Autologous transplantation of adipose-derived mesenchymal stem cells attenuates cerebral ischemia and reperfusion injury through suppressing apoptosis and inducible nitric oxide synthase

International Journal of Molecular Medicine

Volumn 29, Issue 5, 2012, Pages 848-854

  Li, Dehua ^a   Fang, Yan ^a   Wang, Pan ^a   Shan, Wei ^a   Zuo, Zhongfu ^a   Xie, Ling ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Adipose derived mesenchymal stem cells; Apoptosis; Cerebral ischemia and reperfusion injury; Inducible nitric oxide synthase; Neuroprotection

Indexed keywords

BETA1 INTEGRIN; CASPASE 3; CD31 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; MICROSOMAL AMINOPEPTIDASE; NITRIC OXIDE; PROTEIN BAX; PROTEIN BCL 2; THY 1 ANTIGEN;

ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN NERVE CELL; BRAIN PROTECTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADIPOSE TISSUE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN; BRAIN ISCHEMIA; CASPASE 3; DOWN-REGULATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TRANSPLANTATION, AUTOLOGOUS;

EID: 84863265891     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.909     Document Type: Article

References (35)

1. Donnan GA, Fisher M, Macleod M and Davis SM: Stroke. Lancet 371: 1612-1623, 2008. (Pubitemid 351626845)
2. Roger VL, Go AS, Lloyd-Jones DM, et al: Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation 123: e18-e209, 2011.
3. Woitzik J, Back T and Thome C: Flow-dependent versus spreading-like impairment of brain tissue integrity during focal cerebral ischemia and its consequences for neuroprotective strategies. Front Biosci 13: 1500-1506, 2008. (Pubitemid 351606116)
4. Li Q, Zhang R, Guo YL and Mei YW: Effect of neuregulin on apoptosis and expressions of STAT3 and GFAP in rats following cerebral ischemic reperfusion. J Mol Neurosci 37: 67-73, 2009.
5. Ginsberg MD: Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology 55: 363-389, 2008.
6. Goldstein LB and Rothwell PM: Advances in prevention and health services delivery 2009. Stroke 41: e71-e73, 2010.
7. Pittenger MF, Mackay AM, Beck SC, et al: Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147, 1999. (Pubitemid 29282067)
8. Liu ZJ, Zhuge Y and Velazquez OC: Trafficking and differentiation of mesenchymal stem cells. J Cell Biochem 106: 984-991, 2009.
9. Ma T: Mesenchymal stem cells: from bench to bedside. World J Stem Cells 2: 13-17, 2010.
10. Locke M, Windsor J and Dunbar PR: Human adipose-derived stem cells: isolation, characterization and applications in surgery. ANZ J Surg 79: 235-244, 2009.
11. Leu S, Lin YC, Yuen CM, et al: Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. J Transl Med 8: 63, 2010.
12. Chen YT, Sun CK, Lin YC, et al: Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction. J Transl Med 9: 51, 2011.
13. Sun CK, Yen CH, Lin YC, et al: Autologous transplantation of adipose-derived mesenchymal stem cells markedly reduced acute ischemia-reperfusion lung injury in a rodent model. J Transl Med 9: 118, 2011.
14. Zuk PA, Zhu M, Ashjian P, et al: Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13: 4279-4295, 2002. (Pubitemid 35471185)
15. Longa EZ, Weinstein PR, Carlson S and Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91, 1989. (Pubitemid 19040218)
16. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C and Sharp FR: A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 10: 290-293, 1990. (Pubitemid 20096202)
17. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408, 2001. (Pubitemid 34164012)
18. Strem BM, Hicok KC, Zhu M, et al: Multipotential differentiation of adipose tissue-derived stem cells. Keio J Med 54: 132-141, 2005. (Pubitemid 41542713)
19. Wang L, Deng J, Tian W, et al: Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts. Am J Physiol Heart Circ Physiol 297: H1020-H1031, 2009.
20. Lamkanfi M, Festjens N, Declercq W, Vanden Berghe T and Vandenabeele P: Caspases in cell survival, proliferation and differentiation. Cell Death Differ 14: 44-55, 2007. (Pubitemid 44911893)
21. Burlacu A: Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 7: 249-257, 2003.
22. ArunaDevi R, Ramteke VD, Kumar S, et al: Neuroprotective effect of s-methylisothiourea in transient focal cerebral ischemia in rat. Nitric Oxide 22: 1-10, 2010.
23. Samdani AF, Dawson TM and Dawson VL: Nitric oxide synthase in models of focal ischemia. Stroke 28: 1283-1288, 1997. (Pubitemid 27248908)
24. Lin TN, He YY, Wu G, Khan M and Hsu CY: Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 24: 117-121, 1993. (Pubitemid 23014393)
25. Xing B, Chen H, Zhang M, et al: Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. Stroke 39: 2362-2369, 2008.
26. Krajewski S, Mai JK, Krajewska M, Sikorska M, Mossakowski MJ and Reed JC: Upregulation of bax protein levels in neurons following cerebral ischemia. J Neurosci 15: 6364-6376, 1995. (Pubitemid 3001286)
27. Chen J, Zhu RL, Nakayama M, et al: Expression of the apoptosis-effector gene, Bax, is upregulated in vulnerable hippocampal CA1 neurons following global ischemia. J Neurochem 67: 64-71, 1996. (Pubitemid 26185581)
28. Iadecola C, Pelligrino DA, Moskowitz MA and Lassen NA: Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab 14: 175-192, 1994. (Pubitemid 24064431)
29. Li H and Forstermann U: Nitric oxide in the pathogenesis of vascular disease. J Pathol 190: 244-254, 2000. (Pubitemid 30141371)
30. Marletta MA: Nitric oxide synthase: aspects concerning structure and catalysis. Cell 78: 927-930, 1994.
31. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC and Moskowitz MA: Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265: 1883-1885, 1994. (Pubitemid 24324247)
32. Zhao X, Haensel C, Araki E, Ross ME and Iadecola C: Gene-dosing effect and persistence of reduction in ischemic brain injury in mice lacking inducible nitric oxide synthase. Brain Res 872: 215-218, 2000. (Pubitemid 30618907)
33. Sims NR and Anderson MF: Mitochondrial contributions to tissue damage in stroke. Neurochem Int 40: 511-526, 2002. (Pubitemid 34159152)
34. Zhang F and Iadecola C: Reduction of focal cerebral ischemic damage by delayed treatment with nitric oxide donors. J Cereb Blood Flow Metab 14: 574-580, 1994. (Pubitemid 24198399)
35. Huang Z, Huang PL, Ma J, et al: Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine. J Cereb Blood Flow Metab 16: 981-987, 1996. (Pubitemid 26292066)