A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy

Cancer

Volumn 118, Issue 14, 2012, Pages 3654-3665

  Mak, Raymond H ^a   Alexander, Brian M ^b   Asomaning, Kofi ^c   Heist, Rebecca S ^c,d   Liu, Chen Yu ^c,e   Su, Li ^c   Zhai, Rihong ^c   Ancukiewicz, Marek ^d   Napolitano, Brian ^d   Niemierko, Andrzej ^d   Willers, Henning ^d   Choi, Noah C ^d   Christiani, David C ^c  

^a HARVARD RADIATION ONCOLOGY PROGRAM   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

lung cancer; MTHFR; oxidative stress; radiation pneumonitis; single nucleotide polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DOCETAXEL; MANGANESE SUPEROXIDE DISMUTASE;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER RADIOTHERAPY; CHEMORADIOTHERAPY; COHORT ANALYSIS; CONSOLIDATION CHEMOTHERAPY; DISEASE SEVERITY; DOSIMETRY; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HUMAN; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; METHYLENE TETRAHYDROFOLATE REDUCTASE GENE; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION PNEUMONIA; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; SUPEROXIDE DISMUTASE 2 GENE;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RADIATION DOSAGE; RADIATION PNEUMONITIS; RADIOTHERAPY; RISK; RISK FACTORS;

EID: 84863325974     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.26667     Document Type: Article

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