Endothelial cell-specific fgd5 involvement in vascular pruning defines neovessel fate in mice

Circulation

Volumn 125, Issue 25, 2012, Pages 3142-3158

  Cheng, Caroline ^a   Haasdijk, Remco ^a   Tempel, Dennie ^a   Van De Kamp, Esther H M ^a   Herpers, Robert ^a,b   Bos, Frank ^a,b   Den Dekker, Wijnand K ^a   Blonden, Lau A J ^a   De Jong, Renate ^a   Bürgisser, Petra E ^a   Chrifi, Ihsan ^a   Biessen, Erik A L ^c   Dimmeler, Stefanie ^d   Schulte Merker, Stefan ^b   Duckers, Henricus J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

angiogenesis inducing agents; apoptosis; endothelium; FGD5; models, animal

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; GUANOSINE TRIPHOSPHATASE; PROTEIN CDC42; PROTEIN P53;

AGING; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER REGRESSION; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; EMBRYO; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; ENZYME ACTIVATION; FGD5 GENE; GAIN OF FUNCTION MUTATION; GENE; GENE EXPRESSION; HISTOPATHOLOGY; LOSS OF FUNCTION MUTATION; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; RETINA; TRANSCRIPTOMICS; VASCULAR PRUNING; VASCULAR RING; WESTERN BLOTTING;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, SCID; NEOVASCULARIZATION, PATHOLOGIC; RETINAL DISEASES; TRANSCRIPTOME;

EID: 84863203031     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.064030     Document Type: Article

References (27)

1. Benjamin LE, Hemo I, Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development. 1998; 125:1591-1598. (Pubitemid 28256727)
2. Jain RK. Molecular regulation of vessel maturation. Nat Med. 2003;9: 685-693. (Pubitemid 36749217)
3. Ishida S, Yamashiro K, Usui T, Kaji Y, Ogura Y, Hida T, Honda Y, Oguchi Y, Adamis AP. Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease. Nat Med. 2003;9: 781-788. (Pubitemid 36749230)
4. Obaishi H, Nakanishi H, Mandai K, Satoh K, Satoh A, Takahashi K, Miyahara M, Nishioka H, Takaishi K, Takai Y. Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase. J Biol Chem. 1998;273:18697-18700. (Pubitemid 28366250)
5. Pasteris NG, Nagata K, Hall A, Gorski JL. Isolation, characterization, and mapping of the mouse Fgd3 gene, a new faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologue. Gene. 2000;242:237-247. (Pubitemid 30064509)
6. Pasteris NG, Gorski JL. Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues. Genomics. 1999;60:57-66. (Pubitemid 29422814)
7. Zheng Y, Fischer DJ, Santos MF, Tigyi G, Pasteris NG, Gorski JL, Xu Y. The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hsspecific guanine-nucleotide exchange factor. J Biol Chem. 1996;271: 33169-33172.
8. Pasteris NG, Cadle A, Logie LJ, Porteous ME, Schwartz CE, Stevenson RE, Glover TW, Wilroy RS, Gorski JL. Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor. Cell. 1994;79:669-678.
9. Miyamoto Y, Yamauchi J, Itoh H. Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK. J Biol Chem. 2003;278:29890- 29900. (Pubitemid 36962377)
10. Hayakawa M, Matsushima M, Hagiwara H, Oshima T, Fujino T, Ando K, Kikugawa K, Tanaka H, Miyazawa K, Kitagawa M. Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1. Genes Cells. 2008;13:329-342. (Pubitemid 351437020)
11. Huber C, Martensson A, Bokoch GM, Nemazee D, Gavin AL. FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J Biol Chem. 2008;283:34002-34012.
12. Umikawa M, Obaishi H, Nakanishi H, Satoh-Horikawa K, Takahashi K, Hotta I, Matsuura Y, Takai Y. Association of frabin with the actin cytoskeleton is essential for microspike formation through activation of Cdc42 small G protein. J Biol Chem. 1999;274:25197-25200.
13. Ono Y, Nakanishi H, Nishimura M, Kakizaki M, Takahashi K, Miyahara M, Satoh-Horikawa K, Mandai K, Takai Y. Two actions of frabin: direct activation of Cdc42 and indirect activation of Rac. Oncogene. 2000;19: 3050-3058. (Pubitemid 30438461)
14. Cheng C, Tempel D, Oostlander A, Helderman F, Gijsen F, Wentzel J, van Haperen R, Haitsma DB, Serruys PW, van der Steen AF, de Crom R, Krams R. Rapamycin modulates the eNOS vs. shear stress relationship. Cardiovasc Res. 2008;78:123-129. (Pubitemid 351430952)
15. Cheng C, Tempel D, Den Dekker WK, Haasdijk R, Chrifi I, Bos FL, Wagtmans K, van de Kamp EH, Blonden L, Biessen EA, Moll F, Pasterkamp G, Serruys PW, Schulte-Merker S, Duckers HJ. Ets2 determines the inflammatory state of endothelial cells in advanced atherosclerotic lesions. Circ Res. 109:382-395.
16. Cheng C, Noordeloos AM, Jeney V, Soares MP, Moll F, Pasterkamp G, Serruys PW, Duckers HJ. Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque. Circulation. 2009;119: 3017-3027.
17. Cheng C, Noorderloos M, van Deel ED, Tempel D, den Dekker W, Wagtmans K, Duncker DJ, Soares MP, Laman JD, Duckers HJ. Dendritic cell function in transplantation arteriosclerosis is regulated by heme oxygenase 1. Circ Res. 2010;106:1656-1666.
18. Cheng C, Tempel D, van Haperen R, van Damme L, Algur M, Krams R, de Crom R. Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype. Atherosclerosis. 2009;204: 26-33.
19. Segers D, Helderman F, Cheng C, van Damme LC, Tempel D, Boersma E, Serruys PW, de Crom R, van der Steen AF, Holvoet P, Krams R. Gelatinolytic activity in atherosclerotic plaques is highly localized and is associated with both macrophages and smooth muscle cells in vivo. Circulation. 2007;115:609-616. (Pubitemid 46226171)
20. Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M. The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004;18:901-911. (Pubitemid 38529659)
21. Huang Q, Raya A, DeJesus P, Chao SH, Quon KC, Caldwell JS, Chanda SK, Izpisua-Belmonte JC, Schultz PG. Identification of p53 regulators by genome-wide functional analysis. Proc Natl Acad Sci USA. 2004;101: 3456-3461. (Pubitemid 38338216)
22. Wang L, Yang L, Debidda M, Witte D, Zheng Y. Cdc42 GTPaseactivating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proc Natl Acad Sci USA. 2007;104:1248-1253. (Pubitemid 46183990)
23. Cho KA, Ryu SJ, Oh YS, Park JH, Lee JW, Kim HP, Kim KT, Jang IS, Park SC. Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem. 2004;279:42270-42278. (Pubitemid 39313676)
24. Maillet M, Lynch JM, Sanna B, York AJ, Zheng Y, Molkentin JD. Cdc42 is an antihypertrophic molecular switch in the mouse heart. J Clin Invest. 2009;119:3079-3088.
25. Yang L, Wang L, Geiger H, Cancelas JA, Mo J, Zheng Y. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc Natl Acad Sci USA. 2007;104: 5091-5096. (Pubitemid 47186181)
26. Egorov MV, Capestrano M, Vorontsova OA, Di Pentima A, Egorova AV, Mariggio S, Ayala MI, Tete S, Gorski JL, Luini A, Buccione R, Polishchuk RS. Faciogenital dysplasia protein (FGD1) regulates export of cargo proteins from the Golgi complex via Cdc42 activation. Mol Biol Cell. 2009;20:2413-2427.
27. Kang JS, Bae GU, Yi MJ, Yang YJ, Oh JE, Takaesu G, Zhou YT, Low BC, Krauss RS. A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation. J Cell Biol. 2008;182:497-507.