Mirroring everyday clinical practice in clinical trial design: A new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression

BMC Medicine

Volumn 10, Issue , 2012, Pages

  Severus, Emanuel ^a,b   Seemüller, Florian ^b   Berger, Michael ^b   Dittmann, Sandra ^b   Obermeier, Michael ^b   Pfennig, Andrea ^a   Riedel, Michael ^b,c   Frangou, Sophia ^d   Möller, Hans Jürgen ^b   Bauer, Michael ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c Vinzenz von Paul Hospital   (Germany)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Clinical trials; Major depression; Psychopharmacology; Randomized controlled trials

Indexed keywords

ANTIDEPRESSANT AGENT; PLACEBO;

ARTICLE; CLINICAL FEATURE; CLINICAL PRACTICE; CONTROLLED STUDY; DEMOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; HUMAN; MAJOR DEPRESSION; RANDOMIZED CONTROLLED TRIAL; STUDY DESIGN; TREATMENT OUTCOME; DEPRESSIVE DISORDER, MAJOR; MALE; METHODOLOGY; PLACEBO EFFECT; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPRODUCIBILITY;

ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER, MAJOR; DOUBLE-BLIND METHOD; HUMANS; MALE; PLACEBO EFFECT; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; TREATMENT OUTCOME;

EID: 84863090407     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-10-67     Document Type: Article

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