LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation

Journal of Pharmacology and Experimental Therapeutics

Volumn 340, Issue 3, 2012, Pages 510-519

  Sun, Xiaoyan ^a,b   Phan, Trong Nhat ^a,b   Jung, Seung Hee ^a   Kim, Sun Young ^c   Cho, Jong Un ^c   Lee, Hyangsook ^c   Woo, Sung Ho ^c   Park, Tae Kyo ^c   Yang, Beom Seok ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c LegoChem Biosciences Inc   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [3 (MORPHOLINOMETHYL)PHENYL]THIENOL[3,2 B]PYRIDIN 7 YLAMINO]PHENOL; AKT1 PROTEIN; ANTIINFLAMMATORY AGENT; COLLAGEN TYPE 1; CYCLOOXYGENASE 2; FOCAL ADHESION KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; LCB 03 0110; PROTEIN SERINE THREONINE KINASE; SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE ACTIVATION; MIGRATION INHIBITION; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SCAR FORMATION; SKIN FIBROBLAST;

AMINOPYRIDINES; ANIMALS; CELLS, CULTURED; CICATRIX; FEMALE; FIBROBLASTS; HUMANS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; RABBITS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, MITOGEN; SRC-FAMILY KINASES; THIOPHENES; WOUND HEALING;

EID: 84863115890     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.187328     Document Type: Article

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