Study on the complex hepatitis C vims antigen with multi-genotype E1 epitopes

Chinese Journal of Microbiology and Immunology

Volumn 29, Issue 1, 2009, Pages 46-52

  He, Feng ^a   Song, Xiao Guo ^a   Tang, Li ^a   Wang, Guo Hua ^a   Zhang, He Qiu ^a   Chen, Kun ^a   Zhu, Cui Xia ^a   Xu, Li Bo ^a   Ling, Shi Gan ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

B cell epitope; Hepatitis C virus; Multi type antigen complex

Indexed keywords

EID: 84863229557     PISSN: 02545101     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0254-5101.2009.01.012     Document Type: Article

References (15)

1. Seeff L B. Natural history of chronic hepatitis C. Hepatology, 2002, 36(5 Suppl1): S35-S46.
2. 2004, 24(11): 921-926.
3. Haqshenas G, Dong X, Netter H, et al. A chimeric GB virus B encoding the hepatitis C. virus hypervariable region 1 is infectious in vivo. J Gen Virol, 2007, 88(Pt 3): 895-902.
4. Goto J, Nishimura S, Esumi M, et al. Prevention of hepatitis C virus infection in a chimpanzee by vaccination and epitope mapping of antiserum directed against hypervariable region 1. Hepatol Res 2001, 19(3): 270-283.
5. 2002, 26 (2): 93-96.
6. Xiu B S, Ling S G, Song X G, et al. Cross-reactivity of hypervariable region 1 chimera of hepatitis C virus. World J Gastroenterol, 2003, 9(6): 1256-1260.
7. Keck Z Y, Sung V M, Perkins S, et al. Human monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity. J Virol, 2004, 78(13): 7257-7263.
8. Nevens F, Roskams T, Van Vlierberghe H, et al. A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C. Hepatology, 2003, 38(5): 1289-1296.
9. Leroux-Roels G, Depla E, Hulstaert F, et al. A candidate vaccine based on the hepatitis C E1 protein: tolerability and immunogenic-ity in healthy volunteers. Vaccine, 2004, 22(23-24): 3080-3086.
10. Leroux-Roels G, Batens AH, Desombere I, et al. Immunogenicity and tolerability of intradermal administration of an HCV E1-based vaccine candidate in healthy volunteers and patients with resolved or ongoing chronic HCV infection. Hum Vaccin, 2005, 1(2): 61-65.
11. 2001, 17(3): 231-233.
12. Siemoneit K, Cardoso Mda S, Koemer K, et al. Human monoclonal antibodies for the immunological characterization of a highly conserved protein domain of the hepatitis C virus glycoprotein E1. Clin Exp Immunol, 1995, 101(2): 278-283.
13. Choo Q L, Kuo G, Ralston R, et al. Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci USA, 1994, 91(4): 1294-1298.
14. 2003, 27(2): 110-114.
15. Yan J, Ling S, Liu H, et al. Induction of strong cytotoxic T lymphocyte responses to Hepatitis C virus with recombinant polyepitope in Balb/c mice. Viral Immunol, 2006, 19(1): 64-73.