RPA and POT1: Friends or foes at telomeres?

Cell Cycle

Volumn 11, Issue 4, 2012, Pages 652-657

  Flynn, Rachel Litman ^a   Chang, Sandy ^c   Zou, Lee ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ATR; Checkpoint; POT1; RPA; Telomere

Indexed keywords

DOUBLE STRANDED DNA; MEMBRANE PROTEIN; PROTECTION OF TELOMERE 1; REPLICATION FACTOR A; RNA; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

CELL CYCLE; CELL CYCLE REGULATION; DNA REPLICATION; DNA SEQUENCE; DOUBLE STRANDED DNA BREAK; HUMAN; NONHUMAN; PROTEIN BINDING; REVIEW; TELOMERE;

ATAXIA TELANGIECTASIA;

EID: 84863115263     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.11.4.19061     Document Type: Review

References (50)

1. Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E, Lingner J. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 2007; 318:798-801; PMID:17916692; http://dx.doi.org/10.1126/science. 1147182.
2. Schoeftner S, Blasco MA. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat Cell Biol 2008; 10:228-36; PMID:18157120; http://dx.doi.org/10.1038/ncb1685.
3. Palm W, de Lange T. How shelterin protects mammalian telomeres. Annu Rev Genet 2008; 42:301-34; PMID:18680434; http://dx.doi.org/10.1146/annurev.genet. 41.110306.130350.
4. Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis 2010; 31:9-18; PMID:19887512; http://dx.doi.org/10.1093/carcin/ bgp268.
5. Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, et al. Mammalian telomeres end in a large duplex loop. Cell 1999; 97:503-14; PMID:10338214; http://dx.doi.org/10.1016/S0092-8674(00)80760-6.
6. Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, et al. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 2007; 445:506-10; PMID:17237768; http://dx.doi.org/10.1038/nature05454.
7. Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 2001; 292:1171-5; PMID:11349150; http://dx.doi.org/10.1126/science.1060036.
8. Xin H, Liu D, Wan M, Safari A, Kim H, Sun W, et al. TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature 2007; 445:559-62; PMID:17237767; http://dx.doi.org/10.1038/nature05469.
9. Hockemeyer D, Daniels JP, Takai H, de Lange T. Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell 2006; 126:63-77; PMID:16839877; http://dx.doi.org/10.1016/j. cell.2006.04.044.
10. Wu L, Multani AS, He H, Cosme-Blanco W, Deng Y, Deng JM, et al. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 2006; 126:49-62; PMID:16839876; http://dx.doi.org/10.1016/j.cell.2006.05.037.
11. He H, Multani AS, Cosme-Blanco W, Tahara H, Ma J, Pathak S, et al. POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J 2006; 25:5180-90; PMID:17053789; http://dx.doi.org/10. 1038/sj.emboj.7601294.
12. Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, et al. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem 2004; 279:47264-71; PMID:15316005; http://dx.doi.org/10. 1074/jbc.M409047200.
13. Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, et al. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev 2004; 18:1649-54; PMID:15231715; http://dx.doi.org/10.1101/gad.1215404.
14. Shiotani B, Zou L. Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell 2009; 33:547-58; PMID:19285939; http://dx.doi.org/10. 1016/j.molcel.2009.01.024.
15. Flynn RL, Zou L. ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci 2011; 36:133-40; PMID:20947357; http://dx.doi.org/10.1016/j.tibs.2010.09.005.
16. Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003; 300:1542-8; PMID:12791985; http://dx.doi.org/10.1126/science.1083430.
17. Denchi EL, de Lange T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 2007; 448:1068-71; PMID:17687332; http://dx.doi.org/10.1038/nature06065.
18. Guo X, Deng Y, Lin Y, Cosme-Blanco W, Chan S, He H, et al. Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J 2007; 26:4709-19; PMID:17948054; http://dx.doi.org/10. 1038/sj.emboj.7601893.
19. Gong Y, de Lange TA. A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol Cell 2010; 40:377-87; PMID:21070964; http://dx.doi.org/10.1016/j.molcel.2010.10.016.
20. Barrientos KS, Kendellen MF, Freibaum BD, Armbruster BN, Etheridge KT, Counter CM. Distinct functions of POT1 at telomeres. Mol Cell Biol 2008; 28:5251-64; PMID:18519588; http://dx.doi.org/10.1128/MCB.00048-08.
21. Flynn RL, Centore RC, O'Sullivan RJ, Rai R, Tse A, Songyang Z, et al. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature 2011; 471:532-6; PMID:21399625; http://dx.doi.org/10.1038/ nature09772.
22. Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T. Telomere protection by TPP1/POT1 requires tethering to TIN2. Mol Cell 2011; 44:647-59; PMID:22099311; http://dx.doi.org/10.1016/j.molcel.2011.08.043.
23. Seroussi E, Lavi S. Replication protein A is the major single-stranded DNA binding protein detected in mammalian cell extracts by gel retardation assays and UV cross-linking of long and short single-stranded DNA molecules. J Biol Chem 1993; 268:7147-54; PMID:8463251.
24. Kenny MK, Schlegel U, Furneaux H, Hurwitz J. The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication. J Biol Chem 1990; 265:7693-700; PMID:2159011.
25. Takai KK, Hooper S, Blackwood S, Gandhi R, de Lange T. In vivo stoichiometry of shelterin components. J Biol Chem 2010; 285:1457-67; PMID:19864690; http://dx.doi.org/10.1074/jbc.M109.038026.
26. Wold MS. Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu Rev Biochem 1997; 66:61-92; PMID:9242902; http://dx.doi.org/10.1146/annurev.biochem.66.1.61.
27. Fanning E, Klimovich V, Nager AR. A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res 2006; 34:4126-37; PMID:16935876; http://dx.doi.org/10.1093/nar/gkl550.
28. Déjardin J, Kingston RE. Purification of proteins associated with specific genomic Loci. Cell 2009; 136:175-86; PMID:19135898; http://dx.doi.org/10.1016/j.cell.2008.11.045.
29. Verdun RE, Karlseder J. Replication and protection of telomeres. Nature 2007; 447:924-31; PMID:17581575; http://dx.doi.org/10.1038/nature05976.
30. Moser BA, Subramanian L, Chang YT, Noguchi C, Noguchi E, Nakamura TM. Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres. EMBO J 2009; 28:810-20; PMID:19214192; http://dx.doi.org/10. 1038/emboj.2009.31.
31. McGee JS, Phillips JA, Chan A, Sabourin M, Paeschke K, Zakian VA. Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair. Nat Struct Mol Biol 2010; 17:1438-45; PMID:21057524; http://dx.doi.org/10.1038/nsmb.1947.
32. Smith J, Zou H, Rothstein R. Characterization of genetic interactions with RFA1: the role of RPA in DNA replication and telomere maintenance. Biochimie 2000; 82:71-8; PMID:10717390; http://dx.doi.org/10.1016/S0300-9084(00) 00183-8.
33. Ono Y, Tomita K, Matsuura A, Nakagawa T, Masukata H, Uritani M, et al. A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation. Nucleic Acids Res 2003; 31:7141-9; PMID:14654689; http://dx.doi.org/10.1093/nar/gkg917.
34. Schramke V, Luciano P, Brevet V, Guillot S, Corda Y, Longhese MP, et al. RPA regulates telomerase action by providing Est1p access to chromosome ends. Nat Genet 2004; 36:46-54; PMID:14702040; http://dx.doi.org/10.1038/ng1284.
35. Kibe T, Ono Y, Sato K, Ueno M. Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss. Mol Biol Cell 2007; 18:2378-87; PMID:17429064; http://dx.doi.org/10.1091/mbc.E06-12-1084.
36. Chen C, Umezu K, Kolodner RD. Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair. Mol Cell 1998; 2:9-22; PMID:9702187; http://dx.doi.org/10.1016/S1097-2765(00)80109-4.
37. 2 of the cell cycle. Mol Cell 2005; 20:551-61; PMID:16307919; http://dx.doi.org/10.1016/j.molcel.2005.09.024.
38. McNees CJ, Tejera AM, Martínez P, Murga M, Mulero F, Fernandez-Capetillo O, et al. ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase. J Cell Biol 2010; 188:639-52; PMID:20212315; http://dx.doi.org/10. 1083/jcb.200908136.
39. Lei M, Podell ER, Cech TR. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat Struct Mol Biol 2004; 11:1223-9; PMID:15558049; http://dx.doi.org/10.1038/nsmb867.
40. Loayza D, Parsons H, Donigian J, Hoke K, de Lange T. DNA binding features of human POT1: a nonamer 5′-TAG GGT TAG-3′ minimal binding site, sequence specificity and internal binding to multimeric sites. J Biol Chem 2004; 279:13241-8; PMID:14715659; http://dx.doi.org/10.1074/jbc.M312309200.
41. Loayza D, De Lange T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 2003; 423:1013-8; PMID:12768206; http://dx.doi.org/10. 1038/nature01688.
42. Palm W, Hockemeyer D, Kibe T, de Lange T. Functional dissection of human and mouse POT1 proteins. Mol Cell Biol 2009; 29:471-82; PMID:18955498; http://dx.doi.org/10.1128/MCB.01352-08.
43. Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, et al. Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nat Struct Mol Biol 2007; 14:754-61; PMID:17632522; http://dx.doi.org/10.1038/nsmb1270.
44. Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, et al. PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol 2004; 6:673-80; PMID:15181449; http://dx.doi.org/10.1038/ncb1142.
45. McKay SJ, Cooke H. hnRNP A2/B1 binds specifically to single stranded vertebrate telomeric repeat TTA GGGn. Nucleic Acids Res 1992; 20:6461-4; PMID:1282701; http://dx.doi.org/10.1093/nar/20.24.6461.
46. Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR. Nuclear proteins that bind the pre-mRNA 3′ splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTA GGG)n. Mol Cell Biol 1993; 13:4301-10; PMID:8321232.
47. LaBranche H, Dupuis S, Ben-David Y, Bani MR, Wellinger RJ, Chabot B. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nat Genet 1998; 19:199-202; PMID:9620782; http://dx.doi.org/10.1038/575.
48. Zhang QS, Manche L, Xu RM, Krainer AR. hnRNP A1 associates with telomere ends and stimulates telomerase activity. RNA 2006; 12:1116-28; PMID:16603717; http://dx.doi.org/10.1261/rna.58806.
49. Porro A, Feuerhahn S, Reichenbach P, Lingner J. Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways. Mol Cell Biol 2010; 30:4808-17; PMID:20713443; http://dx.doi.org/10.1128/MCB.00460-10.
50. Wei C, Price CM. Cell cycle localization, dimerization and binding domain architecture of the telomere protein cPot1. Mol Cell Biol 2004; 24:2091-102; PMID:14966288; http://dx.doi.org/10.1128/MCB.24.5.2091-102.2004.