Robust optimization of intensity modulated proton therapy

Medical Physics

Volumn 39, Issue 2, 2012, Pages 1079-1091

  Liu, Wei ^a   Zhang, Xiaodong ^a   Li, Yupeng ^a   Mohan, Radhe ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

IMPT; robust optimization

Indexed keywords

INVERSE PROBLEMS; ITERATIVE METHODS; PROTON BEAM THERAPY; PROTON BEAMS; TISSUE;

CLINICAL TARGET VOLUMES; IMPT; INTENSITY MODULATED PROTON THERAPIES; OBJECTIVE FUNCTION VALUES; PLANNING TARGET VOLUMES; ROBUST OPTIMIZATION; ROBUST OPTIMIZATION METHOD; TRADITIONAL PLANNING;

OPTIMIZATION;

PERU TOMATO MOSAIC VIRUS;

EID: 84863062792     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3679340     Document Type: Article

References (24)

1. S. P. Register, X. Zhang, R. Mohan, and J. Y. Chang, Proton stereotactic body radiation therapy for clinically challenging cases of centrally and superiorly located stage I non-small-cell lung cancer., Int. J. Radiat. Oncol., Biol., Phys. 80, 1015-1022 (2010). 10.1016/j.ijrobp.2010.03.012
2. X. D. Zhang, Y. P. Li, X. N. Pan, X. Q. Li, R. Mohan, R. Komaki, J. D. Cox, and J. Y. Chang, Intensity-modulated proton therapy reduces the dose to normal tissue compared with intensity-modulated radiation therapy or passive scattering proton therapy and enables individualized radical raditherapy for extensive stage IIIB non-small-cell lung cancer: A virtual clinical study., Int. J. Radiat. Oncol., Biol., Phys. 77, 357-366 (2010). 10.1016/j.ijrobp.2009.04. 028
3. A. Lomax, Intensity modulation methods for proton radiotherapy., Phys. Med. Biol. 44, 185 (1999). 10.1088/0031-9155/44/1/014
4. A. J. Lomax, Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: the potential effects of calculational uncertainties., Phys. Med. Biol. 53, 1027-1042 (2008). 10.1088/0031-9155/53/4/ 014
5. A. J. Lomax, Intensity modulated proton therapy and its sensitivity to treatment uncertainties 2: the potential effects of inter-fraction and inter-field motions., Phys. Med. Biol. 53, 1043-1056 (2008). 10.1088/0031-9155/53/4/015
6. A. J. Lomax, T. Boehringer, A. Coray, E. Egger, G. Goitein, M. Grossmann, P. Juelke, S. Lin, E. Pedroni, B. Rohrer, W. Roser, B. Rossi, B. Siegenthaler, O. Stadelmann, H. Stauble, C. Vetter, and L. Wisser, Intensity modulated proton therapy: A clinical example., Med. Phys. 28, 317-324 (2001). 10.1118/1.1350587
7. D. Pflugfelder, J. J. Wilkens, and U. Oelfke, Worst case optimization: a method to account for uncertainties in the optimization of intensity modulated proton therapy., Phys. Med. Biol. 53, 1689-1700 (2008). 10.1088/0031-9155/53/6/ 013
8. J. Unkelbach, T. Bortfeld, B. C. Martin, and M. Soukup, Reducing the sensitivity of IMPT treatment plans to setup errors and range uncertainties via probabilistic treatment planning., Med. Phys. 36, 149-163 (2009). 10.1118/1.3021139
9. J. Unkelbach, T. C. Y. Chan, and T. Bortfeld, Accounting for range uncertainties in the optimization of intensity modulated proton therapy., Phys. Med. Biol. 52, 2755-2773 (2007). 10.1088/0031-9155/52/10/009
10. J. Unkelbach, M. Soukup, M. Alber, and T. Bortfeld, Range setup and dose calculation errors in IMPT and their interrelation., World Congress on Medical Physics and Biomedical Engineering, Vol. 25, pp. 900-903 (2009).
11. Y. X. Kang, X. D. Zhang, J. Y. Chang, H. Wang, X. Wei, Z. X. Liao, R. Komaki, J. D. Cox, P. A. Balter, H. Liu, X. R. Zhu, R. Mohan, and L. Dong, 4D proton treatment planning strategy for mobile lung tumors., Int. J. Radiat. Oncol., Biol., Phys. 67, 906-914 (2007). 10.1016/j.ijrobp.2006.10.045
12. D. Maleike, J. Unkelbach, and U. Oelfke, Simulation and visualization of dose uncertainties due to interfractional organ motion., Phys. Med. Biol. 51, 2237-2252 (2006). 10.1088/0031-9155/51/9/009
13. X. D. Zhang, Y. P. Li, X. N. Pan, X. Q. Li, R. Mohan, R. Komaki, J. D. Cox, and J. Y. Chang, Intensity-modulated proton therapy reduces the dose to normal tissue compared with intensity-modulated radiation therapy or passive scattering proton therapy and enables individualized radical radiotherapy for extensive stage IIIB non-small-cell lung cancer: a virtual clinical study., Int. J. Radiat. Oncol., Biol., Phys. 77, 357-366 (2010). 10.1016/j.ijrobp.2009.04. 028
14. S. B. Jiang, C. Pope, K. M. Al Jarrah, J. H. Kung, and T. Bortfeld, An experimental investigation on intra-fractional organ motion effects in lung IMRT treatments., Phys. Med. Biol. 48, 1773-1784 (2003). 10.1088/0031-9155/48/12/307
15. J. Meyer, J. Bluett, R. Amos, L. Levy, S. Choi, Q. N. Nguyen, X. R. Zhu, M. Gillin, and A. Lee, Spot scanning proton beam therapy for prostate cancer: Treatment planning technique and analysis of consequences of rotational and translational alignment errors., Int. J. Radiat. Oncol., Biol., Phys. 78, 428-434 (2010). 10.1016/j.ijrobp.2009.07.1696
16. A. Fredriksson, A. Forsgren, and B. Hardemark, Minimax optimization for handling range and setup uncertainties in proton therapy., Med. Phys. 38, 1672-1684 (2011). 10.1118/1.3556559
17. U. Oelfke and T. Bortfeld, Inverse planning for photon and proton beams., Med. Dosim. 26, 113-124 (2001). 10.1016/S0958-3947(01)00057-7
18. Q. W. Wu and R. Mohan, Algorithms and functionality of an intensity modulated radiotherapy optimization system., Med. Phys. 27, 701-711 (2000). 10.1118/1.598932
19. X. D. Zhang, H. Liu, X. C. Wang, L. Dong, Q. W. Wu, and R. Mohan, Speed and convergence properties of gradient algorithms for optimization of IMRT., Med. Phys. 31, 1141-1152 (2004). 10.1118/1.1688214
20. Y. Li, X. Zhang, and R. Mohan, A hybrid inverse planning algorithm of IMPT optimization., Med. Phys. 35, 2867 (2008). 10.1118/1.2962355
21. Y. P. Li, X. D. Zhang, and R. Mohan, An efficient dose calculation strategy for intensity modulated proton therapy., Phys. Med. Biol. 56, N71-N84 (2011). 10.1088/0031-9155/56/4/N03
22. F. Albertini, E. B. Hug, and L. A. J., Is it necessary to plan with safety margins for actively scanned proton therapy?, Phys. Med. Biol. 56, 4399-4413 (2011). 10.1088/0031-9155/56/14/011
23. A. J. Lomax, E. Pedroni, H. Rutz, and G. Goitein, The clinical potential of intensity modulated proton therapy., Z. Med. Phys. 14, 147-152 (2004).
24. A. Trofimov, J. Kang, J. Unkelbach, J. A. Adams, X. Zhang, T. Bortfeld, N. J. Liebsch, and T. F. DeLaney, Evaluation of dosimetric gain and uncertainties in proton therapy delivery with scanned pencil beam in treatment of base-of-skull and spinal tumors., Int. J. Radiat. Oncol., Biol., Phys. 78, S133-S134 (2010). 10.1016/j.ijrobp.2010.07.334