Host susceptibility to tuberculosis: Insights from a longitudinal study of gene expression in diabetes

International Journal of Tuberculosis and Lung Disease

Volumn 16, Issue 3, 2012, Pages 370-372

  Qu, Hui Qi ^a   Rentfro, A R ^b   Lu, Y ^a   Nair, S ^b   Hanis, C L ^a   McCormick, J B ^a   Fisher Hoch, S P ^a  

^a UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF TEXAS AT BROWNSVILLE   (United States)

Author keywords

CD28; HK2; Host susceptibility; Transcriptome; Tuberculosis; Type 2 diabetes

Indexed keywords

GLUCOSE; INSULIN; INTERLEUKIN 12; RNA; T LYMPHOCYTE RECEPTOR;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CD28 GENE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; FEMALE; FOLLOW UP; GENE; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC PREDISPOSITION; GLUCOSE BLOOD LEVEL; GLYCOLYSIS; HEXOKINASE 2 GENE; HOST SUSCEPTIBILITY; HUMAN; INFECTION RISK; INSULIN RESISTANCE; LONGITUDINAL STUDY; MACROPHAGE ACTIVATION; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; TH1 CELL; TRANSCRIPTION REGULATION; TUBERCULOSIS;

ADULT; AGED; ANTIGENS, CD28; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; HEXOKINASE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; TUBERCULOSIS;

EID: 84863182295     PISSN: 10273719     EISSN: None     Source Type: Journal    
DOI: 10.5588/ijtld.11.0536     Document Type: Article

References (10)

1. Dooley K E, Chaisson R E. Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect Dis 2009; 9: 737-746.
2. Jeon C Y, Murray M B. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med 2008; 5: e152.
3. Bailey S L, Grant P. 'The tubercular diabetic': the impact of diabetes mellitus on tuberculosis and its threat to global tuberculosis control. Clin Med 2011; 11: 344-347.
4. Thye T, Vannberg F O, Wong S H, et al. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nat Genet 2010; 42: 739-741.
5. Restrepo B I, Camerlin A J, Rahbar M H, et al. Cross-sectional assessment reveals high diabetes prevalence among newly-diagnosed tuberculosis cases. Bull World Health Organ 2011; 89: 352-359.
6. Cheadle C, Vawter M P, Freed W J, Becker K G. Analysis of microarray data using Z score transformation. J Mol Diagn 2003; 5: 73-81. (Pubitemid 36553428)
7. Berry M P R, Graham C M, McNab F W, et al. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 2010; 466: 973-977.
8. Storey J D. A direct approach to false discovery rates. J R Statist Soc 2002; B, 64: 479-498.
9. Printz R L, Koch S, Potter L R, et al. Hexokinase II mRNA and gene structure, regulation by insulin, and evolution. J Biol Chem 1993; 268: 5209-5219. (Pubitemid 23081650)
10. Alegre M-L, Frauwirth K A, Thompson C B. T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol 2001; 1: 220-228. (Pubitemid 33741960)