5-fluorouracil induced hyperammonemic encephalophathy: Etiopathologic correlation

Canadian Journal of Neurological Sciences

Volumn 39, Issue 4, 2012, Pages 553-554

  Martínez De Lapiscina, Elena Hernández ^a   Erro Aguirre, María Elena ^a   Giadás, Teresa Cabada ^a   Tuñón Álvarez, María Teresa ^a  

^a Instituto de Investigación Sanitaria de Navarra   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ADULT; BLOOD CELL COUNT; BRAIN DISEASE; CANCER COMBINATION CHEMOTHERAPY; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CORRELATION ANALYSIS; FEMALE; HUMAN; HYPERAMMONEMIC ENCEPHALOPATHY; LETTER; MEDICAL HISTORY; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RECTUM CARCINOMA;

EID: 84863330382     PISSN: 03171671     EISSN: None     Source Type: Journal    
DOI: 10.1017/s0317167100018205     Document Type: Letter

References (5)

1. Yeh KH, Cheng AL. High-dose 5-fluorouracil infusional therapy is associated with hyperammonaemia, lactic acidosis and encephalopathy. Br J Cancer. 1997;75(3):464-5.
2. nott L, Price TJ, Pittman K, Patterson K, fletcher J. Hyperammonemia encephalopathy: an important cause of neurological deterioration following chemotherapy. Leuk Lymphoma. 2007;48(9):1702-11.
3. Koenig H, Patel A. Biochemical basis for fluorouracil neurotoxicity. The role of Krebs cycle inhibition by fluoroacetate. Arch neurol. 1970;23(2):155-60.
4. Kim SR, Park CH, Park S, Park Jo, Lee J, Lee SY. genetic polymorphisms associated with 5-fluorouracil-induced neurotoxicity. Chemotherapy. 2010; 56(4):313-7.
5. Takanashi J, Barkovich AJ, Cheng Sf, et al. Brain MR imaging in neonatal hyperammonemic encephalopathy resulting from proximal urea cycle disorders. AJnR Am J neuroradiol. 2003;24(6):1184-7.