MMP-15 is upregulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Kaitu'u Lino, Tu'uhevaha J ^a   Palmer, Kirsten ^a   Tuohey, Laura ^a   Ye, Louie ^a   Tong, Stephen ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOGLIN; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; SMALL INTERFERING RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PLACENTA; PREECLAMPSIA; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; SYNCYTIOTROPHOBLAST;

ADULT; ANTIGENS, CD; COHORT STUDIES; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MATRIX METALLOPROTEINASE 15; PRE-ECLAMPSIA; PREGNANCY; PROTEIN TRANSPORT; RECEPTORS, CELL SURFACE; SOLUBILITY; TROPHOBLASTS; UP-REGULATION;

EID: 84863105919     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039864     Document Type: Article

References (25)

1. Powe CE, Levine RJ, Karumanchi SA, (2011) Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation 123: 2856-2869.
2. Sibai B, Dekker G, Kupferminc M, (2005) Pre-eclampsia. Lancet 365: 785-799.
3. Maynard S, Min JY, Merchan J, Lim KH, Li J, et al. (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt-1) may contribute to endothelial dysfunction, hypertension, and proteinuria in pre-eclampsia. The Journal of Clinical Investigation 111: 649-658.
4. Maynard SE, Karumanchi SA, (2011) Angiogenic factors and preeclampsia. Semin Nephrol 31: 33-46.
5. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, et al. (2006) Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 12: 642-649.
6. Gougos A, St Jacques S, Greaves A, O'Connell PJ, d'Apice AJ, et al. (1992) Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblasts. Int Immunol 4: 83-92.
7. Devy L, Huang L, Naa L, Yanamandra N, Pieters H, et al. (2009) Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. Cancer Res 69: 1517-1526.
8. Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, et al. (2011) Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors. Cancer Res 71: 4527-4538.
9. Rozanov DV, Savinov AY, Williams R, Liu K, Golubkov VS, et al. (2008) Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer. Cancer Res 68: 4086-4096.
10. Sabbota AL, Kim HR, Zhe X, Fridman R, Bonfil RD, et al. (2010) Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration. Cancer Res 70: 5558-5566.
11. Hawinkels LJ, Kuiper P, Wiercinska E, Verspaget HW, Liu Z, et al. (2010) Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer Res 70: 4141-4150.
12. Kaitu'u-Lino TJ, Palmer KR, Whitehead CL, Williams E, Lappas M, et al. (2012) MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin. Am J Pathol In press.
13. Takino T, Sato H, Shinagawa A, Seiki M, (1995) Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. J Biol Chem 270: 23013-23020.
14. BioGPS (2012) Gene Portal System. BioGPS.org, eds. editor.
15. Szabova L, Son MY, Shi J, Sramko M, Yamada SS, et al. (2011) Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood 116: 5752-5761.
16. ACOG (2002) Diagnosis and Management of Pre-eclampsia and Eclampsia. ACOG Practice Bulletin No. 33. Obstet Gynecol 99: 159-167.
17. Bjorn SF, Hastrup N, Larsen JF, Lund LR, Pyke C, (2000) Messenger RNA for membrane-type 2 matrix metalloproteinase, MT2-MMP, is expressed in human placenta of first trimester. Placenta 21: 170-176.
18. Bar-Or A, Nuttall RK, Duddy M, Alter A, Kim HJ, et al. (2003) Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain 126: 2738-2749.
19. Lafleur MA, Handsley MM, Knauper V, Murphy G, Edwards DR, (2002) Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs). J Cell Sci 115: 3427-3438.
20. Theret N, Musso O, L'Helgoualc'h A, Campion JP, Clement B, (1998) Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers. Am J Pathol 153: 945-954.
21. d'Ortho MP, Will H, Atkinson S, Butler G, Messent A, et al. (1997) Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases. Eur J Biochem 250: 751-757.
22. Nakada M, Nakamura H, Ikeda E, Fujimoto N, Yamashita J, et al. (1999) Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human astrocytic tumors. Am J Pathol 154: 417-428.
23. Ohnishi Y, Tajima S, Ishibashi A, (2001) Coordinate expression of membrane type-matrix metalloproteinases-2 and 3 (MT2-MMP and MT3-MMP) and matrix metalloproteinase-2 (MMP-2) in primary and metastatic melanoma cells. Eur J Dermatol 11: 420-423.
24. Sato H, Okada Y, Seiki M, (1997) Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion. Thromb Haemost 78: 497-500.
25. Myers JE, Merchant SJ, Macleod M, Mires GJ, Baker PN, et al. (2005) MMP-2 levels are elevated in the plasma of women who subsequently develop preeclampsia. Hypertens Pregnancy 24: 103-115.