt S, Kühn KD, Gopp U, Schnabelrauch M. Resorbable antibiotic coatings for bone substitutes and implantable devices. Materialwiss Werkstofftech. 2005;36(12):814-9. (Pubitemid 43058084)
10. Uckay I, Pittet D, Vaudaux P, Sax H, Lew D, Waldvogel F. Foreign body infections due to Staphylococcus epidermidis. Ann Med. 2009;41(2):109-19.
11. Schwank S, Rajacic Z, Zimmerli W, Blaser J. Impact of bacterial biofilm formation on in vitro and in vivo activities of antibiotics. Antimicrob Agents Chemother. 1998;42(4):895-8. (Pubitemid 28216374)
12. Ginalska G, Osinska M, Uryniak A, Urbanik-Sypniewska T, Belcarz A, Rzeski W, et al. Antibacterial activity of gentamicin-bonded gelatin-sealed polyethylene terephthalate vascular prostheses. Eur J Vasc Endovasc Surg. 2005;29(4):419-24. (Pubitemid 40331379)
13. Edmiston CE Jr, Goheen MP, Seabrook GR, Johnson CP, Lewis BD, Brown KR, et al. Impact of selective antimicrobial agents on staphylococcal adherence to biomedical devices. Am J Surg. 2006;192(3):344-54. (Pubitemid 44223382)
14. Matl FD, Obermeier A, Repmann S, Friess W, Stemberger A, Kuehn KD. New anti-infective coatings of medical implants. Antimicrob Agents Chemother. 2008;52(6):1957-63. (Pubitemid 351758530)
15. Kuehn KD. In vitro release of gentamicinpalmitate coating in uncemented titanium implants. IJNBM. 2010;3(1):94-106.
16. Kuehn KD, Bruenke J. Effectiveness of a novel gentamicinpalmitate coating on biofilm formation of Staphylococcus aureus and Staphylococcus epidermidis. IJNBM. 2010;3(1):107-17.