Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT 1 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4208-4216

  Zhang, Jun ^a   Wang, Jin Liang ^a   Zhou, Zhi Ming ^a   Li, Zhi Huai ^a   Xue, Wei Zhe ^a   Xu, Di ^a   Hao, Li Ping ^a   Han, Xiao Feng ^a   Fei, Fan ^a   Liu, Ting ^b   Liang, Ai Hua ^b  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Angiotensin II AT 1 receptor antagonists; carbamoyl benzimidazole; Hypertension

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CARBAMOYL BENZIMIDAZOLE; LOSARTAN; N (2 METHOXY)BENZYL 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (2 METHOXY)BENZYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (2 METHYL 2 PHENYL)EHTYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (2 PHENYL)PROPYL 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (3 METHOXY)BENZYL 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (3 METHOXY)BENZYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (3,4 DIMETHOXY)BENZYL 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (3,4 DIMETHOXY)BENZYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (4 METHOXY)BENZYL 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (4 METHOXY)BENZYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (BETA PHENETHYL) 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N (BETA PHENETHYL) 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N [BETA (2 FLUORO)PHENETHYL] 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N [BETA (2,5 DIMETHOXY)PHENETHYL] 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N [BETA (2,5 DIMETHOXY)PHENETHYL] 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N [BETA (3 METHOXY)PHENETHYL] 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N [BETA (3 METHOXY)PHENETHYL] 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N [BETA (3,4 DIMETHOXY)PHENETHYL] 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N [BETA (3,4 DIMETHOXY)PHENETHYL] 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N [BETA (4 FLUORO)PHENETHYL] 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N [BETA (4 METHOXY)PHENETHYL] 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N [BETA (4 METHOXY)PHENETHYL] 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N BENZYL 1 [2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; N BENZYL 4 METHYL 2 N PROPYL 1H BENZIMIDAZOLE 6 CARBOXAMIDE; TELMISARTAN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; AORTA STRIP; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISEASE MODEL; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; HYPERTENSION; NONHUMAN; RABBIT; TOXICITY TESTING;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BENZIMIDAZOLES; BIPHENYL COMPOUNDS; BLOOD PRESSURE; DRUG DESIGN; MODELS, MOLECULAR; PROTEIN BINDING; RABBITS; RATS; RATS, INBRED SHR; RECEPTOR, ANGIOTENSIN, TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 84863192222     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.056     Document Type: Article

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