Immunomodulatory effect of withania somnifera, asparagus racemosus and picrorhiza kurroa roots

International Journal of Pharmacology

Volumn 8, Issue 2, 2012, Pages 108-114

  Siddiqui, Nasir Ali ^a   Singh, Shobhna ^b   Siddiquei, M Mairaj ^c   Khan, Tajdar Husain ^d  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b M J P ROHILKHAND UNIVERSITY   (India)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d PRINCE SATTAM BIN ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Antibody; Cyclophosphamide; Immunomodulatory; Neutrophils; Polyherbal; Withania somnifera

Indexed keywords

ALCOHOL; ASPARAGUS RACEMOSUS EXTRACT; CARBOXYMETHYLCELLULOSE; CYCLOPHOSPHAMIDE; ERYTHROCYTE ANTIGEN; HUMORAL ANTIBODY; PICRORHIZA KURROA EXTRACT; WITHANIA SOMNIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; ASPARAGUS RACEMOSUS; BODY WEIGHT; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; FOOT PAD; HERB; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOMODULATION; IMMUNOSTIMULATION; MALE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PICRORHIZA KURROA; PLANT ROOT; POWDER; SUSPENSION; WITHANIA SOMNIFERA;

EID: 84863231776     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2012.108.114     Document Type: Article

References (25)

1. Askenase, P.W. and H. van Loverent, 1983. Delayed type hypersensitivity: Activation of mast cells by antigen specific T-cell factors initiates cascade of cellular interactions. Trends Immunol., 4: 259-264.
2. Banerjee, D., B. Maity, S.K. Nag, S.K. Bandyopadhyay and S. Chattopadhyay, 2008. Healing potential of Picrorhiza kurroa (Scrophulariaceae) rhizomes against indomethacin-induced gastric ulceration: A mechanistic exploration. BMC Complement. Altern. Med., 31: 8-3.
3. Bhattacharya, S.K., A. Bhattacharya and A. Chakrabarti, 2000. Adaptogenic activity of Siotone, a polyherbal formulation of Ayurvedic rasayanas. Indian J. Exp. Biol, 38: 119-128.
4. Davis, L. and G. Kuttan, 2000. Immunomodulatory activity of Withania somnifera. J. Ethnopharmacol., 71: 193-200.
5. Diwanay, S., D. Chitre and B. Patwardhan, 2004. Immunoprotection by botanical drugs in cancer chemotherapy. J. Ethnopharmacol., 90: 49-55.
6. Doherty, N. S., 1981. Selective effects of immunosuppressive agents against the delayed type hypersensitivity response and humoral response to sheep red blood cells in mice. Agents Actions, 11: 237-242.
7. Gaur, S. and P. Kaushik, 2011. Influence of edaphic factors on distribution of mycorrhiza associated with medicinal plants in Indian central Himalayas. J. Biol. Sci., 11: 349-358.
8. Grover, A., A. Shandilya, A. Punetha, V.S. Bisaria and D. Sundar, 2010. Inhibition of the NEMO/IKK [3 association complex formation, a novel mechanism associated with the NF- kB activation suppression by Withania somnifera's key metabolite withaferin A. Biol. Med. Chem. Genomics., 4: S25-S36.
9. Hashemi, S.R. and H. Davoodi, 2012. Herbal plants as new immuno-stimulator in poultry industry: A review. Asian J. Anim. Vet. Adv., 7: 105-116.
10. Meera, S., V.S.S.S. Gupta Atyam and N.S. Kumar, 2008. Immunomodulatory and antioxidant activity of a polyherbal formulation. Int. J. Pharmacol., 4: 287-291.
11. Muruganandam, A.V., V. Kumar and S.K. Bhattacharya, 2002. Effect of polyherbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Ind. J. Exp. Biol., 40: 1151-1160.
12. Nandagopal, M., P. Muralidharan and G. Thirumurugan, 2011. Cerebroprotective effect of root extract of Asparagus racemosus Willd. in global cerebral ischemia in rats. J. Pharmacol. Toxicol., 6: 49-61.
13. Oladunmoye, M.K., 2007. The immunostimulatory effects of ethanolic extract of Cassia alata on immune system of albino rats dosed with Staphylococcus aureus (NCIB 8588). J. Pharmacol. Toxicol., 2: 200-204.
14. Potduang, B., M. Meeploy, R. Giwanon, Y. Benmart, M. Kaewduang and W. Supatanakul, 2008. Biological activities of Asparagus racemosus. Afr. J. Tradit. Complement. Altern. Med., 5: 230-237.
15. Pretonus, E., H.M. Oberholzer and P.J. Becker, 2009. Comparing the cytotoxic potential of Withania somnifera water andmethanol extracts. Afr. J. Tradit. Complement. Altern. Med., 6: 275-280.
16. Pun, A., R. Saxena, K.C. Saxena and J.S. Tandon, 1994. Immunostimulant activity of Nyctanthes arbor-tritis L. J. Ethnopharmacol., 42: 31-37.
17. Rasool, M. and P. Varalakshmi, 2008. Antiperoxidative effect of Withania somnifera root powder on liver lipid peroxidation and antioxidant status in adjuvant-induced arthritic rats. Res. J. Medicinal Plant, 2: 28-33.
18. Rege, N.N. and S.A. Dhanukar, 1993. Quantitation of microbial activity of mononuclear phagocytes: As in vitro technique. J. Postgrad. Med., 39: 22-25.
19. Sarwar, M., I.H. Attitalla and M. Abdollahi, 2011. A review on the recent advances in pharmacological studies on medicinal plants: Animal studies are done but clinical studies needs completing. Asian J. Anim. Vet. Adv., 6: 867-883.
20. Sharma, P., P.S. Chauhan, P. Dutt, M. Amina and K.A. Suri et al., 2010. A unique immuno-stimulai steroidal sapogenin acid from the roots of Asparagi racemosus. Steroids, 76: 358-364.
21. Singh, S.K., U. Dimn, M. Kataria and P. Kumari, 2010 Ameliorative activity of Withania somnifera roi extract on paraquat-induced oxidative stress in mice. J. Pharmacol. Toxicol, 6: 433-439.
22. Uma, B., K. Prabhakar and S. Rajendran, 2009 Anticandidal activity of Asparagus racemosus. Indian. J. Pharm. Sci., 71: 342-343.
23. Velavan, S. and V.M.H. Begum, 2007. Restorative effect of Asparagus racemosus on age related oxidative damage in heart lysosome of aged rats. Int. J. Pharmacol, 3: 48-54.
24. Winters, M., 2006. Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern. Med. Rev., 11: 269-277.
25. Ziauddin, M., N. Phansalkar, P. Patki, S. Diwanay and B. Patwardhan, 1996. Studies on the immunomodulatory effects of ashwagandha. J. Ethnopharmacol., 50: 69-76.