Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 12, 2012, Pages 5774-5783

  Kapanda, Coco N ^a   Masquelier, Julien ^a   Labar, Geoffray ^a   Muccioli, Giulio G ^a   Poupaert, Jacques H ^a   Lambert, Didier M ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 BENZHYDRYLPIPERAZIN 1 YL) 1 PHENYL 2 THIOXOETHANONE; 2,4 DINITROPHENYL 4 (4 TERT BUTYLBENZYL)PIPERAZINE 1 CARBODITHIOATE; 2,4 DINITROPHENYL 4 BENZHYDRYLPIPERAZINE 1 CARBODITHIOATE; 4 BENZHYDRYL N PHENYLPIPERAZINE 1 CARBOTHIOAMIDE; ACYLGLYCEROL LIPASE; CAY 10499; DIMETHYL SULFOXIDE; DISULFIRAM; DITHIOCARBAMIC ACID DERIVATIVE; ESTERASE INHIBITOR; JZL 184; MONOACYLGLYCEROL LIPASE INHIBITOR; PHENYL 4 BENZHYDRYLPIPERAZINE 1 CARBODITHIOATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; SUBSTITUTION REACTION;

ANIMALS; CARBAMATES; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DISULFIDES; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MONOACYLGLYCEROL LIPASES; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

EID: 84863110189     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3006004     Document Type: Article

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