Computer-based evolutionary search for a nonlinear conversion function for establishing in vitro-in vivo correlation (IVIVC) of oral drug formulations

Drug Metabolism and Pharmacokinetics

Volumn 27, Issue 3, 2012, Pages 280-285

  Yamashita, Fumiyoshi ^a   Fujita, Atsuto ^a   Zhang, Xingyi ^a   Sasa, Yukako ^a   Mihara, Kiyoshi ^c   Hashida, Mitsuru ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c MUSASHINO UNIVERSITY   (Japan)

Author keywords

Diltiazem; Genetic algorithm; Genetic expression programming; In vitro in vivo correlation; Nonlinear optimization; Sustained release

Indexed keywords

DILTIAZEM;

ARTICLE; ARTIFICIAL NEURAL NETWORK; COMPUTER PROGRAM; CORRELATION ANALYSIS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG RELEASE; DRUG SOLUBILITY; EVOLUTIONARY ALGORITHM; FEASIBILITY STUDY; GENE EXPRESSION SYSTEM; GENETIC ALGORITHM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MATHEMATICAL MODEL; PROCESS OPTIMIZATION; SUSTAINED RELEASE FORMULATION;

EID: 84863219203     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-RG-075     Document Type: Article

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