Expression of UBE2Q2, a putative member of the Ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia

Archives of Iranian Medicine

Volumn 15, Issue 6, 2012, Pages 352-355

  Seghatoleslam, Atefeh ^a   Monabbati, Ahmad ^a   Bozorg Ghalati, Farzaneh ^a   Nikseresht, Mohsen ^b   Bordbar, Mohammad Reza ^a   Rahvar, Mostafa ^a   Owji, Ali Akbar ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b YASUJ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute lymphoblastic leukemia; Real time PCR; UBE2Q2; Ubiquitin conjugating enzyme

Indexed keywords

MESSENGER RNA; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; BLOOD CELL; BLOOD SAMPLING; BONE MARROW; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; LEUKEMOGENESIS; MOLECULAR DIAGNOSIS; PRESCHOOL CHILD; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UBE2Q2 GENE;

ADOLESCENT; BONE MARROW; CHILD; CHILD, PRESCHOOL; CYTOSKELETAL PROTEINS; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UBIQUITIN-CONJUGATING ENZYMES;

EID: 84863094901     PISSN: 10292977     EISSN: 17353947     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Lichtman M, Beutler E, Kipps T, Seligsohn U, Kaushansky K. Acute Lymphoblastic Leukemia. Malignant diseases. In: Lichtman MA, Williams WJ, eds. Williams Hematology, 7th ed. Part IX. Chapter 91. New York: McGraw-Hill; 2007: 1321-1325.
2. Nandi D, Tahiliani P, Kumar A, Chandu D. The ubiquitin-proteasome system. J Biosci. 2006; 31: 137-155.
3. Hershko A. The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle. Cell Death Differ. 2005; 12: 1191-1197.
4. Vodermaier HC. APC/C and SCF: controlling each other and the cell cycle. Curr Biol. 2004; 14: R787-R796.
5. Schwartz AL, Ciechanover A. Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. Annu Rev Pharmacol Toxicol. 2009; 49: 73-96.
6. Schwartz AL, Ciechanover A. The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med. 1999; 50: 57-74.
7. Lipkowitz S. The role of the ubiquitination-proteasome pathway in breast cancer: ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer. Breast Cancer Res. 2003; 5: 8-15.
8. Ieta K, Ojima E, Tanaka F, Nakamura Y, Haraguchi N, Mimori K, et al. Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. Int J Cancer. 2007; 121: 33-38.
9. Eliseeva E, Pati D, Diccinanni MB, Yu AL, Mohsin SK, Margolin JF, et al. Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia. Cell Growth Differ. 2001; 12: 427-433.
10. Cromer A, Carles A, Millon R, Ganguli G, Chalmel F, Lemaire F, et al. Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis. Oncogene. 2004; 23: 2484-2498.
11. Lemaire F, Millon R, Young J, Cromer A, Wasylyk C, Schultz I, et al. Differential expression profiling of head and neck squamous cell carcinoma (HNSCC). Br J Cancer. 2003; 89: 1940-1949.
12. Seghatoleslam A, Zambrano A, Millon R, Ganguli G, Argentini M, Cromer A, et al. Analysis of a novel human gene, LOC92912, overexpressed in hypopharyngeal tumors. Biochem Biophys Res Commun. 2006; 339: 422-429.
13. Nikseresht M, Seghatoleslam A, Monabati A, Talei A, Bozorg Ghalati F, Owji AA. Over expression of the novel human gene, UBE2Q2, in breast cancer. Cancer Genetic cytogenet. 2010; 197: 101-106.
14. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001; 29: e45.
15. Seghatoleslam A, Zambrano A. Novel human gene, LOC92912, alters cell cycle progression in cultured cells. Iran J Med Sci. 2009; 34: 277-284.
16. Shimbara N, Sato C, Takashima M, Tanaka T, Tanaka K, Ichihara A. Downregulation of ubiquitin gene expression during differentiation of himan leukemia cells. fEbS Lett. 1993; 322: 235-239.
17. Gu H, Roizman B. The degradation of promyelocytic leukemia and Sp 100 proteins by herpes simplex virus 1 is mediated by the ubiqutincojugating enzyme UbcH5a. Proc Natl Acad Sci U S A. 2003; 100: 8963-8968.
18. Gez S, Crossett B, Christopherson RI. Differentially expressed cytosolic proteins in human leukemia and lymphoma cell lines correlate with lineages and functions. Biochim Biophys Acta. 2007; 1774: 1173-118319.
19. Buchwald M, Pietschmann K, Müller JP, Böhmer FD, Heinzel T, Krämer OH. Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation. Leukemia. 2010; 24: 1412-1421.
20. Flotho C, Coustan-Smith E, Pei D, Cheng C, Song G, Pui CH, et al. A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia. Blood. 2007; 110: 1271-1277.
21. Winter SS, Jiang Z, Khawaja HM, Griffin T, Devidas M, Asselin BL, et al. Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia. Blood. 2007; 110: 1429-1438.
22. Bhojwani D, Kang H, Menezes RX, Yang W, Sather H, Moskowitz NP, et al. Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: a Children's Oncology Group Study. J Clin Oncol. 2008; 26: 4376-4384.
23. Cortez MA, Scrideli CA, Yunes JA, Valera ET, Toledo SR, Pavoni-Ferreira PC, et al. mRNA expression profile of multidrug resistance genes in childhood acute lymphoblastic leukemia. Low expression levels associated with a higher risk of toxic death. Pediatr Blood Cancer. 2009; 53: 996-1004.
24. Melner MH, Ducharme NA, Brash AR, Winfrey VP, Olson GE. Differential expression of genes in the endometrium at implanttation: upregulation of a novel member of the E2 class of ubiquitin-conjugating enzymes. Biol Reprod. 2004; 70: 406-414.