Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells

Biochemical and Biophysical Research Communications

Volumn 423, Issue 3, 2012, Pages 467-472

  Huang, Shuai ^a   Tang, Yubo ^b   Cai, Xingdong ^c   Peng, Xinsheng ^c   Liu, Xingmo ^a   Zhang, Longjuan ^c   Xiang, Yucheng ^a   Wang, Dechun ^a   Wang, Xi ^a   Pan, Tao ^a  

^a THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Akt; Bone marrow derived endothelial progenitor cells; Celastrol; Endothelial nitric oxide synthase (eNOS); Vasculogenesis; VEGFR2

Indexed keywords

CELASTROL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ADULT; AGED; ANGIOGENESIS; ARTICLE; BONE MARROW; CELL ADHESION; CELL FUNCTION; CELL MIGRATION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIAL PROGENITOR CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION;

ADULT; AGED; ANGIOGENESIS INHIBITORS; BONE MARROW CELLS; CELL SURVIVAL; CELLS, CULTURED; CHEMOTAXIS; ENDOTHELIUM, VASCULAR; HUMANS; MICROVESSELS; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STEM CELLS; TRITERPENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84863308389     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.05.143     Document Type: Article

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