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Volumn 6, Issue 1, 2012, Pages 61-69

The effect of intravitreal anti-VEGF agents on peripheral wound healing in a rabbit model

Author keywords

Anti VEGF; Bevacizumab; Intraocular; Pegaptanib; Ranibizumab; Wound healing

Indexed keywords

BEVACIZUMAB; CD34 ANTIBODY; EOSIN; HEMATOXYLIN; PEGAPTANIB; PLACEBO; RANIBIZUMAB;

EID: 84863078521     PISSN: 11775467     EISSN: 11775483     Source Type: Journal    
DOI: 10.2147/OPTH.S28275     Document Type: Article
Times cited : (9)

References (47)
  • 1
    • 11144354339 scopus 로고    scopus 로고
    • Prevalence of age-related macular degeneration in the United States
    • For the Eye Diseases Prevalence Research Group
    • Friedman DS, O'Colmain BJ, Muños T, et al; For the Eye Diseases Prevalence Research Group. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004;122:564-572.
    • (2004) Arch Ophthalmol , vol.122 , pp. 564-572
    • Friedman, D.S.1    O'Colmain, B.J.2    Muños, T.3
  • 2
    • 75149172639 scopus 로고    scopus 로고
    • The prevalence of retinal vein occlusion: Pooled data from population studies from the United States, Europe, Asia, and Australia
    • For the International Eye Disease Consortium
    • Rogers S, McIntosh RL, Cheung N, et al; For the International Eye Disease Consortium. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology. 2010;117(2):313-319.
    • (2010) Ophthalmology , vol.117 , Issue.2 , pp. 313-319
    • Rogers, S.1    McIntosh, R.L.2    Cheung, N.3
  • 3
    • 13244277956 scopus 로고    scopus 로고
    • New therapy for central retinal vein occlusion: Are intravitreal steroids a possible answer?
    • Blumenkranz MS. New therapy for central retinal vein occlusion: are intravitreal steroids a possible answer? Arch Ophthalmol. 2005;123:259-261.
    • (2005) Arch Ophthalmol , vol.123 , pp. 259-261
    • Blumenkranz, M.S.1
  • 4
    • 11144356305 scopus 로고    scopus 로고
    • For the Eye Diseases Prevalence Research Group: The prevalence of diabetic retinopathy among adults in the United States
    • Kempen JH, O'Colmain, Leske MC, et al; For the Eye Diseases Prevalence Research Group: The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol. 2004;122:552-563.
    • (2004) Arch Ophthalmol , vol.122 , pp. 552-563
    • Kempen, J.H.1    O'Colmain, L.M.C.2
  • 5
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med. 2003;359(5):427-434.
    • (2003) N Engl J Med , vol.359 , Issue.5 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 6
    • 37349055147 scopus 로고    scopus 로고
    • High frequency of intracerebral hemorrhage in metastatic renal carcinoma patients with brain metastases treated with tyrosine kinase inhibitors targeting the vascular endothelial growth factor receptor
    • Pouessel D, Culine S. High frequency of intracerebral hemorrhage in metastatic renal carcinoma patients with brain metastases treated with tyrosine kinase inhibitors targeting the vascular endothelial growth factor receptor. Eur Urol. 2008;53(2):376-381.
    • (2008) Eur Urol , vol.53 , Issue.2 , pp. 376-381
    • Pouessel, D.1    Culine, S.2
  • 7
    • 57349189269 scopus 로고    scopus 로고
    • Final efficacy results for bevacizumab plus standard first-line chemotherapies in patients with metastatic colorectal cancer: First BEAT
    • abstract 4025
    • Berry SR, Van Cutsem E, Kretzschmar A, et al. Final efficacy results for bevacizumab plus standard first-line chemotherapies in patients with metastatic colorectal cancer: first BEAT. J Clin Oncol. 2008; 26(Suppl 15):abstract 4025.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. 15
    • Berry, S.R.1    van Cutsem, E.2    Kretzschmar, A.3
  • 8
    • 65549122619 scopus 로고    scopus 로고
    • Management of hypertension in angiogenesis inhibitor-treated patients
    • Izzedine H, Ederhy S, Goldwasser F, et al. Management of hypertension in angiogenesis inhibitor-treated patients. Ann Oncol. 2009;20:807-815.
    • (2009) Ann Oncol , vol.20 , pp. 807-815
    • Izzedine, H.1    Ederhy, S.2    Goldwasser, F.3
  • 9
    • 33846638744 scopus 로고    scopus 로고
    • Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor; systematic review and meta-analysis
    • Zhu X, Wu S, Dahut WL, Parikh CR. Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor; systematic review and meta-analysis. Am J Kidney Dis. 2007;49(2):186-193.
    • (2007) Am J Kidney Dis , vol.49 , Issue.2 , pp. 186-193
    • Zhu, X.1    Wu, S.2    Dahut, W.L.3    Parikh, C.R.4
  • 10
    • 17844373871 scopus 로고    scopus 로고
    • Thromboembolic events in gastric cancer: High incidence in patients receiving irinotecan- and bevacizumabbased therapy
    • Shah MA, Ilson D, Kelsen DP. Thromboembolic events in gastric cancer: high incidence in patients receiving irinotecan- and bevacizumabbased therapy. J Clin Oncol. 2005;23(11):2574-2576.
    • (2005) J Clin Oncol , vol.23 , Issue.11 , pp. 2574-2576
    • Shah, M.A.1    Ilson, D.2    Kelsen, D.P.3
  • 11
    • 62949129110 scopus 로고    scopus 로고
    • Intricacies of bevacizumab-induced toxicities and their management
    • Gressett SM, Shah SR. Intricacies of bevacizumab-induced toxicities and their management. Ann Pharmacother. 2009;43(3):490-501.
    • (2009) Ann Pharmacother , vol.43 , Issue.3 , pp. 490-501
    • Gressett, S.M.1    Shah, S.R.2
  • 12
    • 34247616833 scopus 로고    scopus 로고
    • Bronchoscopy for bevacizumab-related hemoptysis
    • Cho YJ, Septimiu DM, Colt HG. Bronchoscopy for bevacizumab-related hemoptysis. Lung Cancer. 2007;56:465-468.
    • (2007) Lung Cancer , vol.56 , pp. 465-468
    • Cho, Y.J.1    Septimiu, D.M.2    Colt, H.G.3
  • 13
    • 33645362726 scopus 로고    scopus 로고
    • Increased risk of ischemic bowel complications during treatment with bevacizumab after pelvic irradiation: Report of three cases
    • Lordick F, Neinitz H, Thelsen J, Sendler A, Sarbia M. Increased risk of ischemic bowel complications during treatment with bevacizumab after pelvic irradiation: report of three cases. Int J Radiat Oncol Biol Phys. 2006;64(5):1295-1298.
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , Issue.5 , pp. 1295-1298
    • Lordick, F.1    Neinitz, H.2    Thelsen, J.3    Sendler, A.4    Sarbia, M.5
  • 14
    • 33750558062 scopus 로고    scopus 로고
    • Skin rash secondary to bevacizumab in a patient with advanced colorectal cancer and relation to response
    • Totlib V, Khaled S, Lapko I, Mar N, Saif MW. Skin rash secondary to bevacizumab in a patient with advanced colorectal cancer and relation to response. Anticancer Drugs. 2006;17(10):1227-1229.
    • (2006) Anticancer Drugs , vol.17 , Issue.10 , pp. 1227-1229
    • Totlib, V.1    Khaled, S.2    Lapko, I.3    Mar, N.4    Saif, M.W.5
  • 15
    • 66149138006 scopus 로고    scopus 로고
    • A review on bevacizumab and surgical wound healing: An important warning to all surgeons
    • Gordon CR, Rojavin Y, Patel M, et al. A review on bevacizumab and surgical wound healing: an important warning to all surgeons. Ann Plast Surg. 2009;62(6):707-709.
    • (2009) Ann Plast Surg , vol.62 , Issue.6 , pp. 707-709
    • Gordon, C.R.1    Rojavin, Y.2    Patel, M.3
  • 16
    • 64849086646 scopus 로고    scopus 로고
    • Wound dehiscence or failure to heal following venous access port placement in patients receiving bevacizumab therapy
    • Zawacki WJ, Walker TG, DeVasher E, et al. Wound dehiscence or failure to heal following venous access port placement in patients receiving bevacizumab therapy. J Vasc Interv Radiol. 2009;20(5):624-627.
    • (2009) J Vasc Interv Radiol , vol.20 , Issue.5 , pp. 624-627
    • Zawacki, W.J.1    Walker, T.G.2    Devasher, E.3
  • 17
    • 33845433384 scopus 로고    scopus 로고
    • Angiogenesis inhibition with bevacizumab and the surgical management of colorectal cancer
    • Thornton AD, Ravn P, Winslet M, Chester K. Angiogenesis inhibition with bevacizumab and the surgical management of colorectal cancer. Br J Surg. 2006;93(12):1456-1463.
    • (2006) Br J Surg , vol.93 , Issue.12 , pp. 1456-1463
    • Thornton, A.D.1    Ravn, P.2    Winslet, M.3    Chester, K.4
  • 18
    • 24344442899 scopus 로고    scopus 로고
    • Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab
    • Scappaticci FA, Fehrenbacher L, Cartwright T, et al. Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab. J Surg Oncol. 2005;91(3):173-180.
    • (2005) J Surg Oncol , vol.91 , Issue.3 , pp. 173-180
    • Scappaticci, F.A.1    Fehrenbacher, L.2    Cartwright, T.3
  • 19
    • 66149147757 scopus 로고    scopus 로고
    • Initial Safety Report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer (BEAT)
    • Allegra CJ, Yothers G, O'Connell MJ, et al. Initial Safety Report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer (BEAT). J Clinic Oncol. 2009;27:3385-3390.
    • (2009) J Clinic Oncol , vol.27 , pp. 3385-3390
    • Allegra, C.J.1    Yothers, G.2    O'Connell, M.J.3
  • 20
    • 77950339501 scopus 로고    scopus 로고
    • Vascular endothelial growth factor targeted therapy in the perioperative setting: Implications for patient care
    • Bose D, Meric-Bernstam F, Hofstetter W, Reardon DA, Flaherty KT, Ellis LM. Vascular endothelial growth factor targeted therapy in the perioperative setting: implications for patient care. Lancet Oncol. 2010;11(4):373-382.
    • (2010) Lancet Oncol , vol.11 , Issue.4 , pp. 373-382
    • Bose, D.1    Meric-Bernstam, F.2    Hofstetter, W.3    Reardon, D.A.4    Flaherty, K.T.5    Ellis, L.M.6
  • 21
    • 24644454338 scopus 로고    scopus 로고
    • Surgical resection after downsizing of colorectal liver metastasis in the era of bevacizumab
    • Ellis LM, Curley SA, Grothey A. Surgical resection after downsizing of colorectal liver metastasis in the era of bevacizumab. J Clinic Oncol. 2005;23:4853-4855.
    • (2005) J Clinic Oncol , vol.23 , pp. 4853-4855
    • Ellis, L.M.1    Curley, S.A.2    Grothey, A.3
  • 22
    • 77950340095 scopus 로고    scopus 로고
    • Serious wound healing complications (sWHC) following surgery in patients (pts) with metastatic colorectal cancer (mCRC) receiving bevacizumab (BV): Results from the BRiTE observational cohort study (OCS)
    • abstract 4105
    • Sugrue MM, Purdie DM, Feng S, et al. Serious wound healing complications (sWHC) following surgery in patients (pts) with metastatic colorectal cancer (mCRC) receiving bevacizumab (BV): results from the BRiTE observational cohort study (OCS). Proc Am Soc Clin Oncol. 2008;26(Suppl 15):abstract 4105.
    • (2008) Proc Am Soc Clin Oncol , vol.26 , Issue.SUPPL. 15
    • Sugrue, M.M.1    Purdie, D.M.2    Feng, S.3
  • 23
    • 79956218863 scopus 로고    scopus 로고
    • Ranibizumab and bevacizumab for neovascular age-related macular degeneration
    • For the CATT Research Group
    • Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL, Jaffe GJ; For the CATT Research Group. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011;364(20):1897-1908.
    • (2011) N Engl J Med , vol.364 , Issue.20 , pp. 1897-1908
    • Martin, D.F.1    Maguire, M.G.2    Ying, G.S.3    Grunwald, J.E.4    Fine, S.L.5    Jaffe, G.J.6
  • 25
    • 33846459028 scopus 로고    scopus 로고
    • Histologic characterization of vaginal vs abdominal surgical wound healing in a rabbit model
    • Abramov Y, Golden B, Sullivan M, et al. Histologic characterization of vaginal vs abdominal surgical wound healing in a rabbit model. Wound Repairs Regen. 2007;15(1):80-86.
    • (2007) Wound Repairs Regen , vol.15 , Issue.1 , pp. 80-86
    • Abramov, Y.1    Golden, B.2    Sullivan, M.3
  • 26
    • 48249153186 scopus 로고
    • Intraclass correlations: Uses in assessing rater reliability
    • Shrout PE, Fleiss JL. Intraclass correlations: Uses in assessing rater reliability. Psychol Bull. 1979;86:420-428.
    • (1979) Psychol Bull , vol.86 , pp. 420-428
    • Shrout, P.E.1    Fleiss, J.L.2
  • 29
    • 0023906952 scopus 로고
    • Fibrinogen influx and accumulation of cross-linked fibrin in healing wounds and in tumor stroma
    • Brown LF, Van De Water L, Harvery VS, Dvorak HF. Fibrinogen influx and accumulation of cross-linked fibrin in healing wounds and in tumor stroma. Am J Pathol. 1988;130:455-465.
    • (1988) Am J Pathol , vol.130 , pp. 455-465
    • Brown, L.F.1    van de Water, L.2    Harvery, V.S.3    Dvorak, H.F.4
  • 30
    • 0026515385 scopus 로고
    • Healing of partial thickness porcine skin wounds in a liquid environment
    • Breuing K, Eriksson E, Liv P, Miller DR. Healing of partial thickness porcine skin wounds in a liquid environment. J Surg Res. 1992;52:50.
    • (1992) J Surg Res , vol.52 , pp. 50
    • Breuing, K.1    Eriksson, E.2    Liv, P.3    Miller, D.R.4
  • 31
    • 0035746834 scopus 로고    scopus 로고
    • Antibody neutralization of vascular endothelial growth factor inhibits wound granulation tissue formation
    • Howdieshell TR, Callaway D, Webb WL, et al. Antibody neutralization of vascular endothelial growth factor inhibits wound granulation tissue formation. J Surg Res. 2001;96:173-182.
    • (2001) J Surg Res , vol.96 , pp. 173-182
    • Howdieshell, T.R.1    Callaway, D.2    Webb, W.L.3
  • 32
    • 33745782355 scopus 로고    scopus 로고
    • Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration
    • Rich RM, Rosenfeld PJ, Pulafito CA, et al. Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina. 2006;26:495-511.
    • (2006) Retina , vol.26 , pp. 495-511
    • Rich, R.M.1    Rosenfeld, P.J.2    Pulafito, C.A.3
  • 33
    • 20144372969 scopus 로고    scopus 로고
    • Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study
    • Michels S, Rosenfeld PJ, Puliafito CA, Marcus EN, Venkatraman AS. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study. Ophthalmology. 2005;112(6):1035-1047.
    • (2005) Ophthalmology , vol.112 , Issue.6 , pp. 1035-1047
    • Michels, S.1    Rosenfeld, P.J.2    Puliafito, C.A.3    Marcus, E.N.4    Venkatraman, A.S.5
  • 34
    • 70350575734 scopus 로고    scopus 로고
    • Safety implications of vascular endothelial growth factor blockade for subjects receiving intravitreal anti-vascular endothelial growth factor therapies
    • Csaky K, Do DV. Safety implications of vascular endothelial growth factor blockade for subjects receiving intravitreal anti-vascular endothelial growth factor therapies. Am J Ophthalmol. 2009;148(5): 647-656.
    • (2009) Am J Ophthalmol , vol.148 , Issue.5 , pp. 647-656
    • Csaky, K.1    Do, D.V.2
  • 35
    • 34247562266 scopus 로고    scopus 로고
    • Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration
    • VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group
    • Chakravarthy U, Adamis AP, Cunningham ET Jr, Goldbaum M, Guyer DR. VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group. Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration. Ophthalmology. 2006;113:1508-1521.
    • (2006) Ophthalmology , vol.113 , pp. 1508-1521
    • Chakravarthy, U.1    Adamis, A.P.2    Cunningham Jr., E.T.3    Goldbaum, M.4    Guyer, D.R.5
  • 36
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in-vivo role of platelet-derived growth factor
    • Heldin CH, Westermark B. Mechanism of action and in-vivo role of platelet-derived growth factor. Physiol Rev. 1999;79:1283-1316.
    • (1999) Physiol Rev , vol.79 , pp. 1283-1316
    • Heldin, C.H.1    Westermark, B.2
  • 37
    • 0035254648 scopus 로고    scopus 로고
    • Angiogenesis: Regulators and clinical applications
    • Liekens S, De Clercq E, Neyts J. Angiogenesis: Regulators and clinical applications. Biochem Pharmacol. 2001;61:253-270.
    • (2001) Biochem Pharmacol , vol.61 , pp. 253-270
    • Liekens, S.1    de Clercq, E.2    Neyts, J.3
  • 38
    • 0033517356 scopus 로고    scopus 로고
    • Cutaneous wound healing
    • Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738-746.
    • (1999) N Engl J Med , vol.341 , pp. 738-746
    • Singer, A.J.1    Clark, R.A.2
  • 39
    • 13944266313 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of ranibizumab after a single intravitreal administration
    • Gaudreault J, Fei D, Rusit J, Suboc P, Shiu V. Preclinical pharmacokinetics of ranibizumab after a single intravitreal administration. Invest Ophthalmol Vis Sci. 2005;46:726-733.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 726-733
    • Gaudreault, J.1    Fei, D.2    Rusit, J.3    Suboc, P.4    Shiu, V.5
  • 40
    • 77949887728 scopus 로고    scopus 로고
    • Pharmacokinetics of bevacizumab and its effect on vascular endothelial growth factor after intravitreal injection of bevacizumab in macaque eyes
    • Miyake T, Sawada O, Kakinoki M, et al. Pharmacokinetics of bevacizumab and its effect on vascular endothelial growth factor after intravitreal injection of bevacizumab in macaque eyes. Invest Ophthalmol Vis Sci. 2010;51:1606-1608.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 1606-1608
    • Miyake, T.1    Sawada, O.2    Kakinoki, M.3
  • 42
    • 84863051725 scopus 로고    scopus 로고
    • Macugen (pegaptanib sodium injection) product information. RX List. Available at, Accessed February 11
    • Macugen (pegaptanib sodium injection) product information. RX List. The Internet Drug List. Available at: http://www.rxlist.com/macugendrug.htm. Accessed February 11, 2009.
    • (2009) The Internet Drug List
  • 43
    • 0031848006 scopus 로고    scopus 로고
    • Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn
    • Grad S, Ertel W, Keel M, Infanger M, Vonderschmitt DJ, Maly FE. Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn. Clin Chem Lab Med. 1998;36(6): 379-383.
    • (1998) Clin Chem Lab Med , vol.36 , Issue.6 , pp. 379-383
    • Grad, S.1    Ertel, W.2    Keel, M.3    Infanger, M.4    Vonderschmitt, D.J.5    Maly, F.E.6
  • 44
    • 0036933570 scopus 로고    scopus 로고
    • Serum and plasma levels of FGF-2 and VEGF in healthy blood donors
    • Larsson A, Skoldenberg E, Ericson H. Serum and plasma levels of FGF-2 and VEGF in healthy blood donors. Angiogenesis. 2002;4: 107-110.
    • (2002) Angiogenesis , vol.4 , pp. 107-110
    • Larsson, A.1    Skoldenberg, E.2    Ericson, H.3
  • 45
    • 67650602069 scopus 로고    scopus 로고
    • Hypoxemic resuscitation after hemorrhagic shock is accompanied by reduced serum levels of angiopoietin-2
    • Douzinas E, Betrosian A, Livaditi O, et al. Hypoxemic resuscitation after hemorrhagic shock is accompanied by reduced serum levels of angiopoietin-2. Cytokine. 2009;47(2):82-84.
    • (2009) Cytokine , vol.47 , Issue.2 , pp. 82-84
    • Douzinas, E.1    Betrosian, A.2    Livaditi, O.3
  • 46
    • 0032962265 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics, interspecies scaling and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor
    • Lin YS, Nguyen C, Medoza JL, et al. Preclinical pharmacokinetics, interspecies scaling and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor. J Pharmacol Exp Ther. 1999;299:371-378.
    • (1999) J Pharmacol Exp Ther , vol.299 , pp. 371-378
    • Lin, Y.S.1    Nguyen, C.2    Medoza, J.L.3
  • 47
    • 0033005286 scopus 로고    scopus 로고
    • Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury
    • Watkins RH, D'Angio CT, Ryan RM, Patel A, Maniscalco WM. Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury. Am J Physiol. 1999;276(5 Pt 1):858-867.
    • (1999) Am J Physiol , vol.276 , Issue.5 PART 1 , pp. 858-867
    • Watkins, R.H.1    D'angio, C.T.2    Ryan, R.M.3    Patel, A.4    Maniscalco, W.M.5


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