Duramycin exhibits antiproliferative properties and induces apoptosis in tumour cells

Blood Coagulation and Fibrinolysis

Volumn 23, Issue 5, 2012, Pages 396-401

  Yates, Katherine R ^a   Welsh, Jessica ^a   Udegbunam, Nkeiruka O ^a   Greenman, John ^a   Maraveyas, Anthony ^b   Madden, Leigh A ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

^b CASTLE HILL HOSPITAL   (United Kingdom)

Author keywords

duramycin; phosphatidylethanolamine; thrombosis; tissue factor

Indexed keywords

LANCOVUTIDE; PHOSPHATIDYLETHANOLAMINE; THROMBOPLASTIN;

ANTICOAGULATION; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELL SURFACE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ELECTRON MICROSCOPY; FLOW CYTOMETRY; MEMBRANE STRUCTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BACTERIOCINS; CELL ADHESION; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; NECROSIS; PEPTIDES; PHOSPHATIDYLETHANOLAMINES; THROMBOPLASTIN;

EID: 84863334459     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0b013e3283538875     Document Type: Article

References (21)

1. Khorana AA, Fine RL. Pancreatic cancer and thromboembolic disease. Lancet Oncol 2004; 5:655-663. (Pubitemid 40267849)
2. Khorana AA, Ahrendt SA, Ryan CK, Francis CW, Hruban RH, Hu YC, et al. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res 2007; 13:2870-2875. (Pubitemid 46849560)
3. Echrish H, Madden LA, Greenman J, Maraveyas A. The haemostasis apparatus in pancreatic cancer and its importance beyond thrombosis. Cancers 2011; 3:267-284.
4. Echrish HH, Madden L, Greenman J, Wedgewood K, Dasgupta D, Maraveyas A. Prothrombotic indices and invasive-angiogenic properties of blood from pancreatic cancer (PC) patients improve after cancer resection: a prospective controlled study. J Thromb Haem 2011; 9:434-1434.
5. Stafford JH, Thorpe PE. Increased exposure of phosphatidylethanolamine on the surface of tumor vascular endothelium. Neoplasia 2011; 13:299-308.
6. Smith AS. The cell based model of coagulation. J Vet Emerg Crit Care 2009; 19:3-10.
7. Zhao M, Li Z, Bugenhagen S. 99mTc-labeled duramycin as a novel phosphatidylethanolamine-binding molecular probe. J Nucl Med 2008; 49:1345-1352.
8. Vance JE. Phosphatidylserine and phosphatidylethanolamine in mammalain cells: two metabolically similar relation aminophospholipids. J Lipid Res 2008; 40:1377-1383.
9. Marconescu A, Thorpe PE. Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells. Biochim Biophys Acta 2008; 1778:2217-2224.
10. De Saint-Hubert M, Prinsen K, Mortelmans L, Verbruggen A, Mottaghy FM. Molecular imaging of cell death. Methods 2009; 48:178-187.
11. Hayashi F, Nagashima K, Terui Y, Kawamura Y, Matsumoto K, Itazaki H. The structure of PA48009: the revised structure of duramycin. J Antibiot (Tokyo) 1990; 43:1421-1430. (Pubitemid 20378500)
12. Yates K, Welsh J, Echrish H, Greenman J, Maraveyas A, Madden LA. Pancreatic cancer cell and microparticle procoagulant surface characterisation: involvement of membrane expressed tissue factor, phosphatidylserine and phosphatidylethanolamine. Blood Coagul Fibrinolysis 2011; 22:680-687.
13. Zachowski A. Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement. Biochem J 1993; 294:1-14. (Pubitemid 23251903)
14. Falls LA, Furie B, Furie BC. Role of phosphatidylethanolamine in assembly and function of the factor IXa-Factor VIIIa complex on membrane surfaces. Biochemistry 2000; 39:13216-13222.
15. Neuenschwander PF, Biancofisher E, Rezaie AR, Morrissey JH. Phosphatidylethanolamine augments factor viia-tissue factor activity: enhancement of sensitivity to phosphatidylserine. Biochemistry 1995; 34:13988-13993.
16. Iwamoto K, Hayakawa T, Murate M, Makino A, Ito K, Fujisawa T, et al. Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin. Biophys J 2007; 93:1608-1619. (Pubitemid 47403302)
17. Rzeznicka II, Sovago M, Backus EH, Bonn M, Yamada T, Kobayashi T, et al. Duramycin-induced destabilization of a phosphatidylethanolamine monolayer at the air-water interface observed by vibrational sum-frequency generation spectroscopy. Langmuir 2010; 26:16055-16062.
18. Matsunaga S, Matsunaga T, Iwamoto K, Yamada T, ShibayamaM, Kawai M, et al. Visualization of phospholipid particle fusion induced by duramycin. Langmuir 2009; 25:8200-8207.
19. Choung SY, Kobayashi T, Inoue J, Takemoto K, Ishitsuka H, Inoue K. Hemolytic activity of a cyclic peptide Ro09-0198 isolated from Streptoverticillium. Biochim Biophys Acta 1988; 940:171-179.
20. Zhao M. Lantibiotics as probes for phosphatidylethanolamine. Amino Acids 2011; 41:1071-1079. 21
21. Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism. Circulation 2003; 107:I9-16.