Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 5, 2012, Pages 1455-1460

  Cao, Xuan ^a   Voss, Courtney ^a   Zhao, Bing ^a   Kaneko, Tomonori ^a   Li, Shawn Shun Cheng ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; PROTEIN KINASE; RHO FACTOR; TENSIN;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CELL MIGRATION; CELL TRANSFORMATION; CONFOCAL MICROSCOPY; HUMAN; HUMAN CELL; LIVER CANCER; LIVER CARCINOGENESIS; METASTASIS; PRIORITY JOURNAL; REGULATORY MECHANISM;

ACTINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; FOCAL ADHESIONS; GTPASE-ACTIVATING PROTEINS; HUMANS; MICROFILAMENT PROTEINS; MICROSCOPY, CONFOCAL; TUMOR SUPPRESSOR PROTEINS;

EID: 84863115497     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114368109     Document Type: Article

References (33)

1. Sahai E (2005) Mechanisms of cancer cell invasion. Curr Opin Genet Dev 15:87-96.
2. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279:509-514.
3. Wennerberg K, Der CJ (2004) Rho-family GTPases: It's not only Rac and Rho (and I like it). J Cell Sci 117:1301-1312. (Pubitemid 38559808)
4. Durkin ME, et al. (2007) DLC-1: A Rho GTPase-activating protein and tumour suppressor. J Cell Mol Med 11:1185-1207. (Pubitemid 350037059)
5. Yuan BZ, Durkin ME, Popescu NC (2003) Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers. Cancer Genet Cytogenet 140:113-117. (Pubitemid 36349010)
6. Wong CM, Lee JM, Ching YP, Jin DY, Ng IO (2003) Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma. Cancer Res 63:7646-7651. (Pubitemid 37466690)
7. Goodison S, et al. (2005) The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells. Cancer Res 65:6042-6053. (Pubitemid 40994388)
8. Zhou X, Thorgeirsson SS, Popescu NC (2004) Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells. Oncogene 23:1308-1313. (Pubitemid 38297186)
9. Healy KD, et al. (2008) DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog 47:326-337. (Pubitemid 351614573)
10. Xue W, et al. (2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes Dev 22:1439-1444. (Pubitemid 351793078)
11. Qiao F, Bowie JU (2005) The many faces of SAM. Sci STKE 2005:re7.
12. Moon SY, Zheng Y (2003) Rho GTPase-activating proteins in cell regulation. Trends Cell Biol 13:13-22. (Pubitemid 35453891)
13. Ponting CP, Aravind L (1999) START: A lipid-binding domain in StAR, HD-ZIP and signalling proteins. Trends Biochem Sci 24:130-132. (Pubitemid 29222709)
14. Qian X, et al. (2007) Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci USA 104:9012-9017. (Pubitemid 47175428)
15. Liao YC, Si L, de Vere White RW, Lo SH (2007) The phosphotyrosine- independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. J Cell Biol 176:43-49. (Pubitemid 46041679)
16. Yam JW, Ko FC, Chan CY, Jin DY, Ng IO (2006) Interaction of deleted in liver cancer 1with tensin2 in caveolae and implications in tumor suppression. Cancer Res 66:8367-8372. (Pubitemid 44449146)
17. Lo SH (2004) Tensin. Int J Biochem Cell Biol 36:31-34.
18. Sasaki H, et al. (2003) Cten mRNA expression was correlated with tumor progression in lung cancers. Lung Cancer 40:151-155. (Pubitemid 36438715)
19. Lo SH, Lo TB (2002) Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. Cancer Res 62:4217-4221. (Pubitemid 34827275)
20. Sasaki H, Yukiue H, Kobayashi Y, Fukai I, Fujii Y (2003) Cten mRNA expression is correlated with tumor progression in thymoma. Tumour Biol 24:271-274. (Pubitemid 38316497)
21. Martuszewska D, et al. (2009) Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer. PLoS One 4:e4350.
22. Katz M, et al. (2007) A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. Nat Cell Biol 9:961-969. (Pubitemid 47190451)
23. Hall EH, Daugherty AE, Choi CK, Horwitz AF, Brautigan DL (2009) Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. J Biol Chem 284:34713-34722.
24. Hynes NE, MacDonald G (2009) ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol 21:177-184.
25. Kim TY, et al. (2008) Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration. J Biol Chem 283:32762-32770.
26. Wong CC, et al. (2008) Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma. PLoS One 3:e2779.
27. Qian Y, et al. (2005) ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene 24:3154-3165. (Pubitemid 40695084)
28. Sabates-Bellver J, et al. (2007) Transcriptome profile of human colorectal adenomas. Mol Cancer Res 5:1263-1275.
29. Finak G, et al. (2008) Stromal gene expression predicts clinical outcome in breast cancer. Nat Med 14:518-527. (Pubitemid 351655218)
30. Xia W, et al. (2002) Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene 21:6255-6263.
31. Kim TY, Vigil D, Der CJ, Juliano RL (2009) Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility. Cancer Metastasis Rev 28:77-83.
32. Burridge K, Wennerberg K (2004) Rho and Rac take center stage. Cell 116:167-179. (Pubitemid 38167310)
33. Etienne-Manneville S, Hall A (2002) Rho GTPases in cell biology. Nature 420:629-635. (Pubitemid 36764489)