Prediction and identification of antigenic epitopes in genus-specific outer membrane proteins OmpL1 and LipL21 of Leptospira interrogans

Chinese Journal of Microbiology and Immunology

Volumn 28, Issue 4, 2008, Pages 343-347

  Lin, Xu Ai ^a   Pan, Jian Ping ^a   Luo, Yi Hui ^a   Mao, Ya Fei ^a   Li, Li Wei ^a   Yan, Jie ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Antigenic epitope prediction; Genus specific envelope proteins; Leptospira interrogans; OmpL1 LipL21; Phage display identification

Indexed keywords

EID: 84863229449     PISSN: 02545101     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Sonrier C, Branger C, Michel V, et al. Evidence of cross-protection within Leptospira interrogans in an experimental model. Vaccine, 2000, 19(1): 86-94.
2. Haake D A, Chao G, Zuemer R L, et al. The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infection. Infect Immun, 2000, 68(4): 2276-2285.
3. 2004, 24(6): 439-444.
4. 2006, 26(11): 979-984.
5. Gnanasekar M, Rao K V, He Y X, et al. Novel phage display-based subtractive screening to identify vaccine candidates of Brugia malayi. Infect Immun, 2004, 72(8): 4707-4715.
6. Sette A, Fikes J. Epitope-based vaccines; an update on epitope identification, vaccine design and delivery. Curr Opin Immunol, 2003, 15(4): 461-470.
7. Day L A. Conformations of single-stranded DNA and coat protein in fd bacteriophage as revealed by ultraviolet absorption spectroscopy. J Mol Biol, 1969, 39: 265-277.
8. 2007, 47(2): 329-334.
9. Haake D A, Mazel M K, McCoy A M, et al. Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection. Infect Immun, 1999, 67(12): 6572-6582.
10. Cullen P A, Haake D A, Bulach D M, et al. LipL21 is a novel surface-exposed lipoprotein of pathogenic Leptospira species. Infect Immun, 2003, 71(5): 2414-2421.
11. Malm M, Rollman E, Ustav M, et al. Cross-clade protection induced by human immunodeficiency virus-1 DNA immunogens expressing consensus sequences of multiple genes and epitopes from subtypes A, B, C, and FGH. Viral Immunol, 2005, 18(4): 678-688.
12. Wang L F, Yu M. Epitope identification and discovery using phage display libraries: applications in vaccine development and diagnostics. Curr Drug Targets, 2004, 5(1): 1-15.
13. Smith G P. Filamentous fusion phage; novel expression vectors that display cloned antigens on the virion surface. Science, 1985, 228(2): 1315-1317.