Radiation-induced synthesis and swelling properties of p(2-hydroxyethyl methacrylate/itaconic acid/oligo (ethylene glycol) acrylate) terpolymeric hydrogels

Radiation Physics and Chemistry

Volumn 81, Issue 9, 2012, Pages 1451-1455

  Micic, M ^a   Stamenic, D ^b   Suljovrujic, E ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

P(HEMA IA OEGA); Radiation synthesis; Stimuli responsive hydrogels; Swelling

Indexed keywords

2-HYDROXYETHYL METHACRYLATE; BIOACTIVE MOLECULES; CARBOXYL GROUPS; COMONOMERS; CONTROLLED DELIVERY; EQUILIBRIUM SWELLING; ITACONIC ACID; MECHANICAL MEASUREMENTS; MOLE FRACTION; MOLE RATIO; OLIGO(ETHYLENE GLYCOL); PH SENSITIVITY; PH VALUE; PH-RESPONSIVE; RADIATION SYNTHESIS; RADIATION-INDUCED SYNTHESIS; STIMULI-RESPONSIVE; STRUCTURE AND PROPERTIES; SWELLING CAPACITIES; SWELLING PROPERTIES; SWELLING STUDIES; TEMPERATURE RANGE; TEMPERATURE-RESPONSIVE;

ETHYLENE GLYCOL; FOURIER TRANSFORM INFRARED SPECTROSCOPY; PROTEINS; SCANNING ELECTRON MICROSCOPY; SWELLING;

HYDROGELS;

2 HYDROXYETHYL METHACRYLATE; ITACONIC ACID; OLIGO(ETHYLENE GLYCOL) ACRYLATE; OLIGOMER; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; GAMMA RADIATION; HYDROGEL; INFRARED SPECTROSCOPY; PH; SCANNING ELECTRON MICROSCOPY; SWELLING; TEMPERATURE;

EID: 84863309149     PISSN: 0969806X     EISSN: 18790895     Source Type: Journal    
DOI: 10.1016/j.radphyschem.2011.11.024     Document Type: Article

References (21)

1. Becer C.R., et al. Libraries of methacrylic acid and oligo(ethylene glycol) methacrylate copolymers with LCST behavior. J. Polym. Sci. Part A: Polym. Chem. 2008, 46(21):7138-7147.
2. Bettini R., Colombo P., Peppas N.A. Solubility effects on drug transport through pH-sensitive, swelling-controlled release systems: transport of theophylline and metoclopramide monohydrochloride. J. Controlled Release 1995, 37(1-2):105-111.
3. Ferreira L., Vidal M.M., Gil M.H. Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values. Int. J. Pharm. 2000, 194(2):169-180.
4. Garcia D.M., et al. Timolol maleate release from pH-sensible poly(2-hydroxyethyl methacrylate-co-methacrylic acid) hydrogels. Eur. Polym. J. 2004, 40(8):1683-1690.
5. Goh E.C.C., Stöver H.D.H. Cross-linked poly(methacrylic acid-co-poly(ethylene oxide) methyl ether methacrylate) microspheres and microgels repared by precipitation polymerization-a morphology study. Macromolecules 2002, 35(27):9983-9989.
6. Harris J.M. Introduction to biotechnical and biomedical applications of poly(ethylene glycol). Poly(ethylene glycol) Chemistry: Biotechnical and Biomedical Applications 1992, 1-12. J.M. Harris (Ed.).
7. Johnson B.D., Beebe D.J., Crone W. Effects of swelling on the mechanical properties of a pH-sensitive hydrogel for use in microfluidic devices. Mater. Sci. Eng. C: Biom. and Supramolecular Systems 2004, 24(4):575-581.
8. Jones J.A., et al. Thermoresponsive copolymers of methacrylic acid and poly(ethylene glycol) methyl ether methacrylate. J. Polymer Sci. Part A: Polymer Chem. 2005, 43(23):6095-6104.
9. Khare A.R., Peppas N.A. Swelling/deswelling of anionic copolymer gels. Biomater. 1995, 16(7):559-567.
10. Lutz J.F. Polymerization of oligo(ethylene glycol) (meth)acrylates: toward new generations of smart biocompatible materials. J. Polymer Sci. Part A: Polymer Chem. 2008, 46(11):3459-3470.
11. Lutz J.F., Weichenhan K., Akdemir O., Hoth A. About the phase transitions in aqueous solutions of thermoresponsive copolymers and hydrogels based on 2-(2-methoxyethoxy)ethyl methacrylate and oligo(ethylene glycol) methacrylate. Macromolecules 2007, 40(7):2503-2508.
12. Mantovani G., et al. Design and synthesis of N-maleimido-functionalized hydrophilic polymers via copper-mediated living radical polymerization: a suitable alternative to PEGylation chemistry. J. Am. Chem. Soc. 2005, 127(9):2966-2973.
13. Ottenbrite R.M., Park K., Okano T. Biomedical Applications of Hydrogels Handbook 2010, Springer, New York.
14. Paris R., Quijada-Garrido I. Swelling behaviour of thermo-sensitive hydrogels based on oligo(ethylene glycol) methacrylates. Eur. Polymer J. 2009, 45(12):3418-3425.
15. Rosiak, J.M., 2002. Radiation Formation of Hydrogels for Biomedical Applications.
16. Safrany A., Beiler B., Vincze A. Radiation polymerization and crosslinking-a viable alternative for synthesis of porous functional polymers. Radiat. Phys. Chem. 2010, 79(4):462-466.
17. Schild H.G. Poly(N-isopropylacrylamide)-experiment, theory and application. Prog. Polymer Sci. 1992, 17(2):163-249.
18. Sen M., Yakar A. Controlled release of antifungal drug terbinafine hydrochloride from poly(N-vinyl 2-pyrrolidone/itaconic acid) hydrogels. Int. J. Pharm. 2001, 228(1-2):33-41.
19. Tomic S.L., Micic M.M., Filipovic J.M., Suljovrujic E.H. Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation. Radiat. Phys. Chem. 2007, 76(5):801-810.
20. Tomic S.L.J., Micic M.M., Filipovic J.M., Suljovrujic E.H. Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol) meth)acrylates hydrogels. Chem. Eng. J. 2010, 160(2):801-809.
21. Wang J., Wu W. Swelling behaviors, tensile properties and thermodynamic studies of water sorption of 2-hydroxyethyl methacrylate/epoxy methacrylate copolymeric hydrogels. Eur. Polymer J. 2005, 41(5):1143-1151.